2007
DOI: 10.1148/radiol.2422060245
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Cytotoxicity of Iodinated and Gadolinium-based Contrast Agents in Renal Tubular Cells at Angiographic Concentrations: In Vitro Study

Abstract: At angiographic concentrations, gadolinium-based contrast agents do not induce fewer cytotoxic effects on cultured renal tubular cells than does iomeprol.

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Cited by 89 publications
(75 citation statements)
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“…10,[26][27][28][29][30] The findings from the trypan blue exclusion assay indicate that cell death can in part be explained by the osmolality of the ICM, as this increases with increasing osmolality, supported by regression analysis which showed a reasonably good correlation between the two (r 2 = 0.76). However, the three non-ionic monomers differ in their potential to induce cell death.…”
Section: Discussionmentioning
confidence: 88%
“…10,[26][27][28][29][30] The findings from the trypan blue exclusion assay indicate that cell death can in part be explained by the osmolality of the ICM, as this increases with increasing osmolality, supported by regression analysis which showed a reasonably good correlation between the two (r 2 = 0.76). However, the three non-ionic monomers differ in their potential to induce cell death.…”
Section: Discussionmentioning
confidence: 88%
“…Rats were housed at [23][24][25] C in a 12-h light/dark cycle with free access to standard rat chow and tap water. All animal experiments were performed with the permission from the Medical Ethics Committee of Tianjin Medical University and followed the protocol outlined in the Guide for the Care and Use of Laboratory Animals published by the US National Institutes of Health (NIH Publication No.…”
Section: Animalsmentioning
confidence: 99%
“…For example, when cultured renal tubular cells were incubated with Gd-CM and I-CM, the degree of cytotoxicity was similar. 17 Nyman et al 19 report a significantly more pronounced decrease in GFR in animals given Gd-CM than in those given I-CM.…”
Section: Discussionmentioning
confidence: 98%
“…15 In fact, histological data from a few animal studies suggest that Gd-CM induces acute tubular necrosis and cytoplasmic vacuolization in renal tubular cells in several hours. [16][17][18] For the above reasons, we further used a less stringent criterion (a decrease >10% in GFR) for AKI. This may explain why we found a higher incidence of AKI after administration of Gd-CM at the doses for MRI and MRA examinations.…”
Section: Discussionmentioning
confidence: 99%