d-amphetamine stimulates unconditioned exploration/approach behaviors in crayfish: Towards a conserved evolutionary function of ancestral drug reward

Alcaro, Antonio; Panksepp, Jaak; Huber, Robert

doi:10.1016/j.pbb.2011.04.004

Cited by 28 publications

(20 citation statements)

References 55 publications

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“…its evolutionarily conserved effects on locomotor behavior, learning and memory, aggression, and decision making (Paulus and Geyer, 1997;Liden et al, 2010;Alcaro et al, 2011;Luchiari et al, 2015). Lastly, crayfish have been shown to exhibit behavioral manifestations such as drug seeking, withdrawal, and tolerance related to other substances of abuse , and thus additional neurobehavioral experiments that extend beyond the acute effects of alcohol exposure seem feasible.…”

Section: Discussionmentioning

confidence: 99%

Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish

Swierzbinski

Lazarchik

Herberholz

2017

Journal of Experimental Biology

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The effects of alcohol on society can be devastating, both as an immediate consequence of acute intoxication and as a powerful drug of abuse. However, the neurocellular mechanisms of alcohol intoxication are still elusive, partly because of the complex interactions between alcohol and nervous system function. We found that juvenile crayfish are behaviorally sensitive to acute alcohol exposure and progress through stages that are strikingly similar to those of most other intoxicated organisms. Most surprisingly, we found that the social history of the animals significantly modified the acute effects of alcohol. Crayfish taken from a rich social environment became intoxicated more rapidly than animals that were socially isolated before alcohol exposure. In addition, we found that the modulation of intoxicated behaviors by prior social experience was paralleled on the level of individual neurons. These results significantly improve our understanding of the mechanisms underlying the interplay between social experience, alcohol intoxication and nervous system function.

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Section: Discussionmentioning

confidence: 99%

Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish

Swierzbinski

Lazarchik

Herberholz

2017

Journal of Experimental Biology

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“…This injection point was determined according to Alcaro et al . (). After drug injection, animals were re‐isolated separately in the stocked containers.…”

Section: Methodsmentioning

confidence: 97%

Role of cAMP signalling in winner and loser effects in crayfish agonistic encounters

Momohara

Minami

Kanai

et al. 2016

Eur J of Neuroscience

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For territorial animals, establishment of status-dependent dominance order is essential to maintain social stability. In agonistic encounters of the crayfish Procambarus clarkii, a difference of body length of 3-7% is enough for larger animals to become dominant. Despite a physical disadvantage, small winners of the first pairings were more likely to win subsequent conflicts with larger inexperienced animals. In contrast, the losers of the first pairings rarely won subsequent conflicts with smaller naive animals. Such experiences of previous winning or losing affected agonistic outcomes for a long period. The winner effects lasted more than 2 weeks and the loser effect lasted about 10 days. Injection of 5HT1 receptor antagonist into the dominant animals 15-30 min after establishment of dominance order blocked the formation of the winner effects. In contrast, injection of adrenergic-like octopamine receptor antagonist into subordinate animals blocked the formation of the loser. 5HT1 receptors are negatively coupled to adenylyl cyclase and adrenergic-like octopamine receptors are positively coupled. Consistent with this, dominant animals failed to show the winner effect when injected with pCPT-cAMP, a cAMP analogue, and subordinate animals failed to show a loser effect when injected with adenylyl cyclase inhibitor SQ 22536. These results suggest that an increase and decrease of cAMP concentration is essential in mediating loser and winner effects, respectively. Furthermore, formation of the loser effect was blocked by injection of protein kinase A (PKA) inhibitor H89, suggesting long-term memory of the loser effect is dependent on the cAMP-PKA signalling pathway.

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“…Injection of drugs ( = 1 ml in volume) was made into the pericardial sinus from the dorsal carapace within the caudal third of the pericard to avoid damaging the underlying heart through a 27-3/4 gauge needle. This injection point was determined according to [41]. The amount of injected drugs was 10 nmol if a crayfish was injected with 1 ml of 10 µM drug solution.…”

Section: Methodsmentioning

confidence: 99%

Aminergic Control of Social Status in Crayfish Agonistic Encounters

2013

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Using pairings of male crayfish Procambarus clarkii with a 3–7% difference in size, we confirmed that physically larger crayfish were more likely to win encounters (winning probability of over 80%). Despite a physical disadvantage, small winners of the first pairings were more likely to win their subsequent conflicts with larger naive animals (winning probability was about 70%). By contrast, the losers of the first pairings rarely won their subsequent conflicts with smaller naive animals (winning probability of 6%). These winner and loser effects were mimicked by injection of serotonin and octopamine. Serotonin-injected naive small crayfish were more likely to win in pairings with untreated larger naive crayfish (winning probability of over 60%), while octopamine-injected naive large animals were beaten by untreated smaller naive animals (winning probability of 20%). Furthermore, the winner effects of dominant crayfish were cancelled by the injection of mianserin, an antagonist of serotonin receptors and were reinforced by the injection of fluoxetin, serotonin reuptake inhibitor, just after the establishment of social order of the first pairings. Injection of octopamine channel blockers, phentolamine and epinastine, by contrast, cancelled the loser effects. These results strongly suggested that serotonin and octopamine were responsible for winner and loser effects, respectively.

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d-amphetamine stimulates unconditioned exploration/approach behaviors in crayfish: Towards a conserved evolutionary function of ancestral drug reward

Cited by 28 publications

References 55 publications

Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish

Prior social experience affects the behavioral and neural responses to acute alcohol in juvenile crayfish

Role of cAMP signalling in winner and loser effects in crayfish agonistic encounters

Aminergic Control of Social Status in Crayfish Agonistic Encounters

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