Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N′-di-3-propionato ligand

Sabo, Tibor J.; Kaluđerović, Goran N.; Poleti, Dejan; Karanović, Ljiljana; Boccarelli, Angelina; Cannito, Francesco; Natile, Giovanni

doi:10.1016/j.jinorgbio.2004.04.023

Cited by 24 publications

(17 citation statements)

References 18 publications

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“…All of them induce apoptosis and their effect is dose-dependent. Platinum(II) complexes with bidentate edda ligand type [PtCl 2 (R 2 edda)] (R = Me, Et, n-Pr; edda = ethylenediamine-N, N'-diacetate) were also questioned (48). In vitro cytotoxic effect was studied on various cell lines to generate new evidence regarding the cytotoxic effect of these complexes, ( Table 1).…”

Section: Cytotoxicity Of Platinum Complexes With Eddatype Ligandsmentioning

confidence: 99%

Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

Jurišević

Radosavljević

Arsenijević

et al. 2016

Serbian Journal of Experimental and Clinical Research

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Section: Cytotoxicity Of Platinum Complexes With Eddatype Ligandsmentioning

confidence: 99%

Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

Jurišević

Radosavljević

Arsenijević

et al. 2016

Serbian Journal of Experimental and Clinical Research

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“…5,6 In the present study, we tested the in vitro antitumor activity of several recently described Pt(II) and Pt(IV) complexes. [7][8][9][10][11][12] The complexes 1-4, [Pt(ONNO)X 2 ] (ONNO 5 pdda-propylenediamine-N,N 0 -diacetato or eddp-ethylenediamine-N,N 0 -di-3-propanoato; X 5 Cl or Br ligands), are characterized with X-ray crystallography in order to determine geometrical isomer, which in all cases were trans-halogeno. This configuration permitted us to investigate and compare how the modification of linear tetradentate affects the cytotoxic action.…”

mentioning

confidence: 99%

Novel platinum(IV) complexes induce rapid tumor cell death in vitro

Kaludjerović

Miljković

Momčilović³

et al. 2005

Intl Journal of Cancer

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The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)‐based drug cisplatin. However, Pt(IV) complexes have greater inertness than corresponding Pt(II) complexes, thus allowing the oral administration and reducing the toxicity associated with platinum‐based chemotherapy. Here, we describe the in vitro antitumor activity of some novel Pt(IV)‐based agents against mouse fibrosarcoma L929 cells and human astrocytoma U251 cells. The cytotoxicity of 2 Pt(IV) complexes with bidentate ethylenediamine‐N,N′‐di‐3‐propanoato esters was found to be markedly higher than that of their Pt(II) counterparts and comparable to the antitumor action of cisplatin. In contrast to cisplatin, which caused oxidative stress‐independent apoptotic cell death of tumor cells, these Pt(IV) complexes induced oxygen radical‐mediated tumor cell necrosis. Importantly, the cytotoxic action of novel Pt(IV) complexes was markedly more rapid than that of cisplatin, indicating their potential usefulness in anticancer therapy. © 2005 Wiley‐Liss, Inc.

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“…(1,2-dpheddp) (6) C1−C2 1.534 (7) 1.530 (9) C2−C3 1.515 (7) 1.506 (6) O2−C1 1.233 (6) According to the Cambridge Structural Database (CSD, Version 5.33 of 2012) [17], the present crystal structure is the only example of a palladium(II) complex with eddp derivative. In the case of the other metal atoms, there are two octahedral complexes of platinum(IV) [18,19] and squarepyramidal complex of copper(II) with unmodified eddp ligand [20]. As previously observed in the complexes comprising propionate-chelates [18][19][20][21] the six-membered chelate rings of [Pd(1,2-dpheddp)]·3H 2 O are essentially planar in their carboxylate parts and puckered in their amino parts.…”

Section: Crystal and Molecular Structure Of [Pd(12-dpheddp)]·3h 2 Omentioning

confidence: 79%

“…The presence of voluminous phenyl substituents with dissimilar orientation induce the noticeable difference between N1a-C4a-C4b and N1b-C4b-C4a angles [108.2(4) and 102.9(3)º]. In the complexes comprising unmodified eddp ligand [18][19][20], the distribution of the angles within the ethylenediamine fragment is more consistent (from 106.3 to 108.2º, not including the chelate angle).…”

