Cytotoxicity of 6,16-Disubstituted analogues of (−)-Vincadifformine

Lewin, Guy; Hocquemiller, Reynald; Schaeffer, Corinne; Lambert, Pierre‐Herve; Léonce, Stéphane

doi:10.1016/s0960-894x(01)00757-0

Cited by 6 publications

(1 citation statement)

References 9 publications

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“…The results showed that the tetracyclic alkaloids possessing a free ethyl chain such aspidospermine were more active (IC ranged 3.2 -15.4 µM) than the 50 pentacyclic alkaloids with ethyl chain included in a tetrahydrofuran such haplocine (IC ranged 22.6 -52.6 µM). The 50 cytotoxicity of aspidospermane indole alkaloids including vincadifformine have also reported by Lewin (1995) and Lewin et al (2002). The cytotoxicity of these compounds varied depending on their structures.…”

Section: Assay For Cytotoxicitysupporting

confidence: 52%

In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives

Mustofa

Mallié²,

Valentin³

et al. 2015

Indones. J. Biotechnol.

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An indole alkaloid with aspidospemane structure possessing a potential antiplasmodial activity, vincadifformine, has been isolated from Aspidosperma pyrifolium Mart. Moreover, 10 derivatives were prepared from the vincadifformine. The study was conducted to evaluate the in vitro antiplasmodial and cytotoxic activity of the vincadifformine and their semisynthetic derivatives. The in vitro antiplasmodial activity was evaluated on Plasmodium falciparum chloroquine-resistant (FcM ) and -sensitive (Nigerian) strains after 24-h and 72-h incubation, the CI of two compounds were also lower after 24-h incubation (CI, 2.0 and 4.8) than that of after 72-h incubation (CI, 9.5 and 11.5). Further study will be conducted to evaluate quantitative structure-activity relationship (QSAR) in order to design new antimalarial drugs.

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Section: Assay For Cytotoxicitysupporting

confidence: 52%

In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives

Mustofa

Mallié²,

Valentin³

et al. 2015

Indones. J. Biotechnol.

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Asymmetric Total Synthesis of Vincadifformine Enabled by a Thiourea‐Phosphonium Salt Catalyzed Mannich‐Type Reaction

Pan

Zheng

Fang

et al. 2019

Chemistry A European J

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An asymmetric total synthesis of vincadifformine is described. The limited tactics with chiral cation‐directed catalysis in total synthesis inspired the development of our strategy for accessing this alkaloid in enantionrich form. The route features a thiourea–phosphonium salt catalyzed Mannich‐type reaction, a phosphine‐promoted aza‐Morita–Baylis–Hillman reaction and a trifluoroacetic acid promoted deprotection/amidation cascade process.

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ChemInform Abstract: Cytotoxicity of 6,16‐Disubstituted Analogues of (‐)‐Vincadifformine.

et al. 2002

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Cytotoxicity of 6,16-Disubstituted analogues of (−)-Vincadifformine

Cited by 6 publications

References 9 publications

In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives

In vitro Antiplasmodial Activity and Cytotoxicity of Vincadifformine and Its Semisynthetic Derivatives

Asymmetric Total Synthesis of Vincadifformine Enabled by a Thiourea‐Phosphonium Salt Catalyzed Mannich‐Type Reaction

ChemInform Abstract: Cytotoxicity of 6,16‐Disubstituted Analogues of (‐)‐Vincadifformine.

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