Czech studies of lung cancer risk from radon

Tomášek, Ladislav; Placek, V.; Müller, T.; Heribanová, A; Matzner, Jan; Burian, I.; Holecek, J.

doi:10.1504/ijlr.2003.003486

Cited by 9 publications

(6 citation statements)

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“…In numerous studies on the influence of radon inhalation on lung cancer in humans (Table 1) and in pooled studies (Darby et al 2004;Lubin and Boice 1997;Lubin et al 2004;Tomášek et al 2003;Pavia et al 2003), the untested assumption that lung cancer incidence risk cannot be less than 1 has been applied. Therefore as a reference point in these studies, the risk ratio of 1 (or 100%) is usually used for low doses, which raises all the risk for higher doses greater than 1.…”

Section: Discussionmentioning

confidence: 99%

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Pooled Bayesian Analysis of Twenty-Eight Studies on Radon Induced Lung Cancers

Fornalski

Dobrzyński²

2011

Health Physics

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The influence of ionizing radiation of (222)Rn and its progeny on lung cancer risks that were published in 28 papers was re-analyzed using seven alternative dose-response models. The risks of incidence and mortality were studied in two ranges of low annual radiation dose: 0-70 mSv per year (391 Bq m(-3)) and 0-150 mSv per year (838 Bq m(-3)). Assumption-free Bayesian statistical methods were used. The analytical results demonstrate that the published incidence and mortality data do not show that radiation dose is associated with increased risk in this range of doses. This conclusion is based on the observation that the model assuming no dependence of the lung cancer induction on the radiation doses is at least ∼90 times more likely to be true than the other models tested, including the linear no-threshold (LNT) model.

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Section: Discussionmentioning

confidence: 99%

“…One should note, however, that some of these studies were reanalyzed earlier. The papers containing such pooled-type analysis are listed in Table 1 (Darby et al 2004;Lubin and Boice 1997;Lubin et al 2004;Tomášek et al 2003;Pavia et al 2003).…”

Section: Introductionmentioning

confidence: 99%

Pooled Bayesian Analysis of Twenty-Eight Studies on Radon Induced Lung Cancers

Fornalski

Dobrzyński²

2011

Health Physics

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“…Such an analysis would be possible with better statistical power, as in a joint uranium miner cohort pooling European uranium miners from German (42), Czech (43) and French (5) cohorts. Such an analysis would be possible with better statistical power, as in a joint uranium miner cohort pooling European uranium miners from German (42), Czech (43) and French (5) cohorts.…”

Section: Lung Dosesmentioning

confidence: 99%

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Leuraud¹,

et al. 2011

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A combined analysis of three case-control studies nested in three European uranium miner cohorts was performed to study the joint effects of radon exposure and smoking on lung cancer death risk. Occupational history and exposure data were available from the cohorts. Smoking information was reconstructed using self-administered questionnaires and occupational medical archives. Linear excess relative risk models adjusted for smoking were used to estimate the lung cancer risk associated with radon exposure. The study includes 1046 lung cancer cases and 2492 controls with detailed radon exposure data and smoking status. The ERR/WLM adjusted for smoking is equal to 0.008 (95% CI: 0.004-0.014). Time since exposure is shown to be a major modifier of the relationship between radon exposure and lung cancer risk. Fitting geometric mixture models yielded arguments in favor of a sub-multiplicative interaction between radon and smoking. This combined study is the largest case-control study to investigate the joint effects of radon and smoking on lung cancer risk among miners. The results confirm that the lung carcinogenic effect of radon persists even when smoking is adjusted for, with arguments in favor of a sub-multiplicative interaction between radon and smoking.

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“…Furthermore, ERR/WLM was modified by either duration of exposure or concentration. Since that study, new analyses of the North American and the Chinese cohorts have been published Stram et al, 1999;Hauptmann et al, 2001;Hornung, 2001;Duport, 2002;Archer et al, 2004;Kreisheimer, 2006), yet further follow-up was only conducted for the Czech (Tomásek, 2002;Tomásek and Zarska, 2004) and the French cohort (Rogel et al, 2002;Laurier et al, 2004). Although the evidence of a radon-related lung cancer risk among miners is large, it is based upon various heterogeneous cohorts for which the cohort-specific risk estimates vary by more than an order of magnitude.…”

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confidence: 99%

Lung cancer risk among German male uranium miners: a cohort study, 1946–1998

et al. 2006

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From 1946 to 1990 extensive uranium mining was conducted in the southern parts of the former German Democratic Republic. The overall workforce included several 100 000 individuals. A cohort of 59 001 former male employees of the Wismut Company was established, forming a large retrospective uranium miners' cohort for the time period 1946 -1998. Mean duration of follow-up was 30.5 years with a total of 1 801 630 person-years. Loss to follow-up was low at 5.3%. Of the workers, 16 598 (28.1%) died during the study period. Based on 2388 lung cancer deaths, the radon-related lung cancer risk is evaluated. The excess relative risk (ERR) per working level month (WLM) was estimated as 0.21% (95% CI: 0.18 -0.24). It was dependent on time since exposure and on attained age. The highest ERR/WLM was observed 15 -24 years after exposure and in the youngest age group (o55 years of age). While a strong inverse exposure-rate effect was detected for high exposures, no significant association was detected at exposures below 100 WLM. Excess relative risk /WLM was not modified by duration of exposure. The results would indicate the need to re-estimate the effects of risk modifying factors in current risk models as duration of exposure did not modify the ERR/WLM and there was only a modest decline of ERR/WLM with increasing time since exposure.

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Czech studies of lung cancer risk from radon

Cited by 9 publications

References 0 publications

Pooled Bayesian Analysis of Twenty-Eight Studies on Radon Induced Lung Cancers

Pooled Bayesian Analysis of Twenty-Eight Studies on Radon Induced Lung Cancers

Radon, Smoking and Lung Cancer Risk: Results of a Joint Analysis of Three European Case-Control Studies Among Uranium Miners

Lung cancer risk among German male uranium miners: a cohort study, 1946–1998

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