Cytotrophoblast Expression of Integrin Extracellular Matrix Receptors Is Altered in Preeclampsia

Zhou, Yan; Damsky, Caroline H.; Chiu, King; Roberts, James M.; Fisher, Susan J.

doi:10.1007/978-1-4612-2718-2_7

Cited by 3 publications

(2 citation statements)

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“…Meanwhile, some of the extravillous CT (EVCT) cells invade the uterine arteries, which are subsequently remodeled to form the uteroplacental arteries (Loke & King 1996, Popek 1999. The invasion performed by EVCT cells is precisely controlled both spatially and temporally (Graham & Lala 1991), and any failure of the normal controlling mechanism during this process results in pathologic conditions, such as pre-eclampsia and choriocarcinoma (Zhou et al 1993, Berkowitz & Goldstein 1996.…”

Section: Introductionmentioning

confidence: 99%

Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy

Bai

Wang²,

Qin³

et al. 2005

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Matrix metalloproteinases (MMPs) are responsible for extracellular matrix (ECM) degradation, and their functions are regulated by tissue inhibitors of MMPs (TIMPs). The evidence for the roles of MMPs and TIMPs in implantation and placentation has remained insufficient in humans, especially during the early stages. Tubal pregnancy has some similarities to normal intrauterine pregnancy and therefore may provide a unique model for implantation studies. In the present study, the expression of MMP-2, -9 and -14, and TIMP-1, -2 and -3 at the feto -maternal interface during tubal pregnancy was examined by immunohistochemistry and in situ hybridization. We found that MMP-9 and TIMP-1, -2 and -3 are produced by all types of extravillous cytotrophoblast (EVCT) cells, while MMP-2 and -14 mainly exist in distal column cytotrophoblast (CCT) cells and invasive EVCT cells. Meanwhile, the intensity of MMP-14 and TIMP-1 and -2 increased along the invasive pathway toward maternal interstitium. In addition, MMP-2, -9 and -14 and TIMP-1, -2 and -3 were all detected in the villous CT (VCT) cells. Furthermore, both the mRNA level and immunoreactivity of MMP-9, TIMP-1 and -3 increased, while those of TIMP-2 decreased concurrent with the progression of pregnancy during weeks 3-9. The unique expression pattern of various MMPs and TIMPs at the feto-maternal interface suggests that they may have roles in regulating the controlled invasion of trophoblasts during implantation and placentation. Meanwhile, the study provides a better understanding of the mechanisms involved in cellular events during human pregnancy, especially at the initiation stage of implantation.

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Section: Introductionmentioning

confidence: 99%

Dynamic expression of matrix metalloproteinases (MMP-2, -9 and -14) and the tissue inhibitors of MMPs (TIMP-1, -2 and -3) at the implantation site during tubal pregnancy

Bai

Wang²,

Qin³

et al. 2005

Reproduction

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“…Bu sonuçlar› destekler flekilde Madazl› ve arkadafllar› preeklampsi ve IUGR ile komplike olmufl gebeliklerde hem maternal hemde fetal yüzdeden al›nan örneklerdeki lenfositlerde afl›r› aktivasyonun bir göstergesi olarak yüzey adhezyon molekülü ICAM-3 ekspresyonunun artt›¤›n› ve yine bu gebeliklerde artm›fl plasental apoptozisi göstermifllerdir (8) . benzeterek vasküler invazyonu baflarabilirken, preeklampside sitotrofoblastlar vasküler adhezyon fenotipini taklit edememektedir (9) . Sonuçta anormal (10) .…”

Section: Geçirimli Elektron Mikroskopisi [Transmission Electron Microscopy (Tem)]unclassified