Cytotoxicity and Inhibition of Lymphocyte Proliferation of Fasciculatin, a Linear Furanosesterterpene Isolated from Ircinia variabilis Collected from the Atlantic Coast of Morocco

Abstract

Fasciculatin, a furanosesterterpene isolated from the marine sponge Ircinia variabilis from the Atlantic Coast of Morocco, has been evaluated for its influence on a mitogen-induced proliferation of human lymphocytes and growth of human tumor cell lines.

Monitoring Bacterial Diversity of the Marine Sponge Ircinia strobilina upon Transfer into Aquaculture

“…I. strobilina contains variabilin, a furanosesterterpene that has been identified as a fish feeding deterrent (16). A diverse group of metabolites has been found from other sponges in the genus Ircinia and includes other sesterterpenes (1,3,29,38,52,65,76). The compounds ircinal A and B, precursors of antimalarial manzamine alkaloids, were isolated from the Okinawan marine sponge Ircinia sp.…”

Haliscosamine: a new antifungal sphingosine derivative from the Moroccan marine sponge Haliclona viscosa

“…The activity of this product also shows the bioactive potential of marine sponges from the Atlantic Coast of Morocco, and encourages them to continue our sorting activity. The only study that has been done before has been the isolation of untenospongin B (antimicrobial) from the marine sponge Hippospongia communis (Rifai et al 2004) and of fasciculatin (cytotoxic and inhibitor of lymphocyte proliferation) isolated from Ircinia variabilis (Rifai et al 2005). …”

“…The MIC 90 (the lowest concentration causing at least 90% of growth inhibition when compared to drug-free control) of the isolated compound was measured using the method described by Rifai et al (2005). Yeast Morphological Broth medium was used as test media.…”

ChemInform Abstract: Irciformonins E—K, C22‐Trinorsesterterpenoids from the Sponge Ircinia formosana.

“…The structures were determined by interpretation of HR-ESI-MS and 2D-NMR spectra. Some furanosesterterpenes were reported to possess antimicrobial [13], cytotoxic [14] [15], and inhibition of lymphocytic proliferation activities [14]. Compound 5 exhibited significant inhibition of peripheral blood mononuclear cell proliferation induced by phytohemaglutinin.…”

“…-Sponges (poriferans) are simple sedentary marine organisms that produce a wide variety of secondary metabolites that may act as a chemical defense against microorganisms and predators [1] [2]. Some furanosesterterpenes were reported to possess antimicrobial [13], cytotoxic [14] [15], and inhibition of lymphocytic proliferation activities [14]. Several steroid [4], sphingolipid [5], alkaloid [6], hydroquinone [7], and cyclic hexapeptide [8] derivatives have been isolated from this genus, in addition to furanosesterterpenes (¼ a furan-moiety-containing sesterterpenes) which are considered as one of the major constituents [9] [10].…”