Cytotoxicity study of plant Aloe vera (Linn)

Chandu, Atul N; Kumar, Santhosh C; Bhattacharjee, Chiranjib; Debnath, Subhas Chandra

doi:10.4103/2229-5186.99595

Cited by 12 publications

(3 citation statements)

References 3 publications

(5 reference statements)

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“…Q4 Q4 cells (Chandu et al 2012). To our knowledge, this is the first study dealing with the mechanism of AVG and AE cytotoxicity.…”

Section: 04%mentioning

confidence: 85%

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2018

Istanbul J Pharm

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Known for centuries as a "wonder" plant, Aloe vera (L.) Burm. f. has many biological and pharmacological activities. These effects are due to the variety of the chemical compounds including anthraquinones, glycoproteins, polysaccharides, vitamins and enzymes contained (Choi and Chung 2003; Du Plessis and Hamman 2014; Akev et al. 2015; Shrestha et al. 2015). Many of the medicinal effects have also been attributed to the immunomodulatory properties of the inner gel (Im et al. 2010), but it is also believed that synergistic action of the compounds contained in the whole leaf extracts is responsible for the multiple and diverse beneficial properties of the plant (Eshun and He 2004). The mucilageneous gel part of A. vera is used commercially as a softener in various cosmetic preparations, soaps and shampoos due to its glycoprotein content. The first known effects of A. vera after its cathartic activity, is the wound and burn healing effect of the leaves gel portion, widely supported in scientific literature (Capasso et al. 1998; Chithra et al. 1998; Heggers et al. 1995). Because of this effect, the gel is also added to many preparations used for skin treatment. Antitumor and cytotoxic potential of A. vera extracts continues to be the interest of scientific research from 1980's (Winters et al. 1981; Tsuda et al. 1993; Corsi et al. 1998) until recent years (Naveena Bharath and Selvasubramanian 2011; Du Plessis and Hamman 2014). In a research undertaken in our laboratory, A. vera leaf skin aqueous extract was proved to be effective as prophylactic against Ehrlich ascites tumours in vivo (Akev et al. 2007). The Food and Drug Administration of the USA has approved the developmental study of A. vera for the treatment of cancer and AIDS (Nandal and Bhardwaj 2012). Antitumor effect of aloe emodin (AE), the major anthraquinone derivative of A. vera, was reported in recent years (Cárdenas et al. 2006; Lee et al. 2006; Lin et al. 2006) and attention has been given recently to the possibility of utilizing AE as a chemothera

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“…Q4 Q4 cells (Chandu et al 2012). To our knowledge, this is the first study dealing with the mechanism of AVG and AE cytotoxicity.…”

Section: 04%mentioning

confidence: 85%

Untitled

2018

Istanbul J Pharm

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“…8 Another group of researchers demonstrated a greater cytotoxic effect of aloe vera gel at a 300 µg/mL concentration on melanoma human cancer cell line B16F10. 9 MCF-7, a human breast cancer cell line was found to have stronger cytotoxicity with flavonoids derived from aloe vera gel at an IC50 of 54.97 ± 0.36 µg/mL. 10 These are some of the reported works which suggest that aloe vera is truly a wonder plant in the field of cancer therapy.…”

Section: Introductionmentioning

confidence: 91%

Anticancer potential of poly(2-aminobenzoic acid)-blend-Aloe vera against the human breast cancer cell line MDA-MB-231

Sebastian¹,

Mary

2022

Journal of Bioactive and Compatible Polymers

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Breast cancer in women is amongst the most significant concerns from time immemorial in the field of oncology. This study proposes an anticancerous polymeric material based on an electroactive substituted polyaniline blend, poly(2-aminobenzoic acid)-blend-Aloe vera (PABA/AV) synthesized by the emulsion polymerization method. The structural, thermal, and morphological characteristics determined using FT-IR and UV-Visible Spectroscopy, XRD, TGA, DTA, and SEM-EDX validated the thermally stable, semi-crystalline, emeraldine salt structure. The material is semi-conducting, and the electrical conductivity measured is 1.86 × 10−3 S/cm. It shows bactericidal efficacy against Enterococcus faecalis at a minimum inhibitory and minimum bactericidal concentration of 50 μg/mL. The radical cations in the emeraldine polymer chain reduce the 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and exhibit a significant % of DPPH scavenging (89.85%) at 20 μL. The polymer blend is active against the human breast cancer cell line MDA-MB-231 and causes 78.65% cytotoxicity at a concentration of 125 μg/mL. The synergistic effect of the ancient healing Aloe vera plant and the electroactive biocompatible poly(2-aminobenzoic acid) certainly opens up new developments in the field of cancer therapy.

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“…Aloe is a plant that is well-known for its medicinal properties and specifically for applications, such as wound healing, as a laxative and for the treatment of skin irritations [26]. Murine melanoma cells were treated with saline extracts of Aloe vera and was it observed that such treatments had reduced cell viability in a concentration dependent manner [234]. Emodin, an active component of Aloe, is a natural hydroxyanthraquinone, which has been studied for its possible anti-melanoma properties.…”

Section: Anti-melanoma Activity Of Crude Plant Extractsmentioning

confidence: 99%

Review of Natural Compounds for Potential Skin Cancer Treatment

et al. 2014

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Most anti-cancer drugs are derived from natural resources such as marine, microbial and botanical sources. Cutaneous malignant melanoma is the most aggressive form of skin cancer, with a high mortality rate. Various treatments for malignant melanoma are available, but due to the development of multi-drug resistance, current or emerging chemotherapies have a relatively low success rates. This emphasizes the importance of discovering new compounds that are both safe and effective against melanoma. In vitro testing of melanoma cell lines and murine melanoma models offers the opportunity for identifying mechanisms of action of plant derived compounds and extracts. Common anti-melanoma effects of natural compounds include potentiating apoptosis, inhibiting cell proliferation and inhibiting metastasis. There are different mechanisms and pathways responsible for anti-melanoma actions of medicinal compounds such as promotion of caspase activity, inhibition of angiogenesis and inhibition of the effects of tumor promoting proteins such as PI3-K, Bcl-2, STAT3 and MMPs. This review thus aims at providing an overview of anti-cancer compounds, derived from natural sources, that are currently used in cancer chemotherapies, or that have been reported to show anti-melanoma, or anti-skin cancer activities. Phytochemicals that are discussed in this review include flavonoids, carotenoids, terpenoids, vitamins, sulforaphane, some polyphenols and crude plant extracts.

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Cytotoxicity study of plant Aloe vera (Linn)

Cited by 12 publications

References 3 publications

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Anticancer potential of poly(2-aminobenzoic acid)-blend-Aloe vera against the human breast cancer cell line MDA-MB-231

Review of Natural Compounds for Potential Skin Cancer Treatment

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