Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (<i>Dendrophthoe pentandra</i>(L.) Miq.) Leaves Extracts

Elsyana, Vida; Bintang, Maria; Priosoeryanto, Bambang Pontjo

doi:10.1155/2016/3242698

Cited by 37 publications

(45 citation statements)

References 20 publications

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“…These findings suggest that the extract of this plant has the important role in inhibiting intestinal inflammation [1]. Extracts of D. pentandra have also been reported to effectively inhibit inflammation, proliferation and induce p53 expression on mice models of colitis-associated colon cancer [28].Analysis of cytotoxicity revealed that the extracts of D. pentandra had cytotoxic effects on K562 and MCM-B2 cell lines thus suggestive of a potential anticancer activity of this plant [29]. Methanolic extracts of D. pentandra leaves have been also found to exert potent anti-proliferative effects on BCR/ABL-Positive and Imatinib Resistant Leukemia Cell lines [30].…”

Section: Discussionmentioning

confidence: 89%

Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

et al. 2018

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Background: Dendrophthoe pentandra (L.) Miq. is a mistletoe species used in traditional medicine. Juice of leaves is used in wound healing, skin infection and cancer; whereas the whole plant is used to treat hypertension and cough. D. pentandra leaf extract has attracted interest due to its pharmacological properties including antioxidant, cytotoxicity and anti-inflammatory effects. In this study, we have investigated the hepatopotective, antihyperglycemic and antidiabetic potential of D. pentandra leaf extracts in rats. Methods: D. pentandra leaf methanolic extract (DPLME) at a fixed dose of 400 mg/kg body weight was evaluated for its effects on fasting glucose levels of rats. DPLME at the same dose was also used to determine the antidiabetic potential in alloxan-induced diabetic rats and the hepatopotective effects on Paracetamol (PCM) intoxicated rats. Results: Oral administration of DPLME exhibited a significantly notable oral glucose tolerance in rats. Single doses of the DPLME displayed very significant antidiabetic activity which was comparable to the activity of the standard antihyperglycemic agent Metformin (MET). DPLME also offered significant hepatoprotection to PCM-intoxicated rats at levels commensurable to the standard hepatoprotective drug Silymarin (SIL).

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Section: Discussionmentioning

confidence: 89%

Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

et al. 2018

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“…Moreover, the highest total phenolic content and iron‐chelating ability among the three different plant parts extracts (leaf, stem, and flower) of S. ferruginea were also found to be in the stem. A number of studies on the other mistletoe genera of Loranthaceae had indicated a strong host‐dependency of many tested bioactivities including anti‐cancer, antiviral, antioxidant, anti‐diabetes, decreasing hypertension, and others …”

Section: Resultsmentioning

confidence: 99%

Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

Xiang

Isa

Fakurazi

et al. 2019

Phytochemical Analysis

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Introduction Scurrula ferruginea (Jack) Danser is a hemi‐parasitic shrub that is widely used as a traditional herbal medicine. Objectives To elucidate the anti‐inflammatory activity of S. ferruginea parasitising on three different hosts of Vitex negundo L., Micromelum minutum (G. Forst.) Wight & Arn. and Tecoma stans (L.) Juss ex HBK., as well as, to determine the metabolite differences related to their anti‐inflammatory properties. Materials and Methods Two plant parts of S. ferruginea, stems and leaves, were extracted in water. The freeze‐dried stem of S. ferruginea grown on T. stans was liquid–liquid partitioned into several solvents. Their potential anti‐inflammatory activity was assessed via inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS) and interferon‐γ (IFN‐γ)‐induced RAW 264.7 macrophage cells. The metabolite variation was examined using proton nuclear magnetic resonance (1H‐NMR) combined with multivariate data analysis (MVDA). Results Scurrula ferruginea stems parasitising on T. stans and V. negundo which were freeze dried exhibited higher anti‐inflammatory activity with IC50 values of 114.47 ± 2.96 and 118.87 ± 2.31 μg/mL, respectively. The mid‐polar ethyl acetate fraction of S. ferruginea hosted on T. stans displayed the highest NO inhibition with 84.80 ± 0.45% at 200 μg/mL. Principal component analysis (PCA) indicated notable and clear discriminations among the different plant parts and host plants based on the identified metabolites. Furthermore, partial least squares (PLS) regression model suggested the anti‐inflammatory bioactivity might be associated with the presence of choline, isoleucine, catechin, leucine and chlorogenic acid. Conclusion This study suggests S. ferruginea could serve as a potential anti‐inflammatory agent, highlighting the importance of T. stans as the host plant.

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“…Indeed, the use of this extract may have/exert negative/adverse effect during painful crisis in sickle cell anemia, similar to caffeine (Wang et al 2009). In contrast, the effect of this plant on membrane of blood cells may be employed to increase the efficacy of antitumor therapy, accordingly to previous report (Elsyana et al 2016, Saghir et al 2016, Tabrizi et al 2016. The potentiation in NPSH and in the hemolysis in erythrocytes treated with plant extracts and t-BHP deserves, doubtless, further research to investigate the involved mechanism(s).…”

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confidence: 80%

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

Bianchini

Galvão

Tamborena

et al. 2017

An. Acad. Bras. Ciênc.

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Mentha pulegium (Lamiaceae) tea has been used as a traditional medicine; however, the modulatory effect of M. pulegium extracts on damage to human erythrocytes associated to t-butyl hydroperoxide (t-BHP) exposure remains to be investigated. Accordingly, we perform this study in order to test the hypothesis that aqueous and ethanolic extracts of M. pulegium could modulate the hemolysis associated to t-BHP exposure, non-protein thiol (NPSH) oxidation and lipid peroxidation (measured as thiobarbituric acid reactive substances -TBARS) in human erythrocytes. Samples were co-incubated with t-BHP (4 mmol/L) and/or aqueous or ethanolic extracts (10-1000 mg/mL) during 120 min to further analysis. We found that both extracts, when associated to t-BHP, potentiate NPSH oxidation and hemolysis. Moreover, both extracts significantly prevents against t-BHP-induced TBARS production. A significant correlation among hemolysis and NPSH levels was found. Taking together, our data points that the association of M. pulegium extracts with t-BHP culminates in toxic effect to exposed erythrocytes, besides its protective effect against t-BHP-induced TBARS production. So, we infer that the use of this extract may exert negative effect during painful crisis in sickle cell anemia. However, more studies are still necessary to better investigate/ understand the mechanism(s) involved in the toxic effect resultant from this association.

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Cytotoxicity and Antiproliferative Activity Assay of Clove Mistletoe (Dendrophthoe pentandra(L.) Miq.) Leaves Extracts

Cited by 37 publications

References 20 publications

Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Hepatoprotective, antihyperglycemic and antidiabetic effects of Dendrophthoe pentandra leaf extract in rats

Phytochemical and anti‐inflammatory properties of Scurrula ferruginea (Jack) Danser parasitising on three different host plants elucidated by NMR‐based metabolomics

Mentha pulegium crude extracts induce thiol oxidation and potentiate hemolysis when associated to t-butyl hydroperoxide in human’s erythrocytes

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