Cytotoxicity assessment of antibiotics on Ctenopharyngodon idellus kidney cells by a sensitive electrochemical method

Wu, Guanlan; Ma, Ying; Yu, Yangyang; Xing, Yi; Yuan, Xing; Zhu, Xiaolin

doi:10.1007/s11356-020-12058-3

Cited by 8 publications

(2 citation statements)

References 39 publications

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“…They can be used to evaluate cell toxicity and cell proliferation inhibition. By assessing changes in purine compound levels, the toxicity and inhibitory effects of exogenous substances on cells can be evaluated, providing important references for persistent organic pollutants screening, toxicity assessment, and disease treatment (Wu et al, 2021(Wu et al, , 2022. Research has shown that environmental pollutants such as heavy metals and organic contaminants can inhibit various stages of purine metabolism within cells, leading to obstructions in purine synthesis, decomposition, and transport processes, thereby affecting cell function and metabolism (Ying et al, 2022;Ying et al, 2023).…”

Section: Introductionmentioning

confidence: 99%

Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons

Liu,

Wang,

Wang

et al. 2024

Toxicol Ind Health

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A rapid and sensitive assessment of the toxicity of oxygenated polycyclic aromatic hydrocarbons (OPAHs), widely distributed persistent organic pollutants in the environment, is crucial for human health. In this study, using high-performance liquid chromatography, the separation and detection of four purines, xanthine (X), guanine (G), adenine (A), and hypoxanthine (HX) in cells were performed. The aim was to evaluate the cytotoxicity of three OPAHs, namely 1,4-benzoquinone (1,4-BQ), 1,2-naphthoquinone (1,2-NQ) and 9,10-phenanthrenequinone (9,10-PQ), with higher environmental concentrations, from the perspective of purine nucleotide metabolism in human skin fibroblast cells (HFF-1). The results revealed that the levels of G and A were low in HFF-1 cells, while the levels of HX and X showed a dose-response relationship with persistent organic pollutants concentration. With increased concentration of the three persistent organic pollutants, the purine metabolism in HFF-1 cells weakened, and the impact of the three persistent organic pollutants on purine metabolism in cells was in the order of 9,10-PQ > 1,4-BQ > 1,2-NQ. This study provided valuable insights into the toxic mechanisms of 1,4-BQ, 1,2-NQ and 9,10-PQ, contributing to the formulation of relevant protective measures and the safeguarding of human health.

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Section: Introductionmentioning

confidence: 99%

Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons

Liu,

Wang,

Wang

et al. 2024

Toxicol Ind Health

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“…Carboxyl functionality also improves the adsorption properties and catalytic activity of the material. 18,19 Amino functionalization provides unique properties to MWCNTs. It can be attached to the surfaces of MWCNTs either covalently or non-covalently.…”

Section: Introductionmentioning

confidence: 99%

A designed miniature sensor for the trace level detection and degradation studies of the toxic dye Rhodamine B

et al. 2022

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Recent advances in electrochemical cell-based biosensors for food analysis: Strategies for sensor construction

Wei,

Reddy,

Gao

et al. 2024

Biosensors and Bioelectronics

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Cytotoxicity assessment of antibiotics on Ctenopharyngodon idellus kidney cells by a sensitive electrochemical method

Cited by 8 publications

References 39 publications

Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons

Evaluation on purine metabolism in human skin fibroblast cells exposed to oxygenated polycyclic aromatic hydrocarbons

A designed miniature sensor for the trace level detection and degradation studies of the toxic dye Rhodamine B

Recent advances in electrochemical cell-based biosensors for food analysis: Strategies for sensor construction

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