Cytotoxicity and<i>in vitro</i>characterization studies of synthesized Jeffamine-cored PAMAM dendrimers

Öztürk, Kıvılcım; Ertürk, Ali; Sarısözen, Can; Tülü, Metin; Çalış, Sema

doi:10.3109/02652048.2013.814727

Cited by 18 publications

(10 citation statements)

References 39 publications

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“…On the other hand, PAMAM-COOH dendrimers were prepared by slight modification of the literature procedure 24 and our recent study. 25 The results were in good agreement with the literature. 23,27 General procedures for the preparation and characterization PAMAM-COOH dendrimers were given in the supplementary material.…”

Section: Synthesis Of Pamamssupporting

confidence: 82%

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Preparation of Cu Nanocomposites from EDA, DETA, and Jeffamine Cored PAMAM Dendrimers with TRIS and Carboxyl Surface Functional Groups

Ertürk

Gürbüz

Tülü

et al. 2016

ACSi

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This study presents the synthesis and UV-Vis characterization of Cu nanocomposites from ethylenediamine (EDA) (E), diethylenetriamine (DETA) (D), and Jeffamine® T-403 (P) cored PAMAM dendrimers (PAMAMs) with TRIS and carboxyl surface functional groups. Cu-PAMAM dendrimer encapsulated nanoparticles (Cu-DENs) were characterized by UV-Vis spectroscopy. Disappearance of the 680 nm d-d transition and 270-300 nm ligand to metal charge transfer (LMCT) peaks and the formation of monotically increasing exponential band were used as the evidence of the successful synthesis of Cu-DENs in addition to immediate color change of dendrimer-metal mixture solutions from blue to golden brown by reduction. Synthesized Cu-DENs could be facilitated as novel alternatives to the existing nanomaterials used in a wide range of applications involving bio and chemical sensors, catalysis, hydrogenations, oxidations, semiconductors, noble metals, magnetic dendrimer nanocomposites, environmental cleanup and many others.

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Section: Synthesis Of Pamamssupporting

confidence: 82%

“…PAMAM-COOH dendrimers (Cn.COOH) were prepared by the slight modification of literature procedure, 24 and our previous study. 25 During the synthesis of PAMAM-COOH dendrimers, briefly, a methanolic solution of esterterminated PAMAM dendrimers (PAMAM-OCH 3 ) (Cn.5) dendrimers was mixed with 1.5 M equiv. of NaOH per terminal ester.…”

Section: Synthesis Of Pamamsmentioning

confidence: 99%

Preparation of Cu Nanocomposites from EDA, DETA, and Jeffamine Cored PAMAM Dendrimers with TRIS and Carboxyl Surface Functional Groups

Ertürk

Gürbüz

Tülü

et al. 2016

ACSi

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“…Amine-terminated PAMAM dendrimers (PAMAM-NH 2 ) are water-soluble and mostly present in protonated conformation at the pH media of the living cells' physiological functions. 22,23 Ideally, an interaction between a drug carrier or delivery system and a cell is expected. This phenomenon has a negative effect on the future development of clinical applications of amine terminated dendrimers.…”

Section: Synthesis Of Pamam-tris Dendrimersmentioning

confidence: 99%

Water-soluble TRIS-terminated PAMAM dendrimers: microwave-assisted synthesis, characterization and Cu(ii) intradendrimer complexes

et al. 2015

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This study is the first report describing the microwave-assisted synthesis (MAS) of poly(amido amine) (PAMAM) dendrimers with TRIS surface functional groups (PAMAM-TRIS). Six PAMAM-TRIS dendrimers were synthesized using both newly developed conventional and microwave methods. Five of them are novel. Three different cores, one polymeric Jeffamine® T-403 and two monomeric, ethylenediamine and diethylenetriamine, were used in the syntheses. All the reactions were monitored by attenuated total reflectance (ATR). It was observed that microwave reactions proceeded 3.5 to 4.0 times faster than conventional reactions. Therefore, a fast, easy and one-pot MAS of six different water-soluble PAMAM-TRIS dendrimers was accomplished with high (90-96%) yields in short (110-140 min) reaction times and under mild reaction conditions, using methanol as solvent. The other ester terminated half generation precursor PAMAM (PAMAM-OCH 3 ) dendrimers used for the synthesis of the PAMAM-TRIS dendrimers were obtained by utilizing conventional and microwave methods together. For the purification of all the PAMAM dendrimers, a liquid phase polymer-based retention (LPR) technique was used. The PAMAM-TRIS dendrimers were characterized by 1 H NMR, 13 C NMR, ATR (IR), EA, potentiometric and spectroscopic titrations. Furthermore, Cu(II)-PAMAM-TRIS dendrimer complexes were prepared and characterized by UV-Vis spectroscopy. The synthesized PAMAM-TRIS dendrimers can be considered as new drug carrier systems and should find use in widespread application fields, especially in future pharmaceutical and catalytic studies but also in other fields.

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“…Poly(amidoamine) PAMAM‐based dendrimers with surface modifications have been reported as potent antibacterial agents . Tulu et al synthesized jeffamine PAMAM dendrimers, where the highest generation of anionic dendrimers showed the lowest cytotoxicity for L929 cells, while the first generation was water‐soluble revealing a higher antibacterial activity . Chen et al reported on the preparation of poly(propylene imine) (PPI) dendrimers based on quaternary ammonium moieties as potent biocides and biocidal activities depending on the size of the dendrimer, the length of hydrophobic chain and the counter anions .…”

Section: Introductionmentioning

confidence: 99%

Amphiphilic water soluble cationic ring opening metathesis copolymer as an antibacterial agent

Islam

Aksu

Güncü

et al. 2020

Journal of Polymer Science

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Bacterial infection is a global problem, especially resistance acquired by bacteria against to antibiotics; there is urgent need for the development of antibiotics. Here, we proposed dendron‐grafted polymers via ring opening metathesis polymerization (ROMP) featuring different with tailored hydrophobicity/hydrophilicity and cationic charges. Dendritic oxanorbornene derivatives were synthesized having two and six carbon linkers and their corresponding random and block copolymers were prepared having pendant pyridinium salt moieties via ROMP. In total, 12 different water‐soluble dendronized cationic polymers featuring hexyl pyridinium moieties were prepared and investigated. Six carbon linker possessing triple charge density and hexyl pyridinium functionality each repeating unit copolymers exhibited high antibacterial activity against Gram‐positive bacteria (S. aureus). However, all the polymers were inactive against Gram‐negative bacteria (E. coli). Most of the copolymers are non‐hemolytic (>HC 50 = 1,000 μg/ml). It was also observed that, there is no significant effect between block copolymers and random copolymers keeping hydrophobicity and cationic charge density constant. Zeta potential was measured to investigate the mechanism in solution via the interaction of polymers with S. aureus, while scanning electron microscope (SEM) measurements image confirms damage of the bacterial cell wall after implementation of biocidal polymer.

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Cytotoxicity andin vitrocharacterization studies of synthesized Jeffamine-cored PAMAM dendrimers

Cited by 18 publications

References 39 publications

Preparation of Cu Nanocomposites from EDA, DETA, and Jeffamine Cored PAMAM Dendrimers with TRIS and Carboxyl Surface Functional Groups

Preparation of Cu Nanocomposites from EDA, DETA, and Jeffamine Cored PAMAM Dendrimers with TRIS and Carboxyl Surface Functional Groups

Water-soluble TRIS-terminated PAMAM dendrimers: microwave-assisted synthesis, characterization and Cu(ii) intradendrimer complexes

Amphiphilic water soluble cationic ring opening metathesis copolymer as an antibacterial agent

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