Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells

Kuete, Victor; Voukeng, Igor K.; Roger, Tsobou; Mbaveng, Armelle T.; Wiench, Benjamin; Beng, Véronique Penlap; Efferth, Thomas

doi:10.1186/1472-6882-13-250

Cited by 30 publications

(15 citation statements)

References 47 publications

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“…The concentration needed to reduce the growth of the Jurkat T cells to 50% was 19 μ g·mL −1 . This concentration is considered to be very low, as, according to the American National Cancer Institute, a value of 30 μ g·mL −1 is the highest IC 50 that is considered promising when searching for activity in whole extracts [ 11 ]. The extract may contain phytochemicals that have potential anticancer properties.…”

Section: Discussionmentioning

confidence: 99%

“…A variety of compounds can be used as starting points for the synthesis of new drugs with improved activity [ 10 ]. Between 1983 and 1994, 60% of approved anticancer drugs were from natural sources [ 11 ]. A water extract of green tea leaves was recently approved for use as a drug by the Food and Drug Administration (FDA), proving that plant products can meet the high standards required by the FDA [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Antiproliferative Activity ofT. welwitschiiExtract on Jurkat T CellsIn Vitro

Moyo

Mukanganyama

2015

BioMed Research International

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Triumfetta welwitschii is a plant used traditionally for the treatment of fever and diarrhoea. Previous work has shown that T. welwitschii has antibacterial activity. The purpose of this study was to investigate T. welwitschii extract for anticancer activity against Jurkat T cells. The Jurkat T cell line is used to study acute T cell leukaemia. An antiproliferation assay, determination of induction of apoptosis, the determination of the effect of the combination of the extract and GSH, and effects of the extract on DNA leakage were conducted. T. welwitschii was found to decrease cell viability in a dose- and time-dependent manner. T. welwitschii caused apoptosis in the Jurkat T cells as shown by DNA fragmentation. When T. welwitschii was combined with reduced GSH, it was found that the growth of the Jurkat T cells was significantly reduced compared to untreated cells after 72 h of treatment. This was unexpected, as cancer cells have elevated levels of GSH compared to normal cells. The results of this study show that T. welwitschii is a potential source of compounds that may serve as leads for anticancer compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiproliferative Activity ofT. welwitschiiExtract on Jurkat T CellsIn Vitro

Moyo

Mukanganyama

2015

BioMed Research International

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“…(Mimosaceae), Eremomastax speciosa (Hochst) Cufod (Acanthaceae), and Piliostigma thonningii (Schum.) Milne-Redhead (Caesalpiniaceae) harvested in Cameroon were also investigated for their antiproliferative effects towards a panel of drug-sensitive and -resistant cancer cell lines ( Table 1 ) [ 42 ]. The best activity was recorded with Elaoephorbia drupifera , which demonstrated a strong inhibitory effect on nine of nine tested cancer cell lines with other plants showing selective activities.…”

Section: Antiproliferative Effects Of African Plants Towards Mdr Cmentioning

confidence: 99%

“…0.62 compared to MDA-MB-231 cells) was observed towards Crinum zeylanicum extract and that of the resistant U87MG.Δ EGFR cells (D.R. 0.0.68 compared to U87MG cells) [ 42 ]. A panel of Egyptian medicinal plants was recently screened for their cytotoxic potential against four cell lines, namely, human pancreatic cancer MiaPaCa-2 cells, breast cancer MCF-7 cells, leukemia CCRF-CEM cells, and their multidrug-resistant subline CEM/ADR5000 cells [ 43 ].…”

