Cytotoxicity characteristics of green assisted-synthesized superparamagnetic maghemite (γ-Fe2O3) nanoparticles

Kianvash, A.; Hajalilou, Abdollah; Abouzari‐Lotf, Ebrahim; Zarebkohan, Amir

doi:10.1007/s10854-018-9321-8

Cited by 31 publications

(16 citation statements)

References 46 publications

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“…The nucleation of the NPs in the presence of the extract was translated into an efficient bonding between the phenolic compounds of the extract into/onto the NPs to strongly avoid deep oxidation, possibly suitable for various biomedical applications. 13 , 15 As previously reported, 64 normal cells could decrease their heat-sensitivity five or six times than that of the growing situation at the conflux, but the cancer cells were unable. In this manner, cancer cells might indicate higher temperature (above 37°C) compared to normal cells (below 37°C).…”

Section: Resultsmentioning

confidence: 53%

“…1,13 Therefore, Fe 3 O 4 NPs stabilized with the plant extracts could potentially show better water permeability, antioxidant activity, biocompatibility, biodegradability, and tolerable toxicity for various biomedical applications compared to using other traditional methods. [14][15][16] Compared to the normal amount consumed with a low phenolic content, the plant extract might induce a greater amount of a metabolite compound of polyphenol or flavonoid subclass and distribute at the targeted site for stronger antioxidant and anticancer activities. 17 Polyphenols, especially anthocyanins, undergo a major structural changes during the in vitro or in vivo evaluations, improving both bioavailability and biological properties.…”

Section: Introductionmentioning

confidence: 99%

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Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Yusefi¹,

Shameli²,

Yee³

et al. 2021

IJN

108

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Introduction: Fe 3 O 4 nanoparticles (Fe 3 O 4 NPs) with multiple functionalities are intriguing candidates for various biomedical applications. Materials and Methods: This study introduced a simple and green synthesis of Fe 3 O 4 NPs using a low-cost stabilizer of plant waste extract rich in polyphenols content with a well-known antioxidant property as well as anticancer ability to eliminate colon cancer cells. Herein, Fe 3 O 4 NPs were fabricated via a facile co-precipitation method using the crude extract of Garcinia mangostana fruit peel as a green stabilizer at different weight percentages (1, 2, 5, and 10 wt.%). The samples were analyzed for magnetic hyperthermia and then in vitro cytotoxicity assay was performed. Results: The XRD planes of the samples were corresponding to the standard magnetite Fe 3 O 4 with high crystallinity. From TEM analysis, the green synthesized NPs were spherical with an average size of 13.42±1.58 nm and displayed diffraction rings of the Fe 3 O 4 phase, which was in good agreement with the obtained XRD results. FESEM images showed that the extract covered the surface of the Fe 3 O 4 NPs well. The magnetization values for the magnetite samples were ranging from 49.80 emu/g to 69.42 emu/g. FTIR analysis verified the functional groups of the extract compounds and their interactions with the NPs. Based on DLS results, the hydrodynamic sizes of the Fe 3 O 4 nanofluids were below 177 nm. Furthermore, the nanofluids indicated the zeta potential values up to −34.92±1.26 mV and remained stable during four weeks of storage, showing that the extract favorably improved the colloidal stability of the Fe 3 O 4 NPs. In the hyperthermia experiment, the magnetic nanofluids showed the acceptable specific absorption rate (SAR) values and thermosensitive performances under exposure of various alternating magnetic fields. From results of in vitro cytotoxicity assay, the killing effects of the synthesized samples against HCT116 colon cancer cells were mostly higher compared to those against CCD112 colon normal cells. Remarkably, the Fe 3 O 4 NPs containing 10 wt.% of the extract showed a lower IC 50 value (99.80 µg/mL) in HCT116 colon cancer cell line than in CCD112 colon normal cell line (140.80 µg/mL). Discussion: This research, therefore, introduced a new stabilizer of Garcinia mangostana fruit peel extract for the biosynthesis of Fe 3 O 4 NPs with desirable physiochemical properties for potential magnetic hyperthermia and colon cancer treatment.

