Cytotoxicity, immunomodulatory, and anti-inflammatory activity of FMB extract (Fused, Micronized and Bio-activated) and its standardized extract: A comparative evaluation

Abstract

Curcuma longa (Turmeric) has been utilized for centuries in the Ayurvedic system of medicine for the treatment of various diseases and disorders. In the present study, essential trace elements (ETEs) fused in standardized extract of curcumin by utilizing an advanced technology called FMB [(fusion (F), micronization (M), bio-activation (B)] was investigated for its cytotoxicity, immunomodulatory and anti-inflammatory activities against the conventional standardized extrcat. Results of the elemental analysis showed that FMB technology significantly replenishes Iron and Zinc in the standardized extract. Cytotoxicity results revealed no toxic effect in the tested concentration. In vitro immunomodulatory activity showed that FMB extract of Curcuma longa significantly stimulates the spleen cell proliferation as compared to standardized extract and almost similar results were found in pinocytic activation. In addition, anti-inflammatory results showed that FMB extracts remarkably reverse the level of TNF-α as compared to standardized extract. Summarily, overall results showed FMB extract is more beneficial than standardized extract. Hence, we can conclude that FMB technique can be used as an effective method and approach to enhance the therapeutic efficacy of herbal medicines especially extracts.