Cytotoxicity and antiviral activity of electrochemical – synthesized silver nanoparticles against poliovirus

Huy, Tran Quang; Thanh, Nguyen Thi Hien; Thuy, Nguyen Thanh; Chung, Pham Van; Hung, Pham Ngoc; Le, Anh‐Tuan; Hạnh, Nguyễn Thị Hồng

doi:10.1016/j.jviromet.2016.12.015

Cited by 123 publications

(65 citation statements)

References 33 publications

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“…Pure AgNPs, synthesized by the electrochemical method were tested against poliovirus by adding different concentrations of AgNPs were added to human rhabdomyosarcoma (RD) monolayer cells before viral infection [33]. The results confirm silver protection against poliovirus infection, with the cell viability up to 98% at 48 h postinfection [33]. For the food industry it is important to avoid viral infections within a big farm where the animals are cultured and are crowded.…”

Section: Antiviral Propertiesmentioning

confidence: 82%

“…In human cells the addition of AgNPs could inhibit enzymes responsible for DNA replication, a crucial process for further viral infection [31]. Pure AgNPs, synthesized by the electrochemical method were tested against poliovirus by adding different concentrations of AgNPs were added to human rhabdomyosarcoma (RD) monolayer cells before viral infection [33]. The results confirm silver protection against poliovirus infection, with the cell viability up to 98% at 48 h postinfection [33].…”

Section: Antiviral Propertiesmentioning

confidence: 85%

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Biological Activity of Silver Nanoparticles and Their Applications in Anticancer Therapy

Skonieczna¹,

Hudy²

2018

Silver Nanoparticles - Fabrication, Characterization and Applications

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Nanotechnology delivers materials and nanoparticles (NPs) with high biological potential, useful in bioengineering, nanomedicine, and human health protection. Silver nanoparticles (NPs), because of their wide spectrum of activities and physical and chemical properties, are nowadays extensively researched. However, careful studies on living organism should be performed, with strong attention to biocompatibility. Multiple cellular effects, displayed after AgNP treatments, show interesting potential of metal-based NPs, not only in bio-nanotechnology but also in molecular medicine and anticancer therapy. AgNPs are promising anticancer agents, influencing the cell cycle, inhibiting cancer proliferation, and inducing oxidative stress and propagation of programmed cellular death (apoptosis). Additionally, they protect against bacterial, fungal, and viral infections. During chemo-and radio-therapies, such antimicrobial protection will be desirable because of the decreased immunological resistance of cancer patients. In conclusion, AgNPs often present in the human environment should be studied for novel findings and better characteristic. This article discusses advantages of AgNP's "eco-friendly" production, followed by green synthesis, with particular consideration of antimicrobial and anticancer properties. Cellular processes, induced after AgNP treatments, are focused on antiproliferative, pro-oxidative, and pro-apoptotic activities of NPs.

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Section: Antiviral Propertiesmentioning

confidence: 82%

Section: Antiviral Propertiesmentioning

confidence: 85%

Biological Activity of Silver Nanoparticles and Their Applications in Anticancer Therapy

Skonieczna¹,

Hudy²

2018

Silver Nanoparticles - Fabrication, Characterization and Applications

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“…80 AgNP is also toxic to virus such as norovirus 81 and poliovirus. 82 However, AgNP was found to be ineffective against MS2 bacteriophage. 83 Silver nanoparticles has made its way into POU water treatment systems for the developing communities.…”

Section: Nanotechnologymentioning

confidence: 99%

Review of low-cost point-of-use water treatment systems for developing communities

Pooi

2018

npj Clean Water

147

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For communities in developing countries, the majority of drinking water-related issues are due to pathogens from poor sanitation, resulting in infection and diarrhea. One cause of this is that these communities often do not have access to centralized water treatment facilities. Point-of-use (POU) systems are key solutions for treating water in developing communities; they are typically user-friendly, low cost, low maintenance, and grid-independent. Importantly, they treat and reduce the number of pathogens in water supplies, and many POU systems have been deployed and used by these communities, improving their livelihood. This review focuses on POU systems that cater to households or communities, with the aim to examine and evaluate technologies that have been implemented in POU systems in the past decade.

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“…Silver nanoparticles (Ag‐NPs) are well‐known metallic nanoparticles, with a number of advantages, including good conductivity and chemical stability. Ag‐NPs also exhibit antimicrobial effects against bacteria and viruses . Traditional antibiotics may destroy microorganisms by generating reactive oxygen species (ROS), and Ag‐NPs also have pro‐inflammatory activities and can augment the antimicrobial activities of ROS .…”

Section: Introductionmentioning

confidence: 99%

“…Ag-NPs also exhibit antimicrobial effects against bacteria and viruses. 1,2 Traditional antibiotics may destroy microorganisms by generating reactive oxygen species (ROS), and Ag-NPs also have proinflammatory activities and can augment the antimicrobial activities of ROS. 3 Many experiments have established that combinations of Ag-NPs and antimicrobial peptides (AMPs) have synergistic effects.…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles induce Egr‐1‐dependent psoriasin expression via the ERK and p38 pathways

et al. 2018

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Summary Background Silver nanoparticles (Ag‐NPs) can prevent bacterial infection and improve cutaneous wound healing owing to their antimicrobial activity. However, the mechanism of their antimicrobial activity is poorly understood. Aim To determine the mechanistic relationship between Ag‐NP treatment and expression of psoriasin. Methods Human epidermal keratinocytes, neonatal (HEKn) were used. Psoriasin mRNA expression was measured by reverse transcription PCR and real‐time PCR. Western blotting was performed to verify expression of early growth response‐1 (Egr‐1) and psoriasin, and phosphorylation of mitogen‐activated protein kinase (MAPK). Psoriasin promoter activity by Egr‐1 was detected by a luciferase assay. Results Treatment of HEKn with Ag‐NPs induced psoriasin mRNA and protein expression. Upregulation of psoriasin promoter activity was also observed in the luciferase assay. Ag‐NPs increased Egr‐1 expression, promoter activity and nuclear translocation in HEKn. Psoriasin luciferase activity was increased in HEKn transfected with Egr‐1 pcDNA 3.1. Ag‐NPs activated MAPK pathways including the extracellular signal‐regulated kinase (ERK), p38, and c‐Jun‐N‐terminal kinase (JNK) pathways. The upregulation of Egr‐1 expression by Ag‐NP stimulation was inhibited by ERK and p38 inhibitors, but not by a JNK inhibitor. Psoriasin expression was reduced in Egr‐1 small interfering RNA‐transfected HEKn. Conclusions Ag‐NP treatment induces upregulation of psoriasin expression through Egr‐1 expression. We suggest that the ERK and p38 pathways are involved in Egr‐1‐dependent psoriasin expression.

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Cytotoxicity and antiviral activity of electrochemical – synthesized silver nanoparticles against poliovirus

Cited by 123 publications

References 33 publications

Biological Activity of Silver Nanoparticles and Their Applications in Anticancer Therapy

Biological Activity of Silver Nanoparticles and Their Applications in Anticancer Therapy

Review of low-cost point-of-use water treatment systems for developing communities

Silver nanoparticles induce Egr‐1‐dependent psoriasin expression via the ERK and p38 pathways

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