Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review

Maleki, Masomeh; Golchin, Asal; Alemi, Forough; Younesi, Simin; Asemi, Zatollah; Javadi, Samira; Khiavi, Payam Ali; Soleinmapour, Jafar; Yousefi, Bahman

doi:10.1016/j.ejphar.2021.174131

Cited by 10 publications

(5 citation statements)

References 43 publications

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“…The preparation of water-insoluble drugs as nanoformulations causes an increase in the surface area and thus, an increase in solubility. The safe development of nanotechnology and the use of NPs require the consideration of cellular toxicity of those NPs . Seko et al develop and characterize polylactide-co-glycolide (PLGA) nanoparticles (NPs).…”

Section: Resultsmentioning

confidence: 99%

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Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

et al. 2023

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Ovarian cancer, which is one of the most diagnosed cancer types among women, maintains its significance as a global health problem. Several drug candidates have been investigated for the potential treatment of ovarian cancer. Nonsteroidal anti-inflammatory drugs (NSAIDs) demonstrated anti-cancer activity through the inhibition of cyclooxygenase 2 (COX-2) and by inhibiting COX-2-dependent prostaglandin (PG) production. Naproxen is one of the most used NSAIDs and Naproxen-derived compounds (NDCs) may show potential treatment effects on cancer as chemotherapeutic drugs. Although there are successful drug development studies, the lack of solubility of these drug candidates in aqueous media results in limited bioavailability and high variability of patient responses during treatment. Low aqueous solubility is one of the main problems in the pharmaceutical industry in terms of drug development. Nanotechnology-based strategies provide solutions to hydrophobic drug limitations by increasing dispersion and improving internalization. In this study, two different NDCs (NDC-1 and NDC-2) bearing a thiosemicarbazide/1,2,4-triazole moiety were synthesized and tested for chemotherapeutic effects on ovarian cancer cells, which have a high COX-2 expression. To overcome the limited dispersion of these hydrophobic drugs, the drug molecules were conjugated to the surface of 13 nm AuNPs. Conjugation of drugs to AuNPs increased the distribution of drugs in aqueous media, and NDC@AuNP conjugates exhibited excellent colloidal stability for up to 8 weeks. The proposed system demonstrated an increased chemotherapeutic effect than the free drug counterparts with at least 5 times lower IC50 values. NDC@AuNP nanosystems induced higher apoptosis rates, which established a simple and novel way to investigate activity of prospective drugs in drug discovery research.

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Section: Resultsmentioning

confidence: 99%

“…The safe development of nanotechnology and the use of NPs require the consideration of cellular toxicity of those NPs. 40 Seko et al develop and characterize polylactide-co-glycolide (PLGA) nanoparticles (NPs). They determined their effects on the line IC50 values.…”

Section: Resultsmentioning

confidence: 99%

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

et al. 2023

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“…Approximately two to three decades ago, nanostructured materials became an important asset to modern society and the global economy. Strategic sectors that are custodians of nanoscience include; pharma, biomedicine, agriculture, food technology, energy, and water purification 41 . The use of nanomaterials and discard of waste emanating from these sectors may result in leaching or erosion of nanomaterials into the environment.…”

Section: Resultsmentioning

confidence: 99%

“…Strategic sectors that are custodians of nanoscience include; pharma, biomedicine, agriculture, food technology, energy, and water purification. 41 The use of nanomaterials and discard of waste emanating from these sectors may result in leaching or erosion of nanomaterials into the environment. An area of concern is their potential to become secondary pollutants and lead to bioaccumulation within ecosystems.…”

Section: Cytoxicity Studiesmentioning

confidence: 99%

Fabrication of Ag₂S‐incorporated polyamide thin film nanocomposite reverse osmosis membranes with antifouling properties

Nchoe,

Matshetshe,

As' Ballim

et al. 2023

J of Applied Polymer Sci

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Herein we report on the fabrication of polyamide (PA) thin‐film composites (TFC) as reverse osmosis (RO) membranes with embedded silver sulfide (Ag2S) nanoparticles (NPs) to form thin‐film nanocomposites (TFN) and mitigate fouling. The fabrication of TFN membranes was done via interfacial polymerization on a polysulfone support membrane. Varied amounts of Ag2S NPs (20, 30, and 50 mg) were added to the aqueous phase to form membranes with enhanced antifouling and permselectivity performance. The chemical composition, surface topography, resistance to organic fouling and biofouling, water flux, and salt rejection, were tested on all membranes. The formation of Ag2S was confirmed by XRD and transmission electron microscopy. The pure water flux (Jo) obtained by all TFN membranes was above 25 L/m2h. Moreover, the 30 mg loaded TFN membrane attained the highest Jo of 32.7 L/m2h. Salt rejection of the nanocomposite membranes were observed to be above 98%, which deems them suitable materials for desalination. TFN demonstrated resistance to fouling by bovine serum albumin and was able to retard bacterial colony formation. This was attributed to antibacterial properties of Ag2S NPs. Moreover, surface roughness decreased with increased NP loading, which also reduced the propensity of fouling.

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“…In the realm of nanotechnology-based drug delivery for osteosarcoma therapy, designing nanoparticles that evade clearance by the immune system is a critical challenge. However, even once this challenge is addressed, researchers must consider the physicochemical properties of the nanoparticles, such as particle size, surface charge, hydrophobicity, drug binding, encapsulation rate, and bioavailability, since these properties are associated with varying levels of cytotoxicity (Maleki et al, 2021;Wu et al, 2022). To address these challenges, hybrid nanoparticles, such as peptidedecorated polymeric micelles, are being developed.…”

Section: Biodistribution Clearance and Nanotoxicitymentioning

confidence: 99%

Polymer-based nanosystems and their applications in bone anticancer therapy

Nafo

2023

Front. Chem.

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The mortality rate of bone cancer has witnessed a substantial reduction in recent years, all thanks to the advent of advanced cancer treatment modalities such as surgical intervention, radiation, and chemotherapy. Nevertheless, these popular modalities come with a set of clinical challenges, including non-specificity, side effects, and drug intolerance. In recent years, polymer-based nanosystems have emerged as a promising solution in bone anti-cancer therapy by virtue of their unique physical and chemical properties. These nanosystems can be tailored for use in different drug release mechanisms for therapeutic implementations. This review delves into the efficacy of these therapy applications in bone cancer (with a focus on one of the most common types of cancers, Osteosarcoma) treatment and their correlation with the properties of polymer-based nanosystems, in addition to their interaction with the tumor microenvironment and the biological milieu.

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Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review

Cited by 10 publications

References 43 publications

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Fabrication of Ag₂S‐incorporated polyamide thin film nanocomposite reverse osmosis membranes with antifouling properties

Polymer-based nanosystems and their applications in bone anticancer therapy

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Cytotoxicity and apoptosis of nanoparticles on osteosarcoma cells using doxorubicin and methotrexate: A systematic review

Cited by 10 publications

References 43 publications

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Investigation of Gold Nanoparticle Naproxen-Derived Conjugations in Ovarian Cancer

Fabrication of Ag2S‐incorporated polyamide thin film nanocomposite reverse osmosis membranes with antifouling properties

Polymer-based nanosystems and their applications in bone anticancer therapy

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Product

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Fabrication of Ag₂S‐incorporated polyamide thin film nanocomposite reverse osmosis membranes with antifouling properties