Częstość zakażeń i kolonizacji Klebsiella pneumoniae izolowanych od chorych leczonych na oddziale anestezjologii i intensywnej terapii

Sękowska, Alicja; Gospodarek, Eugenia; Kusza, Krzysztof

doi:10.5603/ait.2014.0045

Cited by 12 publications

(5 citation statements)

References 14 publications

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“…The rapidly increasing number of ESBL-producing K. pneumoniae isolates, particularly in high-risk wards such as ICUs, and the continuous influx of strains from hospital settings to the community can lead to serious problems in clinical settings and public health (1, 2). More than half of our strains from ICU patients (56.5%) were ESBL-producers, which is in agreement with other reports (23,24).…”

Section: Discussionsupporting

confidence: 93%

Prevalence of Extended-Spectrum β-Lactamases Among Klebsiella pneumoniae Isolated from Intensive Care Unit Patients in a Tertiary Hospital

Peerayeh

Derakhshan

Fallah

et al. 2019

Arch Clin Infect Dis

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Background: The increased prevalence of extended-spectrum β-lactamases (ESBLs)-producing virulent strains possibly leads to serious outbreaks in hospitals. Objectives: The aims of the study were to detect ESBLs in Klebsiella pneumoniae isolated from patients in intensive care units (ICUs) of a hospital and to investigate their genetic relationships. Methods: A total number of 85 K. pneumoniae isolates were detected in the specimens of ICU patients in a tertiary hospital in the southwest of Tehran, Iran. Antibiotic susceptibility was determined by the disk diffusion method. The rmpA and wcaG virulence genes were detected by polymerase chain reaction (PCR). The ESBL-positive isolates were typed using multilocus variable-number tandem repeat analysis (MLVA) method. Results: Of the 85 K. pneumoniae isolates, 48 (56.5%) produced ESBLs. There were statistically significant differences in the prevalence of virulence genes based on ESBL production. The typing of the 48 ESBL-positive isolates showed a significant genetic relatedness with the identification of nine MLVA types. Conclusions: This study showed a relatively high prevalence of ESBL in K. pneumoniae isolated from ICU patients and a low diversity between these isolates. The selection of ESBL-producing clones was mainly responsible for the spread of K. pneumoniae in the ICUs.

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Section: Discussionsupporting

confidence: 93%

Prevalence of Extended-Spectrum β-Lactamases Among Klebsiella pneumoniae Isolated from Intensive Care Unit Patients in a Tertiary Hospital

Peerayeh

Derakhshan

Fallah

et al. 2019

Arch Clin Infect Dis

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“…These bacteria are important aetiological agent of nosocomial infections, particularly in intensive care units patients, paediatric patients and patients after transplantation. The most frequent infections includes: pneumonia, urinary tract infections, surgical wound infections, soft tissue infections and blood infections (Hansen et al ; Sękowska et al ; Pitout et al ; Navon‐Venezia et al ). In hospitalized patients an important factor contributing to the development of infection is an initial colonization of the food tract (Sękowska et al ).…”

Section: Introductionmentioning

confidence: 99%

Elimination of Klebsiella pneumoniae NDM from the air and selected surfaces in hospital using radiant catalytic ionization

Skowron

Wiktorczyk

Kwiecińska-Piróg

et al. 2019

Lett Appl Microbiol

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Significance and Impact of the Study: Microbial contamination of air and surfaces in hospitals play an important role in healthcare-associated infections. The aim was the assessment of Klebsiella pneumoniae elimination using radiant catalytic ionization (RCI). K. pneumoniae are aetiological agent of nosocomial infections, such as: pneumonia, infections of urinary tract, blood, e.t.c. The strains producing the New Delhi metallo-b-lactamases are one of the greatest epidemiological threat. The use of RCI eliminate the tested bacteria from the hospital environment, but can also be effective in food processing plants or public facilities, ensuring the safety of people and products. This research is scarce in references and has a large innovation and application potential. AbstractDue to increasing antibiotic resistance Klebsiella pneumoniae is a serious threat for the hospitalized patients. The aim of this study was the assessment of radiant catalytic ionization (RCI) efficacy on K. pneumoniae reduction in the air and on selected surfaces. Four K. pneumoniae NDM and ESBLs-producing strains were included in the study. Three types of surface were tested: cottonpolyester, terry and PVC. It was found that RCI significantly reduced the number of bacteria from all types of surface (terry: 0Á56-1Á22 log CFU m 2 , cotton-polyester: 2Á15-3Á71 log CFU per m 2 , PVC: 4Á45-4Á92 log CFU per m 2 ) as well as from the air (1Á80 log CFU per m 3 ). The RCI technology may be a useful disinfection method in hospitals.

