Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents

Cimanga, R.K.; Kambu, K.; Tona, L.; Hermans, Nina; Apers, Sandra; Totté, J.; Pieters, Luc; Vlietinck, A. J.

doi:10.1016/j.jep.2006.02.010

Cited by 52 publications

(34 citation statements)

References 38 publications

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“…While the literature data point out the presence of saponins, flavonoids, terpenes, steroids, tannins and anthraquinones, the absence of anthocyanes and the doubtful presence of alkaloids in Morinda morindoides leaves (Kambu, 1990), extensive phytochemical studies on this medicinal plant part have led to the isolation and structure elucidation of flavonoids (Cimanga et al, 1995a(Cimanga et al, , 1997, iridoids (Cimanga et al, 2003) and anthraquinones (Cimanga et al, 2008). Some interesting biological activities related to some of its traditional uses including the in vitro and in vivo antimalarial (Onabanjo, 1983;Cimanga et al, 2008), the in vitro anticomplementary (Cimanga et al, 1995b(Cimanga et al, , 1997(Cimanga et al, , 2003, antioxidative ), cardioinhibitory (N'Guessan et al, 2002, antiamoebic (Cimanga et al, 2006) and immunologic (Mankele et al, 2006) activities, were previously reported. However, the plant part has not been studied for its putative antispasmodic activity.…”

Section: Introductionmentioning

confidence: 97%

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cimanga

Mukenyi

Kambu

et al. 2010

Journal of Ethnopharmacology

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Section: Introductionmentioning

confidence: 97%

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Cimanga

Mukenyi

Kambu

et al. 2010

Journal of Ethnopharmacology

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“…Cosmosiin also showed the anti-amoeba activity with IC 50 22.3µg/mL. 10 The other study showed that several flavonoid compounds that capable to inhibit HIV-1 RT enzyme. Xanthohumol, prenylchalcone from Humulus lupulus are able to inhibit the replication of HIV-1 in PBMCs with EC 50 20.74 mg/ mL.…”

Section: Discussionmentioning

confidence: 91%

Inhibition of HIV-1 Reverse Transcriptase of Selected Indonesia Medicinal Plants and Isolation of the Inhibitor from Erythrina variegata L. Leaves

Wardani¹,

Mun’im²,

Yanuar³

2018

JYP

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Objective: This research was conducted to screen inhibition of HIV-1 reverse transcriptase activity of selected Indonesia medicinal plants and to isolate HIV-1 reverse transcriptase inhibitor from Erythrina variegata leaves. Method: Screening inhibition of HIV-1 RT activity of selected Indonesia medicinal plants and isolated compounds were performed using HIV-1 RT colorimetric assay. The isolation of HIV-1 reverse transcriptase inhibitor was conducted using chromatography technique. The isolated compound was determined based on the data of UV, IR spectrophotometry, MS, 1D and 2D NMR spectroscopy. Results: Beside that, in vitro study of the leaves methanolic extract exhibited inhibition against HIV-1 RT activity with percent inhibition of 97.64% at concentration of 5 mg/mL. Ethyl acetate fraction from the extract showed the strongest HIV-1 RT inbitory activity with IC 50 of 429.28 µg/mL. Isolation the HIV-1 RT inhibitor from the fraction give compound 1. Conclusion: Erythrina variegata leave extract exhibited potent inhibition on HIV-1 RT activity. The isolated compound from the leaves was determined as apigenin-7-O-β-D-glucopyranoside and demonstrated HIV-1 RT inhibitory activity with the IC 50 value of 100.59 µg/mL. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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“…These flavonoids exhibited various biological activities including inhibition of xanthine oxidase and scavenging of superoxide anions , anticomplementary activity (Cimanga et al 2003), and antiamoebic activity (Cimanga et al 2006). It was also found that crude extracts from M. morindoides exhibited in vitro and in vivo antimalarial activity (Tona et al , 2001(Tona et al , 2004Mbatchi et al 2006;Tamura et al 2010;Temidayo et al 2010).…”

Section: Introductionmentioning

confidence: 95%

Evaluation of antioxidant potentials ofMorinda morindoidesleaf extract

Akinloye

Sunmonu

Omotainse

et al. 2015

Toxicological & Environmental Chemistry

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This study investigated antioxidant status of animals given aqueous extract of Morinda morindoides leaves using the levels of reduced glutathione, total-thiol, vitamin C, and vitamin E as well as malondialdehyde concentrations as indices, and its in vitro antioxidant capacity. Thirty rats divided into five groups were used. Group A served as control and were administered distilled water while groups B, C, D, and E were given 100, 200, 400, and 800 mg per kilogram body weight of water-extracted constituents of M. morindoides for 28 days. Total phenolic compounds amounted to 83.6 § 5.9 mg g ¡1 gallic acid equivalent, while total flavonoid content was 9.5 § 0.9 mg g ¡1 pyrocathecol equivalent. Malondialdehyde in plasma was significantly decreased in a dose-dependent manner, ranging from 21% in groups B and C to 84% in groups D and E. Vitamins C and E were significantly increased, in group E by 91% and 17% compared with control. Total thiols and glutathione in plasma were significantly increased, with group E having 2.5-fold and 4.2-fold higher values than control.

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Cytotoxicity and in vitro susceptibility of Entamoeba histolytica to Morinda morindoides leaf extracts and its isolated constituents

Cited by 52 publications

References 38 publications

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

The spasmolytic activity of extracts and some isolated compounds from the leaves of Morinda morindoides (Baker) Milne-Redh. (Rubiaceae)

Inhibition of HIV-1 Reverse Transcriptase of Selected Indonesia Medicinal Plants and Isolation of the Inhibitor from Erythrina variegata L. Leaves

Evaluation of antioxidant potentials ofMorinda morindoidesleaf extract

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