Cytotoxicity and mitogenicity of adenosine triphosphate in the cochlea

Bobbin, Richard P.; Chu, Sally; Skellett, Ruth A; Campbell, Julie M; Fallon, Maureen

doi:10.1016/s0378-5955(97)00140-8

Cited by 14 publications

(2 citation statements)

References 54 publications

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“…Chronic perfusion of the perilymphatic space with ATP causes the proliferation of fibrous tissue and neoosteogenesis in the scala tympani [Bobbin et al, 1997]. Such findings imply that high levels of ATP are mitogenic and would be consistent with activation of P2Y receptors that exist within the cochlear tissues.…”

Section: Potential Role For Purine Nucleotides In Cochlear Diseasementioning

confidence: 86%

Potential Role of Purinergic Signalling in Cochlear Pathology

et al. 2002

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Adenosine triphosphate (ATP) is a major intercellular signalling molecule that is involved in neurotransmission in the central and autonomic nervous systems, regulation of blood flow, and neuroendocrine function. It is also a key signalling molecule involved in normal cochlear homoeostasis, regulating hearing sensitivity, controlling vascular tone and acting as a candidate neurotransmitter at the hair cell afferent synapses. It has also been established that extracellular ATP mediates some pathological processes such as inflammation, apoptosis and cell proliferation. Evidence for a profound influence of extracellular ATP on normal cochlear function offers the tantalising possibility that extracellular purine nucleotides may play a role in disease processes in the inner ear. This review draws on the current understanding of the pathophysiological role of extracellular ATP in tissues, and the evidence for the functional expression of purinergic signalling elements in the inner ear, to speculate on the potential role of purine nucleotides in cochlear pathology.

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Section: Potential Role For Purine Nucleotides In Cochlear Diseasementioning

confidence: 86%

Potential Role of Purinergic Signalling in Cochlear Pathology

et al. 2002

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“…ATP and its P2 receptors modulate synaptic conduction in the central and peripheral nervous systems [2] and extracellular ATP attenuates cochlear function via the P2 receptors [3][4][5]. There have been many studies of the acute administration and effects of ATP, but few reports on the chronic effects of ATP administration [6]. In addition, ATP has been widely used in the treatment of sensorineural hearing loss involving acoustic trauma, but evidence that ATP can in fact protect the inner ear under these circumstances is unclear.…”

Section: Introductionmentioning

confidence: 99%

Cochlear Administration of Adenosine Triphosphate Facilitates Recovery from Acoustic Trauma (Temporary Threshold Shift)

Sugahara

Shimogori

Okuda

et al. 2004

ORL

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Background: Adenosine triphosphate (ATP) has often been used in the treatment of acoustic trauma although evidence supporting its clinical use was lacking. The aim of this study was to evaluate the chronic effects of ATP on acoustic trauma in guinea pigs. Methods: We infused ATP into the perilymph of the guinea pig cochlea concurrently with intense noise exposure to investigate the effect of ATP on the process of recovery after acoustic trauma. We assessed auditory brainstem response (ABR) thresholds to evaluate cochlear function. Results: After noise exposure (120 dB SPL, 5 h), ABR thresholds showed an increase of approximately 50 dB SPL that returned to normal after 14 days. Cochlear function in ATP-treated ears recovered more quickly than in control ears. The effect of ATP was inhibited by the administration of the ATP receptor antagonist: pyridoxal- phosphate-6-azophenyl-2′,4′-disulfonic acid. Conclusion: These results suggest that ATP mitigates the effects of noise trauma through the ATP receptor.

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Nucleoside and Nucleotide Transmission in Sensory Systems

Housley¹

2001

Purinergic and Pyrimidinergic Signalling I

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Cytotoxicity and mitogenicity of adenosine triphosphate in the cochlea

Cited by 14 publications

References 54 publications

Potential Role of Purinergic Signalling in Cochlear Pathology

Potential Role of Purinergic Signalling in Cochlear Pathology

Cochlear Administration of Adenosine Triphosphate Facilitates Recovery from Acoustic Trauma (Temporary Threshold Shift)

Nucleoside and Nucleotide Transmission in Sensory Systems

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