Cytotoxic withanolides from the aerial parts of Tubocapsicum anomalum

Wang, Sibei; Zhu, Di; Nie, Baisheng; Li, Jing; Zhang, Yingjun; Kong, Ling–Yi; Luo, Jian‐Guang

doi:10.1016/j.bioorg.2018.08.034

Cited by 18 publications

(15 citation statements)

References 35 publications

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“…Therefore, agents that can inhibit STAT3 signal can be used in the treatment and prevention of cancer. TA is identified as a withanolide exhibiting cytotoxicity against a variety of human tumor cell lines [19] . However, the molecular mechanism and inhibitory effect of TA on JAK/STAT3 signaling remain largely unknown.…”

Section: Discussionmentioning

confidence: 99%

“…However, the specific mechanism underlying the suppressive effects of these agents on STAT3 remains largely unexplored. TA, a withanolide isolated from Tubocapsicum anomalum , has been shown to possess potent anti-proliferative activity in several cancer cell lines [18] , [19] . However, its in vitro and in vitro effects on osteosarcoma remain largely unknown.…”

Section: Introductionmentioning

confidence: 99%

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Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Zhu

Chen

Liu

et al. 2021

Journal of Advanced Research

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Zhu

Chen

Liu

et al. 2021

Journal of Advanced Research

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“…Ten new withanolides were isolated from Tubocapsicum anomalum and were screened for anti-proliferative activities against four human tumor cell lines (HCT-116, HepG2, MCF-7, and A375) using cisplatin as a positive control [ 101 ]. Compounds 95 – 99 ( Figure 12 ) were the most potent among all the tested withanolides against all the tested cell lines, with IC 50 values ranging between 0.24–8.71 μM.…”

Section: Withanolides As Anti-cancer Agentsmentioning

confidence: 99%

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

et al. 2022

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Natural products are a major source of biologically active compounds that make promising lead molecules for developing efficacious drug-like molecules. Natural withanolides are found in many flora and fauna, including plants, algae, and corals, that traditionally have shown multiple health benefits and are known for their anti-cancer, anti-inflammatory, anti-bacterial, anti-leishmaniasis, and many other medicinal properties. Structures of these withanolides possess a few reactive sites that can be exploited to design and synthesize more potent and safe analogs. In this review, we discuss the literature evidence related to the medicinal implications, particularly anticancer properties of natural withanolides and their synthetic analogs, and provide perspectives on the translational potential of these promising compounds.

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“…Tubocapsicum anomalum Makino 1908 (Solanaceae) is a medicinal herb with small yellow flowers and red juicy berries (Arcy et al 2001). It is distributed in East Asia and Southeast Asia (Wang et al 2018). Previous studies have indicated that Tubocapsicum anomalum may be developed as a novel class of chemopreventive drugs for the treatment of human cancers (Chang et al 2007;Khan et al 2012).…”

mentioning

confidence: 99%

“…It is distributed in East Asia and Southeast Asia (Wang et al. 2018 ). Previous studies have indicated that Tubocapsicum anomalum may be developed as a novel class of chemopreventive drugs for the treatment of human cancers (Chang et al.…”

mentioning

confidence: 99%

The complete chloroplast genome sequence of wild Japanese pepper Tubocapsicum anomalum Makino (Solanaceae)

Wang

Chen

et al. 2021

Mitochondrial DNA Part B

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As an important medicinal herb, no complete organelle molecular data has been reported for Tubocapsicum anomalum. In this study, the first complete chloroplast genome of Tubocapsicum anomalum Makino was sequenced and assembled. The genome is 155,802 bp in length and contained 124 encoded genes in total, including 75 protein-coding genes, 10 ribosomal RNA genes, and 39 transfer RNA genes. The phylogenomic analysis showed that Tubocapsicum anomalum was closely related to Withania somnifera according the current sampling extent.

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Cytotoxic withanolides from the aerial parts of Tubocapsicum anomalum

Cited by 18 publications

References 35 publications

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Osteosarcoma cell proliferation suppression via SHP-2-mediated inactivation of the JAK/STAT3 pathway by tubocapsenolide A

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

The complete chloroplast genome sequence of wild Japanese pepper Tubocapsicum anomalum Makino (Solanaceae)

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