2016
DOI: 10.1590/1519-6984.20514
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Cytotoxicity of Cheese and Cheddar Cheese food flavorings on Allim cepa L root meristems

Abstract: Despite their great importance for the food industry, flavorings, in general, raise a number of questions regarding their cytotoxicity, mutagenicity and carcinogenicity, since, in the literature, there are few studies found evaluating the toxicity on the systemic and cellular level, of these chemical compounds. The root meristems of Allium cepa (onion) are widely used for the assessment of toxicity of chemical compounds of interest. Thus, this study aimed to evaluate, in A. cepa meristematic cells, individuall… Show more

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Cited by 20 publications
(33 citation statements)
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“…According to Caritá & Marin-Morales (2008), mitotic index lower than that of the negative control indicates the presence of agents whose toxic action affects the growth and development of exposed organisms. Complementing these authors, Gomes et al (2013), Marques et al (2015), and Moura et al (2016) claim that the inhibition of cell proliferation triggered by cytotoxic compounds in tissue with intense cell proliferation and with normal performance or without cellular changes, such as those used in this study for assessment of UHT milk toxicity, is quite harmful to the organism, since it possesses the property of inhibiting or limiting the replenishment of cells, altering the production of proteins and resulting in malfunction of the organ where it is located (Gomes et al, 2013;Marques et al, 2015;Moura et al, 2016).…”
Section: Resultsmentioning
confidence: 85%
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“…According to Caritá & Marin-Morales (2008), mitotic index lower than that of the negative control indicates the presence of agents whose toxic action affects the growth and development of exposed organisms. Complementing these authors, Gomes et al (2013), Marques et al (2015), and Moura et al (2016) claim that the inhibition of cell proliferation triggered by cytotoxic compounds in tissue with intense cell proliferation and with normal performance or without cellular changes, such as those used in this study for assessment of UHT milk toxicity, is quite harmful to the organism, since it possesses the property of inhibiting or limiting the replenishment of cells, altering the production of proteins and resulting in malfunction of the organ where it is located (Gomes et al, 2013;Marques et al, 2015;Moura et al, 2016).…”
Section: Resultsmentioning
confidence: 85%
“…This test system is internationally accepted by research agencies as an assessment tool with accurate sensitivity for analysis of cytotoxicity, genotoxicity and mutagenicity of the substance of interest, since the results obtained mostly show satisfactory similarity to those obtained via animal testing systems and cell cultures (Herrero et al, 2012;Lacerda et al, 2014;Tabrez et al, 2011;Gomes et al, 2013;Dliveira et al, 2013;Campos-Ventura et al, 2016;Moura et al, 2016;Santana et al, 2016;Bezerra et al, 2016;Nunes et al, 2016).…”
Section: Introductionmentioning
confidence: 99%
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“…Globalization and the development of new technologies have caused significant changes in the eating habits of the population, which, in recent decades, has gradually introduced foods rich in chemical additives into the everyday life (Gomes et al, 2013;Moura et al, 2016). Among these substances, also called microingredients, are the flavorings, essential for the food industry for conferring specific sensory properties of taste and smell to processed foods (Xu et al, 2015;Marques et al, 2015).…”
Section: Introductionmentioning
confidence: 99%