Cytotoxicity assessment of palbociclib-loaded chitosan-polypropylene glycol nano vehicles for cancer chemotherapy

Rajan, Mariappan; Praphakar, Rajendran Amarnath; Govindaraj, Dharman; Arulselvan, Palanisamy; Kumar, S. Suresh

doi:10.1016/j.mtchem.2017.08.002

Cited by 25 publications

(10 citation statements)

References 33 publications

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“…The extra methyl group decreases the hydrophilicity of the PPG and induces hydrophobic character [41]. PPG is a stable, non-toxic, biodegradable and biocompatible polymer that is used for the preparation of many biomaterials and other biomedical products [42]. The presence of an ether group in the chain makes it a suitable candidate for the stabilization of metal nanoparticles [43].…”

Section: Introductionmentioning

confidence: 99%

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

et al. 2021

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The development of metal nanoparticle-based facile colorimetric assays for drugs and insecticides is an emerging area of current scientific research. In the present work, polypropylene glycol was used for stabilization of gold nanoparticles (AuNPs) in a simple one-pot two-phase process and subsequently employed it for the specific detection of cephradine (CPH). The characterization of the prepared PPG-AuNPs was conducted through various analytical techniques such as UV-visible spectrophotometry, Fourier transform infrared spectroscopy, atomic force microscopy (AFM), zeta potential and zetasizer techniques. As the major target of the study, the stabilized PPG-AuNPs were employed for colorimetric detection of CPH and other drugs. Typical wine-red colour of PPG-AuNPs disappeared immediately and surface plasmon resonance band quenched by addition of CPH in the presence of several other interferents (drugs and salts) and in real samples. PPG-AuNPs permitted efficient, selective, reliable and rapid determination in a concentration range of 0.01–120 mM with a detection limit (LoD) of 11.0 mM. The developed sensor has the potential to be used for fast scanning of pharmaceutical formulations for quantification of CPH at production facilities.

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Section: Introductionmentioning

confidence: 99%

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

et al. 2021

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“…PPG has a simple structure that contains carbon, oxygen and hydrogen, and consists of a viscous, hygroscopic, and odorless fluid. Compared to PEG, PPG is less toxic, shows good solubility, high chemical stability, is biocompatible, and biodegradable [35]. Thus, PHB/PPG blends result in a polymeric material with a higher degradation temperature, which represents a gain in its mechanical properties and possibilities of usage [28,34].…”

Section: Introductionmentioning

confidence: 99%

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

et al. 2021

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Natural polymers have attracted much attention in recent years for the study of new drug delivery systems. These materials are used as polymer matrices to protect the active drug from degradation in the biological environment and to improve the release kinetics of the drug. The poly(3-hydroxybutyrate) (PHB) is a natural biocompatible polymer, widely used in combination with other polymers to improve their physicochemical properties. Thus, this work aimed to develop and characterize films of PHB and blends containing polypropylene glycol (PPG) with different concentrations of simvastatin (Simv.). The films were prepared by casting, dissolving PHB or a blend of PHB / PPG (90:10) and (5% or 25 %) Simv. in chloroform (2% w/v). The solutions were stirred for 3 h and then transferred to an appropriate glass mold for solvent evaporation for 48 h at room temperature. The obtained films were characterized by Fourier Transform Infrared (FTIR) spectroscopy, thermogravimetric analysis, scanning electron microscopy (SEM), optical microscopy, in vitro degradation study, and in vivo biocompatibility test. The results showed that PHB and blends of PHB / PPG are able to form a homogeneous film with the drug inside. A great amount of drug lead to the instability of polymeric matrixes and resulted in a facilitated film degradation. On the other hand, devices with 5% of Simv. were more stable, which suggests the application of these films for biomedical devices. In vivo studies revealed that the films can interact with the animals' organism, and do not undergo rejection. Hence, these films hold an innovative alternative in tissue engineering to promotes drug release by diffusion and erosion of the polymeric material.

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“…The spectrum of Alp ( Figure S2A ) demonstrates typical peaks at 1400–1000 cm −1 corresponding to C–F vibration, 1317 cm −1 (C–S stretching band [ 53 ]), 1640 cm −1 (carbonyl stretching band), broad peaks at 2770–2870 cm −1 (C-H and CH 3 groups), and a peak at 3500 cm −1 corresponding to N–H stretching band [ 54 ]. The spectrum of Pal ( Figure S2B ) demonstrates typical peaks at 1900–1640 cm −1 corresponding to the carbonyl stretching band, 2780–2960 cm −1 (C–H and CH 3 stretching band [ 55 ]) and 3500 cm −1 (N–H stretching band [ 54 ]). The spectrum of P(RGD) ( Figure S2C ) demonstrates typical peaks of proteinoids [ 21 , 50 ] at 660 and 770 cm −1 (amine N-H wagging [ 56 ]) belonging to the arginine side chain, which possesses three atoms of nitrogen.…”

Section: Resultsmentioning

confidence: 99%

Tumor-Targeted Fluorescent Proteinoid Nanocapsules Encapsulating Synergistic Drugs for Personalized Cancer Therapy

et al. 2021

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Personalized cancer treatment based on specific mutations offers targeted therapy and is preferred over “standard” chemotherapy. Proteinoid polymers produced by thermal step-growth polymerization of amino acids may form nanocapsules (NCs) that encapsulate drugs overcoming miscibility problems and allowing passive targeted delivery with reduced side effects. The arginine-glycine-glutamic acid (RGD) sequence is known for its preferential attraction to αvβ3 integrin, which is highly expressed on neovascular endothelial cells that support tumor growth. Here, tumor-targeted RGD-based proteinoid NCs entrapping a synergistic combination of Palbociclib (Pal) and Alpelisib (Alp) were synthesized by self-assembly to induce the reduction of tumor cell growth in different types of cancers. The diameters of the hollow and drug encapsulating poly(RGD) NCs were 34 ± 5 and 22 ± 3 nm, respectively; thereby, their drug targeted efficiency is due to both passive and active targeting. The encapsulation yield of Pal and Alp was 70 and 90%, respectively. In vitro experiments with A549, MCF7 and HCT116 human cancer cells demonstrate a synergistic effect of Pal and Alp, controlled release and dose dependence. Preliminary results in a 3D tumor spheroid model with cells derived from patient-derived xenografts of colon cancer illustrate disassembly of spheroids, indicating that the NCs have therapeutic potential.

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Cytotoxicity assessment of palbociclib-loaded chitosan-polypropylene glycol nano vehicles for cancer chemotherapy

Cited by 25 publications

References 33 publications

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

Colorimetric sensing of cephradine through polypropylene glycol functionalized gold nanoparticles

Assessment of implantable drug delivery technology: poly (3-hydroxybutyrate) / polypropylene glycol films containing simvastatin

Tumor-Targeted Fluorescent Proteinoid Nanocapsules Encapsulating Synergistic Drugs for Personalized Cancer Therapy

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