Section: Antiproliferative Effects Of African Plants Towards Mdr Cmentioning

confidence: 99%

African Flora Has the Potential to Fight Multidrug Resistance of Cancer

Kuete

Efferth

2015

BioMed Research International

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162

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Background. Continuous efforts from scientists of diverse fields are necessary not only to better understand the mechanism by which multidrug-resistant (MDR) cancer cells occur, but also to boost the discovery of new cytotoxic compounds to fight MDR phenotypes. Objectives. The present review reports on the contribution of African flora in the discovery of potential cytotoxic phytochemicals against MDR cancer cells. Methodology. Scientific databases such as PubMed, ScienceDirect, Scopus, Google Scholar, and Web of Knowledge were used to retrieve publications related to African plants, isolated compounds, and drug resistant cancer cells. The data were analyzed to highlight cytotoxicity and the modes of actions of extracts and compounds of the most prominent African plants. Also, thresholds and cutoff points for the cytotoxicity and modes of action of phytochemicals have been provided. Results. Most published data related to the antiproliferative potential of African medicinal plants were from Cameroon, Egypt, Nigeria, or Madagascar. The cytotoxicity of phenolic compounds isolated in African plants was generally much better documented than that of terpenoids and alkaloids. Conclusion. African flora represents an enormous resource for novel cytotoxic compounds. To unravel the full potential, efforts should be strengthened throughout the continent, to meet the challenge of a successful fight against MDR cancers.

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“…It is a polymorphous herb that grows up to 2 m high with remarkable quadrangular stem (Amang et al, 2014). The leaf (decoction or infusion or maceration) is used by the natives in the treatment of dysentery, anaemia, menstrual pain, fracture, hemorrhoids and urinary tract infection (Iba et al, 2015;Oben et al, 2006;Kuete et al, 2013). The aerial part of the plant has been reported in scientific literature to possess antianaemic, antiulcer, antisecretory, antimicrobial, antifungal and antidiarrheal activities (Amang et al, 2014;Iba et al, 2015;Oben et al, 2006;Okokon et al, 2007;Mouokeu et al, 2015;Tan et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Anti-Nociceptive Properties of Hydro-Methanol Extract of Eremomastax Speciosa (Hochst.) Cufod Leaf

Onoja¹,

Eke²,

Ejiofo³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Eremomastax speciosa (Hochst.) Cufod is a perennial herb found in Africa along the rainforest zone and occurs as weed. It is cultivated in Cameroon and Akwa-Ibom in Nigeria due to its medicinal values. This study investigated the antioxidant, anti-inflammatory and antinociceptive properties of hydromethanol extract of Eremomastax speciosa (Hochst.) Cufod leaf in rat model. Materials and Methods: The plant material was extracted using cold maceration method in 80% hydromethanol. The acute oral toxicity test was performed using Up and Down method with limit dose of 2000 mg/kg. The in vitro antioxidant property was evaluated with 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power photometric assays. The anti-inflammatory potential was investigated in egg-albumin and carrageenan induced paw edema models while the antinociceptive activity was determined using acetic acid induced writhing reflex and tail immersion tests at the doses of 50, 100 and 200 mg/kg. The negative control group (group A) received distilled water (vehicle) at 5 ml/kg while acetyl salicylic acid (200 mg/kg) was used as the reference drug for the anti-inflammatory models and acetic acid induced writhing reflex model while pentazocine (5 mg/kg) was used as the reference drug for tail immersion test. Results: The LD 50 of the extract was greater than 2000 mg/kg. The extract (25 to 400 µg/ml) demonstrated potent antioxidant activities in both the 2,2-diphenyl-1-picrylhydrazyl and ferric reducing antioxidant power assays. The E. speciosa extract caused significant (P < 0.05) anti-inflammatory and antinociceptive activities in the extract treated groups when compared to rats that received distilled water. The optimal activities of the extract were produced at the dose of 100 mg/kg. Conclusion: The study supports the folkloric use of Eremomastax speciosa leaf in the management of pain and inflammatory conditions in traditional medicine.

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Cytotoxicity of Elaoephorbia drupifera and other Cameroonian medicinal plants against drug sensitive and multidrug resistant cancer cells

Cited by 30 publications

References 47 publications

Antiproliferative Activity ofT. welwitschiiExtract on Jurkat T CellsIn Vitro

Antiproliferative Activity ofT. welwitschiiExtract on Jurkat T CellsIn Vitro

African Flora Has the Potential to Fight Multidrug Resistance of Cancer

Antioxidant, Anti-Inflammatory and Anti-Nociceptive Properties of Hydro-Methanol Extract of Eremomastax Speciosa (Hochst.) Cufod Leaf

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