Cytotoxische und mitosehemmende Wirkung des Anthracyclin-Antibioticums Violamycin

Seeber, C; Fleck, W. F.

doi:10.1002/jobm.3630140607

Cited by 5 publications

(2 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…I n group I1 the red-pigments are antibiotic complexes containing components inducing specific phenomena in the BIP test and reducing growth of the solid sarcoma 180 (GLIWICE) in mice significantly. A member of the antibiotics in group I1 is the new anthracycline antibiotic violamycin mainly belonging t o the epsilon-, zeta-isorhodomycinone-and epsilon-, zeta-and (alpha),-rhodomycinone-glycosides , SEEBER and FLECK 1974, FLECK 1974.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Fleck

Strauss

1975

J of Basic Microbiology

Self Cite

View full text Add to dashboard Cite

A Streptomyces strain belonging to S. griseus (KRAINSKI) WAKSMAN et HENRICI 1948 sensu HUTTER (1967) was found to produce an antitumor antibiotic designated as leukaemomycin. The red-pigment antibiotic, having antimicrobial and antitumor activity in vitro and in vivo, was isolated from C-, N-, and Fe-containing cultures of the strains IMET J A 3933, IMET J A 5570, IMET J A 10086, and IMET J A 10431. Leukaemomycin has indicator properties and is produced by the classic procedures of submerged fermentation. The crude base of leukaemomycin consists of 4 main components, designated as leukaemomycin A, B, C, and D. The biolagical acitivity of the main components leukaemomycin B and C was compared. The biological activity and the physicochemicel properties of leukaemomycin C are identioal with known properties of the anthracycline antibiotic daunorubicin. Leukaeniomycin, obtained from cultures of Streptvmyces griseus, is a basic antibiotic, orange-red in colour, belonging to the group studied by OLLIS and SUTHERLAND (1961). This group of pigment-antibiotics with indicator properties, named anthracyclines by BROCKMANN (1963), includes among others the rhodomycins (BROCKMANN und BAUER 1950), the isorhodomycins (BROCKMANN und PATT 1955), the aklavins (STRE-LITZ et al. 1956), the cinerubins (ETTLINGER et al. 1959), the pyrromycins (BROCKMANN und LENK 1959), and the rutilantin (ASHESHOV and GORDON 1961), most of which possess cytostatic properties. Chemical studies have shown that leukaemomycinconsists of a mixture of the three main components leukaemomycin B, C, and Dwith activity against microorganisms, viruses, and tumors of animalsand the component leukaemomycin A consisting of the biologically inactive aglycones (leukaemomycinones) of the daunomycinone-type. Of the three components of leukaemomycin with biodynamic activity, the most interesting has become known as leukaemomycin C. I t s properties and its action on various microorganisms, viruses, and experimental tumors were identical with the properties of the well-known antitumor antibiotic, which was isolated from S. peucetius (GREIN et al. 1963) and called daunomycin (DIMA~CO et al. 1963). Identical substances were isolated from 8. coeruleorub~dus (DUBOST et al. 1963, PREOBRASHENSKAYA et al. 1966) and designated rubidomycin (BERNARD et al. 19G7) and rubomycin C, respectively (BRAZHNIKOVA et al. 1966).Daunorubicinl) appears to exert its biological effect by interfering with nucleic acid metabolism (THEOLOGIDES et al. 1967). It has been suggested that daunorubicin interferes with the cell cycle during the G, period, thus delaying mitosis in cells which have already synthesized DNA (WHANO-PENG et al. 1969). The antimicrobial activity and the mode of action of daunorubicin and related antibiotics are summarized by DIMARCO (1967). A metabolic transformation of daunorubicin was reported by DIl) The international generic name of daunomycin and rubidom ycin 34 Zeitschdft f. Allg. Mikrobiologie, Bd. 15, € I .7

show abstract

Section: Methodsmentioning

confidence: 99%

“…The methods used are described by SEEBER and FLECK (1974). The cytotoxic minimal concentration (MIC) of leukaemomycin C in primary cell strains (struma cells) amounts to 0.5 mcg/ml, but in permanent cell !ines (HeLa-, PN-, FL-cell lines) from 0.5 to 1.0 mcg/ml.…”

Section: Y T O T O X I C a N D A N T I M I T O T I C A C T I V I T Ymentioning

confidence: 99%

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Fleck

Strauss

1975

J of Basic Microbiology

Self Cite

View full text Add to dashboard Cite

show abstract

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Fleck

Strauss

1975

Z Allg Mikrobiol

View full text Add to dashboard Cite

A Streptomyces strain belonging to S. griseus (Krainski) Waksman et Henrici 1948 sensu Hütter (1967) was found to produce an antibiotic designated as leukaemomycin. The red-pigment antibiotic, having antimicrobial and antitumor activity in vitro and in vivo, was isolated from C-, N-, and Fe-containing cultures of the strains IMET JA 3933, IMET JA 5570, IMET JA 10086, and IMET JA 10431. Leukaemomycin has indicator properties and is produced by the classic procedures of submerged fermentation. The crude base of leukaemomycin consists of 4 main components, designated as leukaemomycin A, B, C, and D. The biological activity of the main components leukaemomycin B and C was compared. The biological activity and the physicochemical properties of leukaemomycin C are identical with known properties of the anthracycline antibiotic daunorubicin.

show abstract

Naturally Occurring Anthracyclines

Laatsch

Fotso

2008

Anthracycline Chemistry and Biology I

View full text Add to dashboard Cite

Cytotoxische und mitosehemmende Wirkung des Anthracyclin-Antibioticums Violamycin

Cited by 5 publications

References 19 publications

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Leukaemomycin, an antibiotic with antitumor activity. I. Screening, fermentation, and biological activity

Naturally Occurring Anthracyclines

Contact Info

Product

Resources

About