Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines

Tammina, Sai Kumar; Mandal, Badal Kumar; Ranjan, Shivendu; Dasgupta, Nandita

doi:10.1016/j.jphotobiol.2016.11.017

Cited by 135 publications

(38 citation statements)

References 61 publications

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“…The tin oxide nanoparticle formation can be confirmed by the presence of peaks at 435, 515, and 622 cm −1 for the symmetric and asymmetric vibrations of Sn‐O‐Sn. The presence of these peaks, with a small difference in wavenumber, have been reported previously for biosynthetic SnNPs . The presence of secondary metabolites, which are responsible for the capping and reduction of the tin chloride precursor to SnNPs, has been studied using FT‐IR.…”

Section: Resultsmentioning

confidence: 59%

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Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Ahmeda

Mahdavi

Zaker

et al. 2020

Applied Organom Chemis

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The therapeutic properties of tin nanoparticles have been proved in recent years. One of their probable effects is anti‐anemia. In this study, tin nanoparticles were synthesized and characterized in aqueous medium using Ziziphora clinopodioides Lam leaf aqueous extract as the reducing and stabilizing agent. We also assessed the antihemolytic anemia potential of tin nanoparticles (SnNPs) in an animal model of hemolytic anemia. Tin nanoparticles were characterized using many techniques including Fourier transform‐infrared and UV‐visible spectroscopy, X‐ray diffraction (XRD), energy dispersive X‐ray spectrometry, and field emission‐scanning electron microscopy (FE‐SEM). FE‐SEM images showed a uniform spherical morphology in size of 18.12 nm for the green synthesized nanoparticles. According to XRD analysis, SnNPs crystal size was17.94 nm. SnNPs had low cell viability dose‐dependently against human umbilical vein endothelial cell line. in vivo design, induction of hemolytic anemia was done by phenylhydrazine in 40 mice. Tin nanoparticles significantly (p ≤ 0.01) reduced the weight and volume of liver and spleen and the concentration of pro‐inflammatory cytokines, and increased the body weight, anti‐inflammatory cytokines concentration, total platelet, WBC, neutrophil, lymphocyte, eosinophil, monocyte, and basophil counts, and red blood cell parameters compared to the untreated mice. For the biochemical parameters, SnNPs significantly (p ≤ 0.01) increased the concentrations of GPx, CAT, and SOD in serum, liver, and spleen and decreased the concentration of GR in serum, liver, and spleen, and also erythropoietin, ferritin, and ferrous in serum as compared to the anemic mice. The 2,2‐diphenyl‐1‐picrylhydrazyl test showed similar antioxidant activities for SnNPs and butylated hydroxytoluene. The results demonstrate the excellent antihemolytic anemia, hematoprotective, cytotoxicity, and antioxidant potentials of SnNPs compared to other experimental groups.

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Section: Resultsmentioning

confidence: 59%

“…In our review of the literature, different sizes were reported for SnNPs biosynthesized using plants extracts, for example 30–40 nm for Litsea cubeba fruits, 47 nm for C. spinosa , 8.85 nm for P. nigrum , 9 nm for Pruni spinosae flos extract, 1–4.5 nm for Aspalathus linearis , and 20–40 nm for Cleistanthus collinus.…”

Section: Resultsmentioning

confidence: 99%

Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Ahmeda

Mahdavi

Zaker

et al. 2020

Applied Organom Chemis

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“…Moreover, it was found that SnO 2 shows both antioxidant 46,47,52 and anticancer activities. 53,54 The evaluation of the applicability and stability of Ag@SnO 2 in a biological environment was carried out in TBS solution at 0.1 M (pH 7.4, HCl). As a non-toxic, isotonic buffer that maintains the pH value in a relatively narrow range of 7 to 9.2, TBS is commonly used for many biochemical techniques and studies.…”

Section: Resultsmentioning

confidence: 99%

Facile synthesis of SnO₂shell followed by microwave treatment for high environmental stability of Ag nanoparticles

et al. 2020

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“…This makes it very challenging to develop nano-based drugs or targeting moieties as the information pertaining to it is limited. Usually, drugs are tested on animal models like rats, mice or rabbits, but the same physiology and drug interaction is hardly applicable to the human body [94][95][96][97][98][99]. This increases the chances of failure of the drug or might result in the drug reaching untargeted sites.…”

Section: Challengesmentioning

confidence: 99%

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Shukla

Dasgupta

Ranjan

et al. 2017

Biotechnology & Biotechnological Equipment

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The application of nanotechnology in medicine, diagnostics, therapeutics, drug delivery, etc. in order to overcome the limitations faced by these fields has already been established. Anaemia and osteoporosis are two of the most widely prevalent iron and calcium deficiency diseases among women. Conventional drugs for both have their inherent limitations which can be overcome by nanotechnology. Nanonization of drugs has been established as a very efficient way to enhance the bioavailability and absorption of the drug in the gastrointestinal tract. In addition to this, encapsulation of drugs in solid lipid nanoparticles is also employed to increase the stability of the drug in the gastrointestinal tract and to facilitate its controlled release. Nanotechnology is also applied in bone tissue engineering to prepare bone grafts for bone injury. Nanotechnology-based bone grafts have shown to possess enhanced mechanical properties and better biocompatibility and osteoconduction than the conventional bone grafts. This review article highlights the research trends and challenges of nanotechnology based drugs to combat iron deficiency anaemia and osteoporosis. This review outlines the recent research trends in nano-drugs and touches on issues concerning the market, industries and patents pertaining to drugs for anaemia and osteoporosis. To provide the safety and risk factors of nanomaterials, we have briefly highlighted the toxicological aspects of nanomaterials used in drugs.

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Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines

Cited by 135 publications

References 61 publications

Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Facile synthesis of SnO₂shell followed by microwave treatment for high environmental stability of Ag nanoparticles

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

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Cytotoxicity study of Piper nigrum seed mediated synthesized SnO2 nanoparticles towards colorectal (HCT116) and lung cancer (A549) cell lines

Cited by 135 publications

References 61 publications

Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Chemical characterization and anti‐hemolytic anemia potentials of tin nanoparticles synthesized by a green approach for bioremediation applications

Facile synthesis of SnO2shell followed by microwave treatment for high environmental stability of Ag nanoparticles

Nanotechnology towards prevention of anaemia and osteoporosis: from concept to market

Contact Info

Product

Resources

About

Facile synthesis of SnO₂shell followed by microwave treatment for high environmental stability of Ag nanoparticles