Cytotoxicity of the Diethyldithiocarbamate Anion, of its S-Methylester and of Respective Platinum (II) Complexes

Carrara, Maria; Cima, L.; Zampiron, S.; Nicolini, M.; Sindellari, L.; Trincia, L.

doi:10.1007/978-1-4613-1717-3_29

Cited by 4 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[12] Organotin compounds have received a great deal of attention in terms of their potential as anti-tumour agents but as yet none have entered clinical trials. [13] Building upon earlier work, [14] a series of phenyltin dithiocarbamates were evaluated for their cytotoxicity against L1210 mouse leukaemia cell lines. [15] It was found that the series of compounds Ph 4 n Sn(S 2 CNEt 2 ) n , for n D 1-3, gave a 50% growth inhibition ratings of 0.3 µM compared with 0.6 and 1.2 µM for the drugs cisplatin and carboplatin, respectively.…”

Section: Biological Activitiesmentioning

confidence: 99%

Tin dithiocarbamates: applications and structures

Tiekink

2008

Applied Organom Chemis

190

153

View full text Add to dashboard Cite

The uses and potential utility of tin/organotin dithiocarbamate, − S 2 CNR 2 , compounds are reviewed. Various derivatives exhibit exciting potential as anti-cancer agents, anti-microbial agents and insecticides, e.g. against mosquito larvae. Tin dithiocarbamates have also proven useful as precursors for tin sulfide nanoparticles. There is a wealth of structural data available for such compounds and with the exception of the diorganotin bis(dithiocarbamate) compounds, R 2 Sn(S 2 CNR 2 ) 2 , compounds for which different structural motifs are evident, there is a certain degree of homogeneity in the molecular structures for each class of compound unless there are additional coordination sites on the R and/or R groups. Owing to the strong coordination potential of the dithiocarbamate ligand for tin, supramolecular aggregates involving secondary Sn· · ·S interactions are the exception rather than the norm.

show abstract

Section: Biological Activitiesmentioning

confidence: 99%

Tin dithiocarbamates: applications and structures

Tiekink

2008

Applied Organom Chemis

190

153

View full text Add to dashboard Cite

show abstract

“…In 1979, Cisplatin became the first platinum-based drug approved for cancer chemotherapy and remains one of the most widely used antitumor drugs in the treatment of, e.g., testicular, ovarian, and lung cancer. − However, its clinical use is restricted by significant side effects and the development of Cisplatin resistance in cancer cells. − …”

Section: Introductionmentioning

confidence: 99%

Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor- Positive Tumor Cells

Grabher,

Kapitza,

Hörmann

et al. 2024

J. Med. Chem.

View full text Add to dashboard Cite

but-1-enyl)phenyl)acrylic acid (GW7604) as a carrier was esterified with alkenols of various lengths and coordinated through the ethylene moiety to PtCl 3 , similar to Zeise's salt (K-[PtCl 3 (C 2 H 4 )]). The resulting GW7604-Alk-PtCl 3 complexes (Alk = Prop, But, Pent, Hex) degraded in aqueous solution only by exchange of the chlorido ligands. For example, GW7604-Pent-PtCl 3 coordinated the amino acid alanine in the cell culture medium, bound the isolated nucleotide 5′-GMP, and interacted with the DNA (empty plasmid pSport1). It accumulated in estrogen receptor (ER)-positive MCF-7 cells primarily via cytosolic vesicles, while it was only marginally taken up in ER-negative SKBr3 cells. Accordingly, GW7604-Pent-PtCl 3 and related complexes were inactive in SKBr3 cells. GW7604-Pent-PtCl 3 showed high affinity to ERα and ERβ without mediating agonistic or ER downregulating properties. GW7604-Alk ligands also increased the cyclooxygenase (COX)-2 inhibitory potency of the complexes. In contrast to Zeise's salt, the GW7604-Alk-PtCl 3 complexes inhibited COX-1 and COX-2 to the same extent.

show abstract

“…Other newly synthesized Pt(II)-based anticancer drugs viz. carboplatin, nedaplatin, lobaplatin, and oxaliplatin are not as successful as cisplatin due to severe side effects and no longer have the clinical advantages. , Moreover, inherent and acquired resistances have marred the success of cisplatin and limited its efficacy during chemotherapy . The adverse effect of Pt(II)-based anticancer drugs leads the attention toward the less toxic but similar efficacy of Pd(II) complexes showing iso-structural pattern (square planar) and analogues with Pt(II) complexes. , Moreover, Pd(II) complexes could attain rapid equilibrium in comparison to Pt(II) (10 5 times faster) , analogues which might be applied as a model complex for studying the mechanism of interaction of Pt-analogues with DNA …”

Section: Introductionmentioning

confidence: 99%

Synthesis, Kinetics, Reaction Mechanism, and Bioactivity Assays of a Dimeric Palladium Complex

Dey,

Kumar,

Dutta

et al. 2023

ACS Omega

View full text Add to dashboard Cite

Cytotoxicity of the Diethyldithiocarbamate Anion, of its S-Methylester and of Respective Platinum (II) Complexes

Cited by 4 publications

References 5 publications

Tin dithiocarbamates: applications and structures

Tin dithiocarbamates: applications and structures

Development of Cytotoxic GW7604-Zeise’s Salt Conjugates as Multitarget Compounds with Selectivity for Estrogen Receptor- Positive Tumor Cells

Synthesis, Kinetics, Reaction Mechanism, and Bioactivity Assays of a Dimeric Palladium Complex

Contact Info

Product

Resources

About