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Section: Resultsmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Yusefi¹,

Shameli²,

Yee³

et al. 2021

IJN

108

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“…In contrast to this, in Table 3 , absorption bands are more slightly dispersed. This could be attributed to nano-γ-Fe 2 O 3 tetrahedral sites [ 127 ] that interact with TiO 2 NPs and As species. Additionally, it must be mentioned that nano-γ-Fe 2 O 3 can present remaining peaks at 800–900 cm −1 [ 128 , 129 ], so part of the residual in this range in Figure 6 and Figure 7 could be due to these infrared (IR) absorption bands.…”

Section: In-detail Discussion Of the Adsorbent Propertiesmentioning

confidence: 99%

Differentiating Nanomaghemite and Nanomagnetite and Discussing Their Importance in Arsenic and Lead Removal from Contaminated Effluents: A Critical Review

2021

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Arsenic and lead heavy metals are polluting agents still present in water bodies, including surface (lake, river) and underground waters; consequently, the development of new adsorbents is necessary to uptake these metals with high efficiency, quick and clean removal procedures. Magnetic nanoparticles, prepared with iron-oxides, are excellent candidates to achieve this goal due to their ecofriendly features, high catalytic response, specific surface area, and pulling magnetic response that favors an easy removal. In particular, nanomagnetite and maghemite are often found as the core and primary materials regarding magnetic nanoadsorbents. However, these phases show interesting distinct physical properties (especially in their surface magnetic properties) but are not often studied regarding correlations between the surface properties and adsorption applications, for instance. Thus, in this review, we summarize the main characteristics of the co-precipitation and thermal decomposition methods used to prepare the nano-iron-oxides, being the co-precipitation method most promising for scaling up processes. We specifically highlight the main differences between both nano-oxide species based on conventional techniques, such as X-ray diffraction, zero and in-field Mössbauer spectroscopy, X-ray photoelectron spectroscopy, X-ray absorption spectroscopy, and X-ray magnetic circular dichroism, the latter two techniques performed with synchrotron light. Therefore, we classify the most recent magnetic nanoadsorbents found in the literature for arsenic and lead removal, discussing in detail their advantages and limitations based on various physicochemical parameters, such as temperature, competitive and coexisting ion effects, i.e., considering the simultaneous adsorption removal (heavy metal–heavy metal competition and heavy metal–organic removal), initial concentration, magnetic adsorbent dose, adsorption mechanism based on pH and zeta potential, and real water adsorption experiments. We also discuss the regeneration/recycling properties, after-adsorption physicochemical properties, and the cost evaluation of these magnetic nanoadsorbents, which are important issues, but less discussed in the literature.

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“…The toxicity studies showed that IONPs might have a toxicity effect as a redox agent on different cell types at only concentrations above 100 µg mL −1 (Ankanwar et al ., 2010; Bali Ogholbeyg et al ., 2018). In the current study, the maximum concentration of IONPs added into the film was only12 µg mL −1 .…”

Section: Discussionmentioning

confidence: 99%

Development of nanocomposite biodegradable film containing iron nanoparticles biosynthesised by Saccharomyces cerevisiae

Al‐Hayali

Mehmetoğlu

2022

Int J of Food Sci Tech

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The use of nanoparticles in biodegradable films has been shown to improve their characteristics in food packaging. The study was designed to investigate the effect of iron oxide nanoparticles (IONPs) and lysed yeast cells residue (YSR) on the properties of whey protein concentrate (WPC) films. IONPs (0, 0.5, 1.0 and 1.5 mM) biosynthesised by Saccharomyces cerevisiae and YSR were used to prepare WPC films. The addition of IONPs and YSR increased the tensile strength (TS) of the films by approximately 2.6 MPa compared with the control films (P < 0.05). Percent elongation and water vapour permeability of the films decreased significantly (P < 0.05) by the contribution of IONPs. All the films did not inhibit the growth of tested microorganisms. The incorporation of YSR in the film also did not make a significant change in any properties of the film (P > 0.05). The results indicated the usefulness of IONPs incorporation into WPC films to enhance mechanical but not antimicrobial properties.

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Cytotoxicity characteristics of green assisted-synthesized superparamagnetic maghemite (γ-Fe2O3) nanoparticles

Cited by 31 publications

References 46 publications

Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Green Synthesis of Fe3O4 Nanoparticles Stabilized by a Garcinia mangostana Fruit Peel Extract for Hyperthermia and Anticancer Activities

Differentiating Nanomaghemite and Nanomagnetite and Discussing Their Importance in Arsenic and Lead Removal from Contaminated Effluents: A Critical Review

Development of nanocomposite biodegradable film containing iron nanoparticles biosynthesised by Saccharomyces cerevisiae

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