Cytotoxicity evaluation of<i>Curcuma zedoaria</i>(Christm.) Roscoe fluid extract used in oral hygiene products

Fernandes, João Paulo S.; Mello‐Moura, Anna Carolina Volpi; Marques, Márcia Martins; Nicoletti, María Aparecida

doi:10.3109/00016357.2011.645060

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Looking for antiproliferative drugs with less toxicity toward normal cells seems especially necessary. Previous studies demonstrated that Curcuma zedoaria , as an anticancer drug, has demonstrated to have less negative effects on normal cells, 8 –10 showing that fibroblasts of human mucus lineage maintained stable cell viability from 0 hours to 7 days, when treated with Curcuma zedoaria extract. In the present study, we found that ZGS, bioactive substances extracted from Curcuma zedoaria, increased the viability rates of HUVECs and significantly reduced the suppression of HUVECs cycle at the G0/G1 phase in comparison with sirolimus.…”

Section: Discussionmentioning

confidence: 98%

“…Curcuma zedoaria , a Chinese medicinal herb, has been used to treat cancers for more than 100 years, including gastric cancer, 5 hepatoma, 6 and uterine cervical cancer, 7 while it has low toxicity on normal cells, such as human umbilical vein endothelial cells (HUVECs), 8 gastric epithelial cells, 9 and fibroblasts of human mucus lineage. 10 Moreover, Curcuma zedoaria has been demonstrated to prevent inflammation, 11,12 oxidant, 13 and hepatic injury activities. 14 Zedoary guaiane-type sesquiterpenoids (ZGS) are bioactive constituents of Curcuma zedoaria .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Zedoary Guaiane-Type Sesquiterpenes-Eluting Stents Accelerate Endothelial Healing Without Neointimal Hyperplasia in a Porcine Coronary Artery Model

Cui

Zhao

Liu

et al. 2017

J Cardiovasc Pharmacol Ther

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Zedoary Guaiane-Type Sesquiterpenes-Eluting Stents Accelerate Endothelial Healing Without Neointimal Hyperplasia in a Porcine Coronary Artery Model

Cui

Zhao

Liu

et al. 2017

J Cardiovasc Pharmacol Ther

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“…Many in vitro tests such as MTT, trypan blue exclusion test, micronucleus are used to determine cell viability. [27,28,41,42,43,44,45,46]. Flow cytometry analysis is frequently recommended in terms of providing more reliable, faster and more sensitive results than other methods in evaluating cell viability and cytotoxicity [47].…”

Section: Discussionmentioning

confidence: 99%

In Vitro Investigation of the Cytotoxic Effects of Different Detergent-Containing Children's Toothpastes on Human Gingival Epithelial Cells

Birant

Duran

Akkoç

et al. 2021

Preprint

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Background: This study aimed to evaluate possible cytotoxic effects to gingival epithelial cells exposed to children toothpastes containing different detergent. Methods: Tissues required fort he isolation of human gingival epithelial cells were obtained by biopsy during the extraction of the impacted third molar tooth. Toothpaste solutions of different concentrations were prepared from five different children’s toothpastes with different detergent contents. Isolated gingival epithelial cells were stimulated with experimental groups consisting of toothpaste solutions (Colgate, Sensodyne, Splat, Nenedent, Perlodent) at different concentrations and a control group consissting of complete Dulbocco’s modified eagle medium. After the experiments, cell viability was evaluated using flow cytometry. Data analysis were done using One Way ANOVA test and Tukey post-hoc test. Results: In all experimental groups, there was a decrease in live cell rates and an increase in dead cell rates due to increased concentration. The statistically highest live cell ratios were detected in Splat’s toothpaste solutions after the control group and the group with the lowest viability values was determined in Colgate group (p<0.05). Conclusions: According to the results of the study, it was observed that toothpastes containing SLS affected the viability of cells more negatively than toothpastes with other detergent contents.

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“…menunjukkan bahwa Curcuma zedoaria bersifat biokompatibel dan aman digunakan sebagai produk oral. 10 Aktivitas antimikroba dari ekstrak kunyit putih telah diteliti dan menunjukkan adanya efek terhadap bakteri Gram positif, Gram negatif, dan fungi dengan diameter zona hambat 7-15 mm. 11 11Aktivitas antibakteri kunyit putih juga diteliti oleh Shahriar yang menunjukkan bahwa ekstrak Curcuma zedoaria menunjukan aktivitas yang signifikan terhadap beberapa bakteri Gram negatif yang diuji seperti Escherichia coli, Shigella boydii, dan Salmonella typhi dengan diameter zona hambat yang paling besar pada bakteri E. coli, yaitu sebesar 18 mm.…”

Section: Fernandesunclassified

Perbandingan Aktivitas Antibakteri Ekstrak Curcuma zedoaria dan Bahan Irigasi Natrium Hipoklorit 2.5% terhadap Enterococcus faecalis

Mozartha

Silvia

Sujatmiko

2019

JMKG

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Sodium hypochlorite (NaOCl) is a powerful disinfectant used in root canal therapy, yet it has some disadvantages. There are growing interests of using extracts of natural materials containing antibacterial secondary metabolite compounds as an alternative of irrigation solution. Aim, to compare the antibacterial activity of white turmeric extracts and 2,5% sodium hypochlorite irrigant against Enterococcus faecalis. Methods, this was a quasi experimental study. White turmeric extracts at the concentrations of 75%, 50%, 25% and 10% were used as experimental groups, while 2,5% NaOCl and distilled water were the control groups. Suspensions of Enterococcus faecalis were prepared to a 0.5 Mc Farland standard and applied onto petri plates containing Muller Hinton Agar. Six wells were created in each plate, and filled with 20 mL of the test solution. Plates were incubated at 37 ° C for 24 hours. The antibacterial activity was evaluated by measuring the clear zone around the well. Data were analyzed by Kruskall Wallis and continued by Mann U Whitney. Results, the largest growth inhibition zones were produced when the test bacteria were in contact with 2,5% NaOCl (15,0233 mm). White turmeric extract 75% concentration had weak antibacterial effect, while white turmeric extract 50%, 25%, 10% concentration, and distilled water did not has antibacterial properties against Enterococcus faecalis. Conclusion, white turmeric extract 75% concentration can inhibit the growth of Enterococcus faecalis with weak antibacterial activity.

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Cytotoxicity evaluation ofCurcuma zedoaria(Christm.) Roscoe fluid extract used in oral hygiene products

Abstract: According to the results, the zedoary fluid extract presents low cytotoxicity and probably can be used in the oral hygiene products.

Cited by 8 publications

References 17 publications

Zedoary Guaiane-Type Sesquiterpenes-Eluting Stents Accelerate Endothelial Healing Without Neointimal Hyperplasia in a Porcine Coronary Artery Model

Zedoary Guaiane-Type Sesquiterpenes-Eluting Stents Accelerate Endothelial Healing Without Neointimal Hyperplasia in a Porcine Coronary Artery Model

In Vitro Investigation of the Cytotoxic Effects of Different Detergent-Containing Children's Toothpastes on Human Gingival Epithelial Cells

Perbandingan Aktivitas Antibakteri Ekstrak Curcuma zedoaria dan Bahan Irigasi Natrium Hipoklorit 2.5% terhadap Enterococcus faecalis

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