Cytotoxicity effects of water dispersible oxidized multiwalled carbon nanotubes on marine alga, Dunaliella tertiolecta

Wei, Liping; Thakkar, Megha; Chen, Yuhong; Ntim, Susana Addo; Mitra, Somenath; Zhang, Xueyan

doi:10.1016/j.aquatox.2010.07.001

Cited by 109 publications

(82 citation statements)

References 28 publications

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“…A study by Wei et al 52 on the marine green alga Dunaniella tertiolecta also supports this theory by showing that only large aggregates (2 μm range) of functionalized MWCNT were able to induce cytotoxic effects. Crustaceans and molluscs are well known for their ability to sequester toxic metals in granules in the hepato-pancreas and other tissues; it might therefore be possible for them to do the same with metal nanoparticles, and this would make these organisms potent bio-accumulators of this type of nanoparticles.…”

Section: Effects On Marine Organismssupporting

confidence: 55%

Potential Environmental Impact of Nanoenergetics

Perreault

2018

ECB

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Section: Effects On Marine Organismssupporting

confidence: 55%

Potential Environmental Impact of Nanoenergetics

Perreault

2018

ECB

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“…in mussel tissues and induced MT levels in mussels. [56][57][58] Recently, Neupane has developed MT-capped Cd/Se NPs, in which up to eight MTs could be attached as detected by an increase in the fluorescence intensity. 59 Cd/Se QD NP-labeled bone marrow-derived mononuclear stem cells (MNCs) have been used to determine their biodistribution, pharmacokinetics, and therapeutic potential in experimental model of AIS.…”

Section: Mts As Early and Sensitive Biomarkers Of Nps Toxicitymentioning

confidence: 99%

Clinical significance of metallothioneins in cell therapy and nanomedicine

Sharma¹,

Rais²,

Sandhu³

et al. 2013

IJN

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Mammalian metallothioneins (MTs) are low molecular weight (6-7 kDa) cysteinerich proteins that are specifically induced by metal nanoparticles (NPs). MT induction in cell therapy may provide better protection by serving as antioxidant, anti-inflammatory, antiapoptotic agents, and by augmenting zinc-mediated transcriptional regulation of genes involved in cell proliferation and differentiation. Liposome-encapsulated MT-1 promoter has been used extensively to induce growth hormone or other genes in culture and gene-manipulated animals. MTs are induced as a defensive mechanism in chronic inflammatory conditions including neurodegenerative diseases, cardiovascular diseases, cancer, and infections, hence can serve as early and sensitive biomarkers of environmental safety and effectiveness of newly developed NPs for clinical applications. Microarray analysis has indicated that MTs are significantly induced in drug resistant cancers and during radiation treatment. Nutritional stress and environmental toxins (eg, kainic acid and domoic acid) induce MTs and aggregation of multilamellar electron-dense membrane stacks (Charnoly body) due to mitochondrial degeneration. MTs enhance mitochondrial bioenergetics of reduced nicotinamide adenine dinucleotide-ubiquinone oxidoreductase (complex-1), a rate-limiting enzyme complex involved in the oxidative phosphorylation. Monoamine oxidase-B inhibitors (eg, selegiline) inhibit α-synuclein nitration, implicated in Lewy body formation, and inhibit 1-methyl 4-phenylpyridinium and 3-morpholinosydnonimineinduced apoptosis in cultured human dopaminergic neurons and mesencephalic fetal stem cells. MTs as free radical scavengers inhibit Charnoly body formation and neurodegenerative α-synucleinopathies, hence Charnoly body formation and α-synuclein index may be used as early and sensitive biomarkers to assess NP effectiveness and toxicity to discover better drug delivery and surgical interventions. Furthermore, pharmacological interventions augmenting MTs may facilitate the theranostic potential of NP-labeled cells and other therapeutic agents. These unique characteristics of MTs might be helpful in the synthesis, characterization, and functionalization of emerging NPs for theranostic applications. This report highlights the clinical significance of MTs and their versatility as early, sensitive biomarkers in cell-based therapy and nanomedicine.

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“…Some researches indicate that the function of nanoparticles in organisms is mediated by reactive oxygen species (ROS) production (Nel et al, 2006;Oukarroum et al, 2012;Klaine et al, 2008;Bhattacharya et al, 2010), which can cause cell damage and lipid oxidation. Wei et al (2010) indicate that the direct contact between f-MWNT and algal cell surface (algal cell/nanoparticles aggregation) was likely responsible for reduced PSII functional cross section and oxidative stress during exponential growth. Gong et al (2011) found that there was noticeable algal cell/NiO aggregation which may cause a reduction in the light available to those cells and thus inhibiting their growth.…”

Section: Introductionmentioning

confidence: 99%