Cytotoxicity of ultraviolet-C radiation on a heterogeneous population of human glioblastoma multiforme cells: Meta-analysis

Pronin, Savva; Koh, Chan Hee; Hughes, Mark

doi:10.1016/j.pdpdt.2018.10.003

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Coral-derived sinularin [ 16 ] and brown-algae-derived fucoidan [ 20 ] showed more substantial antiproliferation effects against oral cancer cells when combined with UVC irradiation. Notably, combined treatments of UVC/sinularin [ 13 ] or UVC/fucoidan [ 17 ] showed higher antiproliferation effects in oral cancer than in normal cells. Similarly, PHA induced greater antiproliferation effects in oral cancer than normal cells [ 27 ], providing evidence of the preferential-antiproliferation property of PHA.…”

Section: Discussionmentioning

confidence: 99%

“…Several natural products, such as sinularin [ 13 ] and fucoidan [ 17 ], have demonstrated the ability to generate oxidative stress. UVC also exhibits the same capacity [ 30 , 45 , 46 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

“…Several natural products have been reported in combined treatment with radiotherapy [ 10 , 11 ] to alleviate resistance or adverse effects and improve cancer treatment [ 12 , 13 ]. In addition to ionizing radiation (X-rays), non-ionizing radiation such as ultraviolet-C (UVC) also exhibits antiproliferation effects on several cancer types, such as pancreatic [ 14 ], colon [ 15 ], oral [ 16 ], and glioblastoma multiforme [ 17 ] cancer cells. UVC was combined with several clinical drugs [ 18 , 19 ] and natural products [ 16 , 20 ] to demonstrate anticancer effects.…”

Section: Introductionmentioning

confidence: 99%

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Combined Treatment (Ultraviolet-C/Physapruin A) Enhances Antiproliferation and Oxidative-Stress-Associated Mechanism in Oral Cancer Cells

et al. 2022

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Physapruin A (PHA), a Physalis peruviana-derived withanolide, exhibits antiproliferation activity against oral and breast cancer cells. However, its potential antitumor effects in combined treatments remain unclear. This investigation focused on evaluating the impact of the combined treatment of ultraviolet-C with PHA (UVC/PHA) on the proliferation of oral cancer cells. The UVC-caused antiproliferation was enhanced by combination with PHA in oral cancer (Ca9-22 and CAL 27) but not normal cells (SG), as evidenced by ATP detection, compared with UVC or PHA alone. UVC/PHA showed a greater extent of subG1 increase, G2/M arrest, annexin-V-assessed apoptosis, caspase 3/7 activation, and reactive oxygen species (ROS) in the UVC or PHA treatment of oral cancer compared to normal cells. Moreover, the mitochondrial functions, such as mitochondrial superoxide bursts and mitochondrial membrane potential destruction, of oral cancer cells were also enhanced by UVC/PHA compared to UVC or PHA alone. These oxidative stresses triggered γH2AX and 8-hydroxyl-2’-deoxyguanosine-assessed DNA damage to a greater extent under UVC/PHA treatment than under UVC or PHA treatment alone. The ROS inhibitor N-acetylcysteine reversed all these UVC/PHA-promoted changes. In conclusion, UVC/PHA is a promising strategy for decreasing the proliferation of oral cancer cells but shows no inhibitory effect on normal cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combined Treatment (Ultraviolet-C/Physapruin A) Enhances Antiproliferation and Oxidative-Stress-Associated Mechanism in Oral Cancer Cells

et al. 2022

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“…UVC irradiation may be effortlessly operated in the clinic, rather than the medical center. UVC exposure shows translational potential to inhibit the proliferation of glioblastoma multiforme cancer cells [ 12 ]. The combined treatments of clinical drugs [ 13 , 14 ], chemical agents [ 15 ], or natural products [ 16 , 17 ] with UVC irradiation may improve the antiproliferation of several types of cancer cells.…”

Section: Introductionmentioning

confidence: 99%

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells

Peng

Tang

et al. 2021

Cancers

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Combined treatment is increasingly used to improve cancer therapy. Non-ionizing radiation ultraviolet-C (UVC) and sinularin, a coral Sinularia flexibilis-derived cembranolide, were separately reported to provide an antiproliferation function to some kinds of cancer cells. However, an antiproliferation function using the combined treatment of UVC/sinularin has not been investigated as yet. This study aimed to examine the combined antiproliferation function and explore the combination of UVC/sinularin in oral cancer cells compared to normal oral cells. Regarding cell viability, UVC/sinularin displays the synergistic and selective killing of two oral cancer cell lines, but remains non-effective for normal oral cell lines compared to treatments in terms of MTS and ATP assays. In tests using the flow cytometry, luminescence, and Western blotting methods, UVC/sinularin-treated oral cancer cells exhibited higher reactive oxygen species production, mitochondrial superoxide generation, mitochondrial membrane potential destruction, annexin V, pan-caspase, caspase 3/7, and cleaved-poly (ADP-ribose) polymerase expressions than that in normal oral cells. Accordingly, oxidative stress and apoptosis are highly induced in a combined UVC/sinularin treatment. Moreover, UVC/sinularin treatment provides higher G2/M arrest and γH2AX/8-hydroxyl-2′deoxyguanosine-detected DNA damages in oral cancer cells than in the separate treatments. A pretreatment can revert all of these changes of UVC/sinularin treatment with the antioxidant N-acetylcysteine. Taken together, UVC/sinularin acting upon oral cancer cells exhibits a synergistic and selective antiproliferation ability involving oxidative stress-dependent apoptosis and cellular DNA damage with low toxic side effects on normal oral cells.

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Phototherapy for age-related brain diseases: Challenges, successes and future

Ding,

Gu,

Chen

et al. 2024

Ageing Research Reviews

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Cytotoxicity of ultraviolet-C radiation on a heterogeneous population of human glioblastoma multiforme cells: Meta-analysis

Cited by 5 publications

References 30 publications

Combined Treatment (Ultraviolet-C/Physapruin A) Enhances Antiproliferation and Oxidative-Stress-Associated Mechanism in Oral Cancer Cells

Combined Treatment (Ultraviolet-C/Physapruin A) Enhances Antiproliferation and Oxidative-Stress-Associated Mechanism in Oral Cancer Cells

Oxidative Stress-Dependent Synergistic Antiproliferation, Apoptosis, and DNA Damage of Ultraviolet-C and Coral-Derived Sinularin Combined Treatment for Oral Cancer Cells

Phototherapy for age-related brain diseases: Challenges, successes and future

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