Cytotoxicity of a metal–organic framework: Drug delivery

Ma, Aiqing; Luo, Zhidong; Gu, Chuying; Liu, Baohong; Liu, Jianqiang

doi:10.1016/j.inoche.2017.01.004

Cited by 27 publications

(5 citation statements)

References 24 publications

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“…Metal organic frameworks (MOFs) are crystalline porous materials with ultrahigh surface areas,1–3 consisting of metal ions or clusters linked with organic ligands via coordination bonds 4–6. The large number of combinations of metal ions and organic ligands available during such material synthesis confers a high degree of tunability of MOF's geometry, size, porosity and functionality, respectively 5,6. Such features conversely elicit MOF integration in numerous applications ranging from gas capture and storage7,8 to water adsorption and from catalysis to electrical-based applications 9–12…”

Section: Introductionmentioning

confidence: 99%

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Wagner

Liu

Rose

et al. 2019

IJN

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IntroductionThe flexibility and tunability of metal organic frameworks (MOFs), crystalline porous materials composed of a network of metal ions coordinated by organic ligands, confer their variety of applications as drug delivery systems or as sensing and imaging agents. However, such properties also add to the difficulty in ensuring their safe implementation when interaction with biological systems is considered.MethodsIn the current study, we used real-time sensorial strategies and cellular-based approaches to allow for fast and effective screening of two MOFs of prevalent use, namely, MIL-160 representative of a hydrophilic and ZIF-8 representative of a hydrophobic framework. The two MOFs were synthesized “in house” and exposed to human bronchial epithelial (BEAS-2B) cells, a pertinent toxicological screening model.ResultsAnalysis allowed evaluation and differentiation of particle-induced cellular effects as well identification of different degrees and routes of toxicity, all in a high-throughput manner. Our results show the importance of performing screening toxicity assessments before introducing MOFs to biomedical applications.DiscussionOur proposed screening assays could be extended to a wider variety of cell lines to allow for identification of any deleterious effects of MOFs, with the range of toxic mechanisms to be differentiated based on cell viability, morphology and cell–substrate interactions, respectively.ConclusionOur analysis highlights the importance of considering the physicochemical properties of MOFs when recommending a MOF-based therapeutic option or MOFs implementation in biomedical applications.

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Section: Introductionmentioning

confidence: 99%

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Wagner

Liu

Rose

et al. 2019

IJN

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“…72 Moreover, the potential presence of impurities or residual reactants from the synthesis process can contribute to the observed cytotoxicity. 73,74 The cytotoxicity mechanisms of MXenes are still not fully understood and require further investigation. Some studies have suggested that MXenes can induce oxidative stress in cells, leading to cytotoxic effects.…”

Section: Environmental Implications In Biomedical Applications Of Mxe...mentioning

confidence: 99%

Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

Farasati Far,

Rabiee,

Iravani

2023

RSC Adv.

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“…[ 91 ] The cytotoxicity of Zn‐based GDMU‐4 was also evaluated and the safe concentration was below 20 μg mL −1 . [ 92 ] Ren's group found that Zn‐based IRMOF‐3 increased cell death from 100 μg mL −1 , but IRMOF‐3 inhibits macrophage activation at 25 μg mL −1 . [ 93 ] These results indicate that the threshold concentration for the cytotoxicity of Zn‐based MOFs is about 30 μg mL −1 .…”

Section: Key Factors Affecting the Cytotoxicity Of Mofsmentioning

confidence: 99%

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

Fang

Yan

2022

Small Science

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Reticular chemistry has become a powerful tool for scientists to design crystalline porous materials with different fundamental units. [1] Over the past decades, porous materials have gained great attention due to their outstanding performance and wide applications. Among various porous materials, the combination of metal nodes and organic linkers by coordination bonds creates new hybrid porous materials called metal-organic frameworks (MOFs) and opens a new window in the design of porous materials.Since the first report on MOFs by Yaghi's group in 1995, [2] more than 100 000 kinds of MOFs have been synthesized according to the Cambridge Structural Database (CSD). The unique characteristics, including tunable porosity, customized chemical composition, large specific surface area, and easy functionalization, make MOFs promising candidates for numerous applications in diverse fields such as gas storage and separation, catalysis, sensing, adsorption, energy, and biomedical sciences. [3] In addition, the large-scale production and commercialization of MOFs began from 2016. [4] For instance, the commercial MOF adsorbent for storage of 1-methylcyclopropene to ripen vegetables and fruits was driven to the market. [5] The Numat's ION-X gas cylinder was designed based on the MOF adsorbent to store hazardous gases for semiconductor industry, showing significant advantages over traditional adsorbents. [3a] Apart from the commercialization in gas storage, the MOF-303-based apparatus has been used to collect water in the desert. [6] Despite the advantages of MOFs, the wide application of MOFs has led to environmental health risks. The accidental release of MOF particles into the environment from their bulk-products is inevitable during the lifecycle of MOFs. The deposition, decomposition, and distribution of released MOFs in environmental media could result in the exposure to humans and other organisms, inducing various biological effects. In addition, the intentional administration of MOFs in biomedicine (such as bioimaging, drug delivery system) also leads to the exposure risks to humans. Under these circumstances, the environmental health risks of MOFs are unavoidable.The toxicity of MOFs plays an important role in their health risk assessment. Compared with in vivo and ex vivo toxicity assessments, in vitro toxicity evaluation based on cell culture is low cost, fast, and high throughput, making it an ideal model in toxicity research. As the basic unit in organism, cells play an important role in life activity. The toxic effects on cells would affect their function and therefore induce significant response

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Cytotoxicity of a metal–organic framework: Drug delivery

Cited by 27 publications

References 24 publications

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

<p>Toxicity screening of two prevalent metal organic frameworks for therapeutic use in human lung epithelial cells</p>

Environmental implications of metal–organic frameworks and MXenes in biomedical applications: a perspective

Recent Advances in Research on the Effect of Physicochemical Properties on the Cytotoxicity of Metal–Organic Frameworks

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