Cytotoxicity and Antimicrobial Activity of the Methanol Extract and Compounds from Polygonum limbatum

Dzoyem, Jean Paul; Nkuete, Antoine H.L.; Kuete, Victor; Tala, Michel Feussi; Wabo, Hippolyte K.; Guru, Santosh Kumar; Rajput, Vikrant Singh; Sharma, Akash; Tane, Pierre; Khan, Inshad Ali; Saxena, Anil Kumar; Laatsch, Hartmut; Tan, Ning‐Hua

doi:10.1055/s-0031-1298431

Cited by 73 publications

(42 citation statements)

References 21 publications

(29 reference statements)

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“…But the combination treatment has significant risk of neutropenia, anemia, and thrombocytopenia side effects, also result in drug resistance. Clinical drug resistance to platinum-based chemotherapy is considered a major impediment in the treatment of cervical cancer (Dzoyem et al, 2012). Its current treatments have a number of undesired adverse side effects.…”

Section: Introductionmentioning

confidence: 99%

In vitro anticancer activity of acetylshikonin action against cervical cancer

Sun¹,

Xu²,

Zhang³

et al. 2014

Plant Sci Today

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Cervical cancer is a malignant neoplasm and is the second commonest cancer in women worldwide. Despite the availability of various treatment modalities, the 5-year survival remains poor. Therefore, it is absolutely necessary to explore drugs capable of preventing and treating cervical cancer. Plant-derived natural products are widely used as adjunct to chemotherapy for this type of cancer. Our study aims to investigate the effects of acetylshikonin, an acetyl derivative, isolated from a Chinese medicinal herb Lithospermum erythrorhizon Sieb. et Zucc., a folk medicine with a long history of safe use for clinically treating cervical cancer in China. MTT assay was used to determine the in vitro anticancer effects of acetylshikonin on human cervical cancer Siha cells. The expression of caspase-3 and -8 proteins were determined. Flow cytometry and quantitative RT-PCR were performed to detect the expression level of Siha cells associated markers and regulatory genes. In Siha cell lines, acetylshikonin inhibited cell growth in a dose-dependent manner. The preferential expression of Siha cells related marker, regulatory genes were also highlighted. It arrested the cell cycle by blocking transition from S phase to G2/M phase and induced apoptosis of Siha cell through activating caspase-3 and caspase-8. In the current study, acetylshikonin can be taken as a promising natural lead for cervical cancer.

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Section: Introductionmentioning

confidence: 99%

In vitro anticancer activity of acetylshikonin action against cervical cancer

Sun¹,

Xu²,

Zhang³

et al. 2014

Plant Sci Today

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“…Several phytochemicals isolated from the Cameroonian medicinal plants were previously reported for their cytotoxicty against cancer cells. Some of them include flavonoids from Polygonum limbatum [9], Dorstenia species [10] and isoflavonoids from Erythrina excelsa and Erythrina senegalensis [8]. Also, the bioactivity of some of the compounds reported herein such as abyssinone IV [11], atalantoflavone [12], bidwillon A [13] and neocyclomorusin [14] was reported.…”

Section: Introductionmentioning

confidence: 91%

Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells

et al. 2014

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“…The range of available flavanones includes (±)-pinostrobin (1), isolated from balsam poplar Populus balsamifera L. 1 The compound 1 has been shown to possess antiproliferative, 2 antimicrobial, 3 neuroprotective, 4 and anti-inflammatory 5 proper-ties. The development of methods for chemical modification of pinostrobin (1) opens new possibilities for creating new compounds with specific biological activity.…”

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confidence: 99%

The flavanone pinostrobin in the synthesis of coumarin-chalcone hybrids with a triazole linker

Lipeeva

Жанымханова²,

Шульц

et al. 2015

Chem Heterocycl Comp

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Flavonoids, including flavones, flavanones, flavanols, and isoflavones, are an important type of plant polyphenols. The range of available flavanones includes (±)-pinostrobin (1), isolated from balsam poplar Populus balsamifera L. 1 The compound 1 has been shown to possess antiproliferative, 2 antimicrobial, 3 neuroprotective, 4 and anti-inflammatory 5 proper-ties. The development of methods for chemical modification of pinostrobin (1) opens new possibilities for creating new compounds with specific biological activity. Our attention was drawn to the possibility to obtain functionalized chalcones from pinostrobin (1) and to perform subsequent transforma-tions in order to build hybrid structures, in particular com-pounds that would combine both chalcone and coumarin fragments.Modified chalcones are of interest for the creation of new drugs against various types of oncological and viral diseases, as well as diabetes. 6 Coumarin-chalcone hybrids have been previously characterized with regard to antimicrobial, 7 antitumor, 8 and anti-inflammatory 9 activity. Structure-activity studies have provided data about the effect of substituents in the chalcone and coumarin fragments on the selectivity of cytotoxic activity with regard to human tumor cells. 8 The analysis of a library of coumarin derivatives, conjugated with 1,2,3-triazole ring at positions 3, 10 4, or 7 11,12 of the coumarin system, showed that triazole ring is an important structural feature for the creation of selective antitumor agents -inducers of tumor cell apoptosis and specific inhibitors of the G2 phase in cell division. Besides that, 1,2,3-triazoles were characterized as potential inhibitors of PDE4В phosphodiesterase, which reduced the proliferation of lung cancer cells and inhibited their angiogenesis. 13 For these reasons, we were interested in the synthesis and study of coumarin-chalcone hybrids containing a 1,2,3-triazole linker. Our objective was to develop a method for the preparation of 2-(bromoalkoxy)-and related 2-(azidoalkoxy)chalcones from pinostrobin (1) and to investigate the possibilities for using these new azides in the synthesis of coumarin-chalcone hybrids.The reaction of pinostrobin (1) with dihaloalkanes (1,4-dibromobutane (2), 1,5-dibromopentane (3), or 1,6-dibromoThe reaction of flavanone pinostrobin with dibromoalkanes in acetone in the presence of potassium carbonate followed the path of retroMichael addition -О-alkylation and resulted in the formation of the respective 2-(bromoalkoxy)chalcones. Treatment of the latter with sodium azide gave the respective azides, which were highly active in the Сu-catalyzed 1,3-dipolar cycloaddition reaction. The reaction of these azides with 6-substituted 7-ethynylcoumarins gave coumarin-chalcone hybrids containing a 1,2,3-triazole linker.

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Cytotoxicity and Antimicrobial Activity of the Methanol Extract and Compounds from Polygonum limbatum

Cited by 73 publications

References 21 publications

In vitro anticancer activity of acetylshikonin action against cervical cancer

In vitro anticancer activity of acetylshikonin action against cervical cancer

Cytotoxic flavonoids and isoflavonoids from Erythrina sigmoidea towards multi-factorial drug resistant cancer cells

The flavanone pinostrobin in the synthesis of coumarin-chalcone hybrids with a triazole linker

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