Cytotoxicity and apoptogenic effects of Lafoensia pacari

Marcondes, Daniela Beck da Silva; Reichert, Cristiane Loiva; Andrade, Lucas Ferrari de; Santos, Cid Aimbiré de Moraes; Weffort-Santos, Almeriane Maria

doi:10.1016/j.jep.2014.09.018

Cited by 9 publications

(2 citation statements)

References 29 publications

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“…This biome has a wide variety of medicinal plants used in folk medicine. Many of these plants have been investigated, and their antioxidant [2], antimicrobial [3], antidiabetic [4], anti-inflammatory [5], and cytotoxic [6] activities, among others, have been scientifically proven.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

et al. 2016

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Hancornia speciosa Gomes (Apocynaceae) is a fruit tree, popularly known as mangabeira, and it is widely distributed throughout Brazil. Several parts of the plant are used in folk medicine, and the leaf and bark extracts have anti-inflammatory, antihypertensive, antidiabetic, and antimicrobial properties. In this study, we investigated the chemical composition of the ethanolic extract of Hancornia speciosa leaves (EEHS) and its antioxidant, antimicrobial, and cytotoxic activities as well as the mechanisms involved in cell death. The chemical compounds were identified by liquid chromatography coupled to mass spectrometry (LC-MS/MS). The antioxidant activity of the EEHS was investigated using the method that involves the scavenging of 2,2-diphenyl-1-picrylhydrazyl free radicals as well as the inhibition of oxidative hemolysis and lipid peroxidation induced by 2,2’-azobis (2-amidinopropane) in human erythrocytes. The antimicrobial activity was determined by calculating the minimum inhibitory concentration, minimum bactericidal concentration, minimum fungicidal concentration, and zone of inhibition. Kasumi-1 leukemic cells were used to assess the cytotoxic activity and mechanisms involved in cell death promoted by the EEHS. The chemical compounds identified were quinic acid, chlorogenic acid, catechin, rutin, isoquercitrin, kaempferol-rutinoside, and catechin-pentoside. The EEHS demonstrated antioxidant activity via the sequestration of free radicals, inhibition of hemolysis, and inhibition of lipid peroxidation in human erythrocytes incubated with an oxidizing agent. The antimicrobial activity was observed against American Type Culture Collection (ATCC) and hospital strains of bacteria and fungi, filamentous fungi and dermatophytes. The cytotoxic activity of the EEHS was induced by apoptosis, reduction of the mitochondrial membrane potential, and activation of cathepsins. Together, these results indicate the presence of phenolic compounds and flavonoids in the EEHS and that their antioxidant, antimicrobial, and cytotoxic activities in acute myeloid leukemia cells are mediated by apoptosis.

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Section: Introductionmentioning

confidence: 99%

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

et al. 2016

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“…É sabido que a formação que tenha como foco a aprendizagem da liderança, administração e gerenciamento, comunicação, tomada de decisão e educação permanente contribui para alcançar conhecimentos, habilidades e atitudes, ou seja, competências gerenciais para o processo de trabalho em saúde (3) . Destaca-se, neste estudo, a tomada de decisão como competência gerencial do enfermeiro, que pode ser aprendida durante a formação acadêmica, além do campo teórico, realizando uma abordagem prática por meio da simulação realística, considerada estratégia metodológica que beneficia o estudante durante sua graduação (4) .…”

Section: Introductionunclassified

Tomada de Decisão Gerencial do Enfermeiro da Área Hospitalar: construção e validação de cenário de simulação

Ribeiro

Leal

Ferreira

et al. 2023

Rev. Latino-Am. Enfermagem

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Resumo Objetivo: construir e validar um cenário de simulação clínica sobre a competência tomada de decisão gerencial do enfermeiro hospitalar para estudantes de graduação em enfermagem. Método: estudo descritivo e metodológico realizado em uma instituição de ensino superior, com a participação de 10 juízes e cinco atores. Utilizou-se o modelo conceitual de simulação proposto por Jeffries e guias padronizadas da International Nursing Association for Clinical Simulation in Learning para a elaboração do cenário e do checklist. Resultados: o cenário ficou denominado como “Tomada de decisão gerencial do enfermeiro diante de eventos adversos no contexto hospitalar”. Construiu-se o script do cenário e o checklist para a sua validação. Realizou-se validação de face e conteúdo do checklist. Posteriormente, juízes de posse do checklist, validaram o cenário que, em sua versão final, ficou composto por Prebriefing (sete itens), Cenário em Ação (18 itens) e Debriefing (sete itens). Conclusão: o cenário mostrou-se uma estratégia de ensino capaz de antecipar a realidade do futuro enfermeiro, trazendo autoconfiança na execução de suas atividades, contribuindo para agir de forma crítica e reflexiva durante o processo de tomada de decisão.

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Biological Evaluation of in vitro Cytotoxicity of Extracts of Lafoensia glyptocarpa Koehne (Lythraceae)

Faria,

Ambrosio,

Lombello

et al. 2023

IFMBE Proceedings

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Cytotoxicity and apoptogenic effects of Lafoensia pacari

Abstract: The data have clearly shown that exposition of human tumor cell lines to Lafoensia pacari stem barks extract leads to apoptosis induction due to cell cycle arrest in G0/G1 phases, supporting its anticancer use.

Cited by 9 publications

References 29 publications

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

Tomada de Decisão Gerencial do Enfermeiro da Área Hospitalar: construção e validação de cenário de simulação

Biological Evaluation of in vitro Cytotoxicity of Extracts of Lafoensia glyptocarpa Koehne (Lythraceae)

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