Cytotoxicity of corrosion products of degradable Fe-based stents: Relevance of pH and insoluble products

Fagali, Natalia; Grillo, Claudia Alejandra; Puntarulo, Susana; Mele, Mónica Alicia Fernández Lorenzo de

doi:10.1016/j.colsurfb.2015.02.047

Cited by 34 publications

(20 citation statements)

References 33 publications

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“…Biocompatibility of the bare Fe and nano Ta–Fe samples was confirmed by both in vitro cellular response and in vivo animal tests. Although Fe participates in a wide variety of metabolic processes in the body, when the number of released Fe ions from the implant exceeds the tolerable limit for uptake by intracellular elements, cells inevitably suffer various degree of cytotoxicity, and severe immunogenic responses can be triggered, thus limiting the efficacy and biosafety of Fe [ 44 , 45 ]. In fact, as illustrated in Fig.…”

Section: Discussionmentioning

confidence: 99%

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Lee

Park

et al. 2022

Bioactive Materials

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In recent years, pure iron (Fe) has attracted significant attention as a promising biodegradable orthopedic implant material due to its excellent mechanical and biological properties. However, in physiological conditions, Fe has an extremely slow degradation rate with localized and irregular degradation, which is problematic for practical applications. In this study, we developed a novel combination of a nanostructured surface topography and galvanic reaction to achieve uniform and accelerated degradation of an Fe implant. The target-ion induced plasma sputtering (TIPS) technique was applied on the Fe implant to introduce biologically compatible and electrochemically noble tantalum (Ta) onto its surface and develop surface nano-galvanic couples. Electrochemical tests revealed that the uniformly distributed nano-galvanic corrosion cells of the TIPS-treated sample (nano Ta–Fe) led to relatively uniform and accelerated surface degradation compared to that of bare Fe. Furthermore, the mechanical properties of nano Ta–Fe remained almost constant during a long-term in vitro immersion test (~40 weeks). Biocompatibility was also assessed on surfaces of bare Fe and nano Ta–Fe using in vitro osteoblast responses through direct and indirect contact assays and an in vivo rabbit femur medullary cavity implantation model. The results revealed that nano Ta–Fe not only enhanced cell adhesion and spreading on its surface, but also exhibited no signs of cellular or tissue toxicity. These results demonstrate the immense potential of Ta-implanted surface nanostructures as an effective solution for the practical application of Fe-based orthopedic implants, ensuring long-term biosafety and clinical efficacy.

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Section: Discussionmentioning

confidence: 99%

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Lee

Park

et al. 2022

Bioactive Materials

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“…In the last decades, the paradigm establishing that implants must be inert and corrosion resistant has been displaced by the advent of a new class of metallic biomaterials: biodegradable metallic materials [ 1 ]. Compared with other materials, these metals have high impact strength, high wear resistance, high ductility, and toughness [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Pogorielov

Husak

Solodivnik

et al. 2017

Interventional Medicine and Applied Science

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In recent years, the paradigm about the metal with improved corrosion resistance for application in surgery and orthopedy was broken. The new class of biodegradable metal emerges as an alternative for biomedical implants. These metals corrode gradually with an appropriate host response and release of corrosion products. And it is absolutely necessary to use essential metals metabolized by hosting organism with local and general nontoxic effect. Magnesium serves this aim best; it plays the essential role in body metabolism and should be completely excreted within a few days after degradation. This review summarizes data from Mg discovery and its first experimental and clinical application of modern concept of Mg alloy development. We focused on biodegradable metal application in general surgery and orthopedic practice and showed the advantages and disadvantages Mg alloys offer. We focused on methods of in vitro and in vivo investigation of degradable Mg alloys and correlation between these methods. Based on the observed data, a better way for new alloy pre-clinical investigation is suggested. This review analyzes possible alloying elements that improve corrosion rate, mechanical properties, and gives the appropriate host response.

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“…Additionally, Liu et al detected no adverse effects when various alloying elements (Mn, Co, Al, W, B, C, and S) were added 14,15 . Fagali et al showed that the mitochondrial activity and pH-value depend on Fe 3+ activity 16 . In vivo experiments showed that the implanted iron or tungsten stents were predominantly absorbed and did not lead to any distinct inflammatory reaction and elevated serum ion levels in blood analysis 17,18 .…”

mentioning

confidence: 99%

Development of a novel biodegradable porous iron-based implant for bone replacement

Wegener

Sichler

Milz

et al. 2020

Sci Rep

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Bone replacement and osteosynthesis require materials which can at least temporarily bear high mechanical loads. ideally, these materials would eventually degrade and would be replaced by bone deposited from the host organism. to date several metals, notably iron and iron-based alloys have been identified as suitable materials because they combine high strength at medium corrosion rates. However, currently, these materials do not degrade within an appropriate amount of time. therefore, the aim of the present study is the development of an iron-based degradable sponge-like (i.e. cellular) implant for bone replacement with biomechanically tailored properties. We used a metal powder sintering approach to manufacture a cylindrical cellular implant which in addition contains phosphor as an alloying element. No corrosion inhibiting effects of phosphorus have been found, the degradation rate was not altered. implant prototypes were tested in an animal model. Bone reaction was investigated at the bone-implant-interface and inside the cellular spaces of the implant. newly formed bone was growing into the cellular spaces of the implant after 12 months. Signs of implant degradation were detected but after 12 months, no complete degradation could be observed. In conclusion, ironbased open-porous cellular biomaterials seem promising candidates for the development of selfdegrading and high load bearing bone replacement materials.

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Cytotoxicity of corrosion products of degradable Fe-based stents: Relevance of pH and insoluble products

Cited by 34 publications

References 33 publications

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Accelerated biodegradation of iron-based implants via tantalum-implanted surface nanostructures

Magnesium-based biodegradable alloys: Degradation, application, and alloying elements

Development of a novel biodegradable porous iron-based implant for bone replacement

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