Cytotoxicity study of some Ti alloys used as biomaterial

Donato, Tatiani Ayako Goto; Almeida, Luciano Henrique de; Nogueira, R. A.; Niemeyer, Terlize Cristina; Grandini, Carlos Roberto; Caram, Rubens; Schneider, S.; Santos, Arnaldo Rodrigues

doi:10.1016/j.msec.2008.10.021

Cited by 68 publications

(51 citation statements)

References 28 publications

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“…236 For example, Al and V were associated to adverse reactions in tissues and neurological disorders. 237 In addition, high levels of Cr, Ni and Co raise the risk of carcinogenicity. 236 While these effects are known, it is important to point out that the links between a precise concentration of metallic ions and adverse phenomena such as DNA damage, DNA mutation, carcinogenicity and metal sensitivity have not yet been unequivocally established, 235 and further studies are thus required.…”

Section: In Vivo and Clinical Applicationsmentioning

confidence: 99%

Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives

et al. 2011

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Evidence that nanoscale surface properties stimulate and guide various molecular and biological processes at the implant/tissue interface is fostering a new trend in designing implantable metals. Cutting-edge expertise and techniques drawn from widely separated fields, such as nanotechnology, materials engineering and biology, have been advantageously exploited to nanoengineer surfaces in ways that control and direct these processes in predictable manners. In this review, we present and discuss the state-of-the-art of nanotechnology-based approaches currently used to modify the surface of metals used for orthopedic and dental applications, and also briefly consider their use in the cardiovascular field. The effects of nanoengineered surfaces on various in vitro molecular and cellular events are firstly discussed. Importantly, this review also provides an overview of in vivo and clinical studies with nanostructured metallic implants, and addresses the potential influence of nanotopography on biomechanical events at interfaces. Ultimately the objective of this work is to give the readership a comprehensive picture of the current advances, future developments and challenges in the application of the infinitesimally small to biomedical surface science. We believe that an integrated understanding of the in vitro and particularly of the in vivo behavior is mandatory for the proper exploitation of nanostructured implantable metals and, as a matter of fact, all biomaterials.

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Section: In Vivo and Clinical Applicationsmentioning

confidence: 99%

Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives

et al. 2011

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“…These results, with those of cellular viability, suggest that the prepared alloy did not present any type of cytotoxic effect, i.e., it did not cause interference in the cellular growth or viability. Moreover, it did not cause any modifi cation in the cell morphology or in its adhesion to the material surface 15,27 . …”

Section: Resultsmentioning

confidence: 96%

“…The modified MTT 15 assesses the reduction ability of tetrazolium salt (3-bromide [4,5-dimetilthiazol-2-yl]-2,5-difeniltetrazólio) (MTT, 5 mg.mL -1 PBS -Sigma-Aldrich) by the mitochondrial enzyme Succinato desidrogenases to fromazan crystals at the end of the reaction. Since the MTT is a colorimetric test, the yellow MTT solution changes to purple when it reacts with the mitochondrial enzyme.…”

Section: Experimental Partmentioning

confidence: 99%

Preparation and characterization of Ti-15Mo alloy used as biomaterial

et al. 2011

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With the increase in life expectancy, biomaterials have become an increasingly important focus of research because they are used to replace parts and functions of the human body, thus contributing to improved quality of life. In the development of new biomaterials, the Ti-15Mo alloy is particularly significant. In this study, the Ti-15Mo alloy was produced using an arc-melting furnace and then characterized by density, X-ray diffraction, optical microscopy, hardness and dynamic elasticity modulus measurements, and cytotoxicity tests. The microstructure was obtained with β predominance. Microhardness, elasticity modulus, and cytotoxicity testing results showed that this material has great potential for use as biomaterial, mainly in orthopedic applications.

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“…Percebe-se que as células na superfície das amostras estão planas e aderidas ao material, sem sinais de degeneração celular, indicando que o material não é tóxico e permite a proliferação celular em sua superfície, requisito importante na aplicação como biomaterial. A Figura 72 apresenta micrografias muito parecidas com as publicadas por DONATO e colaboradores [74]. …”

Section: Iv6 Biocompatibilidadeunclassified

Influência da dopagem com oxigênio nas propriedades anelásticas e biocompatibilidade de ligas Ti-5%pNb e Ti-10%pNb

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Cytotoxicity study of some Ti alloys used as biomaterial

Cited by 68 publications

References 28 publications

Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives

Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives

Preparation and characterization of Ti-15Mo alloy used as biomaterial

Influência da dopagem com oxigênio nas propriedades anelásticas e biocompatibilidade de ligas Ti-5%pNb e Ti-10%pNb

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