Cytotoxicity of nanostructured vanadium oxide on human cells in vitro

Rhoads, Laura S.; Silkworth, William T.; Roppolo, Megan; Whittingham, M. Stanley

doi:10.1016/j.tiv.2009.08.010

Cited by 30 publications

(15 citation statements)

References 22 publications

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“…In other metal oxide studies, significant cytotoxicity was observed, but the contribution of free metal ions was not considered (Gerloff et al, 2009; Koeneman et al, 2010; Rhoads et al, 2010; Rodriguez-Luccioni et al, 2011). …”

Section: In Vitro Studies Of Np Toxicitymentioning

confidence: 99%

Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps

Bergin¹,

Witzmann²

2013

IJBNN

321

201

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The increasing interest in nanoparticles for advanced technologies, consumer products, and biomedical applications has led to great excitement about potential benefits but also concern over the potential for adverse human health effects. The gastrointestinal tract represents a likely route of entry for many nanomaterials, both directly through intentional ingestion or indirectly via nanoparticle dissolution from food containers or by secondary ingestion of inhaled particles. Additionally, increased utilisation of nanoparticles may lead to increased environmental contamination and unintentional ingestion via water, food animals, or fish. The gastrointestinal tract is a site of complex, symbiotic interactions between host cells and the resident microbiome. Accordingly, evaluation of nanoparticles must take into consideration not only absorption and extraintestinal organ accumulation but also the potential for altered gut microbes and the effects of this perturbation on the host. The existing literature was evaluated for evidence of toxicity based on these considerations. Focus was placed on three categories of nanomaterials: nanometals and metal oxides, carbon-based nanoparticles, and polymer/dendrimers with emphasis on those particles of greatest relevance to gastrointestinal exposures.

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Section: In Vitro Studies Of Np Toxicitymentioning

confidence: 99%

Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps

Bergin¹,

Witzmann²

2013

IJBNN

321

201

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“…The mouse fibroblast cell line L929 was cultured in Modified Eagle Medium (MEM) containing 4.5 g/L glucose, 2.0 mM L-glutamine, 2.2 M sodium pyruvate, 10.0 mM N-2-hydroxyethylpiperazine N-2-ethanesulfonic acid (HEPES) buffer, 2.0 g/L sodium bicarbonate, 100 U/mL amphotericin-gentamicin and 10% fetal bovine serum (Sigma, St. Louis, MO, USA) (Rhoads et al, 2010). The fibroblasts was tested on the 7th passage in 80% confluent monolayer.…”

Section: Mammalian Cell Culturementioning

confidence: 99%

“…Cells were plated at a density of 1 Â 10 4 cells/cm 2 , and the medium was changed 24 h later. All animal-related experiments were performed in accordance with the guidelines proposed by the Center for Laboratory Animal Medicine and Care at the University of Texas Health Science Center at Houston (UTHSCH) (Kong et al, 2009;Rhoads et al, 2010;Zhang et al, 2010). The osteoblasts were tested on the 4th passage in 80% confluent monolayer.…”

Section: Mammalian Cell Culturementioning

confidence: 99%

“…A single cell suspension was obtained after trypsinization, and the cells were counted in a hemocytometer (Reichert, Buffalo, NY, USA). Cells were then allowed to attach to the plates for 48 h in a humidified atmosphere containing 5% CO 2 at 37.0 C (Rhoads et al, 2010). The Caco-2 cells were tested on the 30th passage in 80% confluent monolayer.…”

Section: Mammalian Cell Culturementioning

confidence: 99%

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Cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cellsin vitro

et al. 2014

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“…In addition to the use of Caco-2 cells as a screening tool for the assessment of intestinal permeability, these cells have also been used to predict the toxicity of new oral drug candidates and formulation adjuvants in epithelial cells (Konsoula and Barile, 2005;Shah et al, 2004;Rhoads et al, 2010). Consequently, we could conclude that the MeTIO derivative is highly toxic to the intestinal epithelium, which would invalidate its use as a drug.…”

Section: Substancementioning

confidence: 99%

Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against Methicillin-resistant Staphylococcus aureus (MRSA)

Fernandes

Gonçalves

Scotti

et al. 2012

Toxicology in Vitro

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Cytotoxicity of nanostructured vanadium oxide on human cells in vitro

Cited by 30 publications

References 22 publications

Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps

Nanoparticle toxicity by the gastrointestinal route: evidence and knowledge gaps

Cyclodextrin modulates the cytotoxic effects of chlorhexidine on microrganisms and cellsin vitro

Caco-2 cells cytotoxicity of nifuroxazide derivatives with potential activity against Methicillin-resistant Staphylococcus aureus (MRSA)

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