Cytrellis: A Novel Microcoring Technology for Scarless Skin Removal: Summary of Three Prospective Clinical Trials

Abstract

Background: We introduce an innovative and novel technology that achieves scarless skin removal without the use of thermal energy. Microcoring technology (MCT) uses a modified, hollow hypodermic needle to remove skin safely and without a scar. This method is advantageous compared to other fractional devices, given that it has the same benefits as energy-based devices (removal of skin cores without a scar), with the added value of immediate closure along the relaxed skin tension lines, with significantly less thermal energy. Methods: Three prospective clinical safety trials analyzing MCT treatment on abdominal and facial skin (short- and long-term) are described. Results: MCT treatment of human skin resulted in scarless skin removal that was well tolerated by patients. Healing occurred rapidly, with limited side effects. Skin area reduction (skin tightening) and increase in skin thickness were observed long term. Conclusions: MCT treatment of human skin is safe and well tolerated. Although further studies on efficacy are required to evaluate the full potential of MCT in skin rejuvenation, early findings such as skin tightening and increase in skin thickness are encouraging.

Safety and efficacy of a novel robotic, fractional micro-coring device in a swine model

“…The study comprised of four female domestic (sus scrofa domesticus) Large White pigs, approximately 4 months of age, each marked with 14 designated sites on their abdomen (~3x4 cm 2 per site). Twelve (12) sites were treated using Aime TM , at 6 different time points: days 0, 14, 21, 25, 27 and 28. At each time point, 2 sites were treated (for a total of 12 treated sites, in each pig, by day 28) (Table 1 and Supp Figure 2).…”

“…However, their use can result in side effects that include burns, hyper-or hypopigmentation, erosions, scarring, purpura and vascular necrosis 8,9 . In addition, there is lack of data on the ability of fractional lasers and radiofrequency devices to achieve skin tightening [10][11][12] . Another widely-used technique is microneedles, that present an excellent safety profile and quick recovery.…”

“…Another widely-used technique is microneedles, that present an excellent safety profile and quick recovery. However, since this technique does not result in tissue removal, significant skin tightening is difficult to achieve 12,13 .…”

“…The micro-coring technology (MCT) is a newly developed technology, designed to remove small skin columns using hollow hypodermic needles, without scar formation and without thermal energy. Although MCT is a highly promising technique, there are very limited data, from two preclinical studies and one clinical trial, on its safety and effectiveness 12,14,15 . Therefore, we have performed a pre-clinical study using a swine model to assess the safety and efficacy of a new robotic, fractional micro-coring device, Aime TM (Venus Concept Ltd., Tel Aviv, Israel), designed for skin tissue excision and resurfacing.…”

Dermal Micro-coring for the Treatment of Moderate to Severe Facial Wrinkles

“…2021;9:e3905. 7 This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.…”