Section: Selected Bond Lengths (å) and Angles (°) For [Pdmentioning

confidence: 99%

“…Natile and co-workers investigated how the substitution of edda with eddp (eddp = ethylenediamine-N,N'-di-3-propanoate ion) influenced their biological activity and concluded that eddp-Pt(IV) had lower activity than corresponding edda-Pt(IV) complex [7]. They supposed this fact due to the different complex geometry, s-cis in the case of edda and trans in the case of eddp.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxicity of platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid. Crystal structure of [Pd(1,2-dpheddp)] complex

Mijajlović

Nikolić

Jevtić

et al. 2016

Maced. J. Chem. Chem. Eng.

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The syntheses of tetradentate ligand, meso-1, 2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid (H 2 -1,2-dpheddp) and corresponding platinum(IV) and palladium(II) complexes are reported here. The spectroscopically predicted structure of the obtained palladium(II) complex was confirmed by X-ray analysis. Singe crystals suitable for X-ray measurements were obtained by slow crystallization from a DMSO-water mixture. Cytotoxic effects of platinum(IV), palladium(II) complexes and cisplatin on the 4T1 and B16F1 cell lines were determined using the MTT colorimetric technique. The complexes showed a dose dependence on cytotoxic effect toward both cell lines. Both complexes were less active than cisplatin, the exception was concentrations above 62.5 μM of platinum(IV) complex in the B16F1 cell line.Keywords: meso-1, platinum(IV) complex; palladium(II) complex; crystal structure; cytotoxicity ЦИТОТОКСИЧНОСТ НА КОМПЛЕКСИТЕ НА ПЛАТИНА(IV) И ПАЛАДИУМ(II) СО meso-1,2-ДИФЕНИЛ-ЕТИЛЕНДИАМИН-N,N'-ДИ-3-ПРОПАНОНСКА КИСЕЛИНА. КРИСТАЛНА СТРУКТУРА НА КОМПЛЕКСОТ НА [Pd(1,2-dpheddp)]Во овој труд е опишана синтезата на тетрадентатниот лиганд, meso-1,2-дифенил-етилендиамин-N,N'-ди-3-пропанонска киселина (H 2 -1,2-dpheddp), со соодветните комплекси на платина(IV) и паладиум(II). Спектроскопски предвидената структура на добиениот комплекс на паладиум(II) е потврдена со рендгенска структурна анализа. Монокристалите соодветни за рендгенските испитувања се добиени со бавна кристализација од воден раствор на DMSO. Цитотоксичните ефекти на комплексите на платина(IV) и на паладиум(II) врз типови на клетки 4T1 и B16F1 се определени со MTT колориметрија и споредени со соодветните ефекти на цисплатин. Двата комплекса покажаа дозирачки зависен цитотоксичен ефект врз двата типа клетки. Двата комплекса покажаа послаба активност од онаа на цисплатин, со исклучок на повисоките концентрации (над 62,5 μM) на комплексот на платина(IV) спрема клетките B16F1.Клучни зборови: meso-1, 2-дифенил-етилендиамин-N,N'-ди-3-пропанонска киселина; платина(IV)-комплекс; паладиум(II)-комплекс; кристална структура; цитотоксичност M. Ž. Mijajlović et al.

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Cytotoxicity of some platinum(IV) complexes with ethylenediamine-N,N′-di-3-propionato ligand

Cited by 24 publications

References 18 publications

Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

Platinum Complexes with Edda (Ethylenediamine -N, N - Diacetate) Ligands as Potential Anticancer Agents

Novel platinum(IV) complexes induce rapid tumor cell death in vitro

Cytotoxicity of platinum(IV) and palladium(II) complexes with meso-1,2-diphenyl-ethylenediamine-N,N'-di-3-propanoic acid. Crystal structure of [Pd(1,2-dpheddp)] complex

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