D-Amino Acid Aberrations in Cerebrospinal Fluid and Plasma of Smokers

Luykx, Jurjen J.; Bakker, Steven C.; Boxmeer, Loes van; Vinkers, Christiaan H.; Smeenk, Hanne E.; Visser, W. J.; Verhoeven‐Duif, Nanda M.; Strengman, Eric; Buizer-Voskamp, Jacobine E.; Groene, Lizzy de; Dongen, Eric P.A. van; Borgdorff, Paul; Bruins, Peter; Koning, Tom J. de; Kahn, René S.; Ophoff, Roel A.

doi:10.1038/npp.2013.103

Cited by 19 publications

(10 citation statements)

References 48 publications

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“…The first participant was recruited before July 2008, and plasma and CSF were collected preceding the administration of spinal anesthesia for minor elective surgery at different hospitals in and near Utrecht, Netherlands, between July 2008 and November 2011. Subject characteristics and details of sample collection were described previously (38)(39)(40). In summary, subjects were included if they were of North-Western European descent (ie, all grandparents born in the Netherlands, Belgium, France, Germany, Denmark, or the United Kingdom).…”

Section: Subjects and Sample Collectionmentioning

confidence: 99%

Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

Albersen¹,

Bosma²,

Luykx³

et al. 2014

The American Journal of Clinical Nutrition

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Section: Subjects and Sample Collectionmentioning

confidence: 99%

Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

Albersen¹,

Bosma²,

Luykx³

et al. 2014

The American Journal of Clinical Nutrition

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“…In humans, AAs most commonly occur in their l‐ form, but there is increasing evidence that d‐ AAs also play essential roles in human biology. d‐ AAs are involved in the pathogenesis of psychiatric disease and abnormal levels were found in human disorders, such as schizophrenia and Alzheimer's disease . In the aforementioned applications, the AA enantiomers often are minor components of complex mixtures, such as biological fluids and food, requiring the use of highly selective separation and detection techniques for their unambiguous assessment.…”

Section: Introductionmentioning

confidence: 99%

Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis–mass spectrometry

et al. 2016

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d-Amino acids (AAs) are increasingly being recognized as essential molecules in biological systems. Enantioselective analysis of proteinogenic AAs in biological samples was accomplished by CE-MS employing β-CD as chiral selector and ESI via sheath-liquid (SL) interfacing. Prior to analysis, AAs were fully derivatized with FMOC, improving AA-enantiomer separation and ESI efficiency. In order to optimize the separation and MS detection of FMOC-AAs, the effects of type and concentration of CD in the BGE, the composition of the SL, and MS-interfacing parameters were evaluated. Using a BGE of 10 mM β-CD in 50 mM ammonium bicarbonate (pH 8) containing 15% v/v isopropanol, a SL of isopropanol-water-1 M ammonium bicarbonate (50:50:1, v/v/v) at a flow rate of 3 μL/min, and a nebulizer gas pressure of 2 psi, 15 proteinogenic AAs could be detected with enantioresolutions up to 3.5 and detection limits down to 0.9 μM (equivalent to less than 3 pg AA injected). The selectivity of the method was demonstrated by the analysis of spiked cerebrospinal fluid, allowing specific detection of d-AAs. Repeatability and linearity obtained for cerebrospinal fluid were similar to standard solutions, with peak area and migration-time RSDs (n = 5) below 16.2 and 1.6%, respectively, and a linear response (R(2) ≥ 0.977) in the 3-90 μM range.

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“…Smoking is often more common in patients groups than among HC (e.g. Jakobsson et al (33)) and smoking status has previously been associated with CSF biomarker levels of amino acids in CSF (51). However, Pålsson et al found that adding smoking as a co-variate did not explain observed differences between BD and HC for glutamate markers (41).…”

Section: ) Smokingmentioning

confidence: 99%

Biomarkers in cerebrospinal fluid of patients with bipolar disorder versus healthy individuals: A systematic review

Knorr

Simonsen

Zetterberg

et al. 2019

European Neuropsychopharmacology

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Background: The pathophysiological processes of bipolar disorder (BD) may be detectable by the use of cerebrospinal fluid (CSF) biomarkers. Biomarkers for BD may in time assist with diagnosis, prediction of disease course, or identification of response outcome to treatments. Explorative biomarkers have been proposed in many studies but no CSF biomarkers are integrated into routine clinical practice.Aim: We aimed for the first time to review studies of CSF biomarkers in patients with BD compared to healthy control individuals (HC). We investigated the effect of diagnosis, age, gender, clinical state, medication, technical characteristics of tests, fasting state and, cognitive function if applicable.Method: We did a systematic review according to the PRISMA Statement based on comprehensive database searches for studies on cerebrospinal biomarkers in patients with bipolar disorder versus HC. Risk of bias was systematically assessed.Results: The search strategy identified X studies of which thirty-four fulfilled the inclusion criteria.A total of 117 unique biomarkers were investigated. Forty biomarkers showed statistically significant differences between BD and HC. Eleven biomarkers were evaluated in more than one study. Only the findings of elevated homovanillic acid and 5-hydroxy-indoleacetic acid were replicated across studies. Most studies had a cross sectional design and were influenced by risk of bias mainly due to small sample size, lack of data on mood state at the time of the CSF puncture and not considering potential confounders including age, gender, diagnoses, BMI, life style factors such as smoking, and psychotropic medication.Conclusion: Specific monoamine CSF biomarkers may be related to the pathophysiology of BD.Future studies must aim at increasing the level of evidence by validating the positive findings in prospective studies with stringent methodology. limits; English language and human, using the following search terms both as keywords and as text words: Cerebrospinal fluid AND bipolar disorder. In addition reference lists of relevant studies were searched by hand. Study selection and data collection processStudy titles and abstracts identified by the initial search were screened by UK. Subsequent retrieval of full text articles or other additional information, assessment for eligibility and data extraction was performed independently by two researchers; UK and AHS. Disagreements were resolved by discussion with LVK.The association between cognitive function in BD and various CSF markers has been sporadically investigated (4-7), but these data were not included in this review. Data itemsA data sheet was constructed and the following data was extracted: Study identification, age, gender, duration of illness, BD subtype, symptom severity, duration of current affective state, medication use, smoking, alcohol use, BMI, exercise or physical activity, biomarker concentration in CSF, measurement method, blinding of analysts, time of day and fasting state at lumbar puncture.In comparisons between BD pati...

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D-Amino Acid Aberrations in Cerebrospinal Fluid and Plasma of Smokers

Cited by 19 publications

References 48 publications

Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

Vitamin B-6 vitamers in human plasma and cerebrospinal fluid

Enantioselective analysis of proteinogenic amino acids in cerebrospinal fluid by capillary electrophoresis–mass spectrometry

Biomarkers in cerebrospinal fluid of patients with bipolar disorder versus healthy individuals: A systematic review

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