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“…The selection of the Intensive Care Unit (ICU), General Surgery Department (GSD), and Nutrition and Metabolic Diseases Department (NMDD) was due to the following criteria: the ICU is the epicentre for the dissemination of MDR strains; surgery combines multiple extrinsic factors which create large breaches in the natural defence systems of the organism, and metabolic pathology is acknowledged to have an intrinsic potential for the increased receptivity to infections. Colonisation strains were not excluded, because colonisation may cause infections, especially in patients with suppressed immune systems or in invasive procedures such as catheters or surgeries [7]. On the other hand, there is also the possibility for the transmission of MDR strains from colonised patients to other people (patients and medical staff) by direct or indirect contact [8].…”

Section: Introductionmentioning

confidence: 99%

Multidrug-Resistant Gram-Negative Bacilli: A Retrospective Study of Trends in a Tertiary Healthcare Unit

et al. 2018

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Background and objective: Bacterial multidrug resistance is particularly common in Gram-negative bacilli (GNB), with important clinical consequences regarding their spread and treatment options. The aim of this study was to investigate the trend of multidrug-resistant GNB (MDR-GNB) in high-risk hospital departments, between 2000–2015, in intervals of five years, with the intention of improving antibiotic therapy policies and optimising preventive and control practices. Materials and methods: This is an observational, retrospective study performed in three departments of the most important tertiary healthcare unit in the southwestern part of Romania: the Intensive Care Unit (ICU), the General Surgery Department (GSD), and the Nutrition and Metabolic Diseases Department (NMDD). MDR was defined as acquired resistance to at least one agent in three or more antimicrobial categories. Trends over time were determined by the Cochran–Armitage trend test and linear regression. Results: During the study period, a total of 2531 strains of MDR-GNB were isolated in 1999 patients: 9.20% in 2000, 18.61% in 2005, 37.02% in 2010, and 35.17% in 2015. The most significant increasing trend was recorded in the ICU (gradient = 7.63, R² = 0.842, p < 0.001). The most common MDR-GNB in the ICU was isolated from bronchoalveolar aspiration samples. Concerning the proportion of different species, most of the changes were recorded in the ICU, where a statistically significant increasing trend was observed for Proteus mirabilis (gradient = 2.62, R2 = 0.558, p < 0.001) and Acinetobacter baumannii (gradient = 2.25, R2 = 0.491, p < 0.001). Analysis of the incidence of the main resistance phenotypes proportion identified a statistically significant increase in carbapenem resistance in the ICU (Gradient = 8.27, R² = 0.866, p < 0.001), and an increased proportion of aminoglycoside-resistant strains in all three departments, but more importantly in the ICU and GSD. Conclusion: A statistically significant increasing trend was observed in all three departments; the most significant one was recorded in the ICU, where after 2010, carbapenem-resistant strains were isolated.

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Częstość zakażeń i kolonizacji Klebsiella pneumoniae izolowanych od chorych leczonych na oddziale anestezjologii i intensywnej terapii

Cited by 12 publications

References 14 publications

Prevalence of Extended-Spectrum β-Lactamases Among Klebsiella pneumoniae Isolated from Intensive Care Unit Patients in a Tertiary Hospital

Prevalence of Extended-Spectrum β-Lactamases Among Klebsiella pneumoniae Isolated from Intensive Care Unit Patients in a Tertiary Hospital

Elimination of Klebsiella pneumoniae NDM from the air and selected surfaces in hospital using radiant catalytic ionization

Multidrug-Resistant Gram-Negative Bacilli: A Retrospective Study of Trends in a Tertiary Healthcare Unit

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