Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens

Al-Zikri, Putri Nur Hidayah; Taher, Muhammad; Susanti, Deny; Rezali, Mohamad Fazlin; Read, Roger W.; Sohrab, Md. Hossain; Hasan, Choudhury M.; Ahmad, Farediah

doi:10.1016/j.bjp.2014.10.003

Cited by 14 publications

(10 citation statements)

References 18 publications

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“…The known phytosterols, named β-sitosterol (2) and stigmasterol (3) were isolated as a white solid from dichloromethane and ethyl acetate extracts. They were classified as biologically important phytosterols, demonstrating the great structural similarity to those of recently reported cholesterol terpenes [9]…”

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confidence: 59%

“…They were classified as biologically important phytosterols, demonstrating the great structural similarity to those of recently reported cholesterol terpenes. [9]. Also, p-hydroxybenzoic acid (4) was isolated from the methanolic extract of L. scandens.…”

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confidence: 99%

“…Two cytotoxic tirucallane triterpenes were recently isolated from the stem extract of Luvunga scandens (Roxb. ), which effectively inhibited the growth of human breast adenocarcinoma cell line (MCF-7) with IC 50 value in µM region [9]. To this research, we focused on the isolation, structure elucidation and cytotoxicity evaluations of isolated active components from L. scandens against human breast adenocarcinoma cell line (MCF-7), human colon adenocarcinoma cell line (HT29), HeLa cell line and human embryonic kidney (HEK293), including the antioxidant activity.…”

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confidence: 99%

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Phytochemical Constituents from the Root of Luvunga Scandens and Biological Activity Evaluation

Sirinut

Petchkongkeaw

Romsaiyud

et al. 2017

Natural Product Communications

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Isobutylglucosinolate (1) was isolated from the root of Luvunga scandens (Roxb.) for the first time, which demonstrated an antioxidant activity with an IC 50 value of 30.1±0.2 g/mL. Additionally, two biological active phytosterols, named β-sitosterol (2) and stigmasterol (3) were also isolated from Luvunga scandens (Roxb.), showing the low cytotoxicity against human colon adenocarcinoma cell line (HT29) with IC 50 values of 124±1 µg/mL and 141±3 µg/mL, respectively. The chemical structure of all isolated compounds (1-4) was identified by spectroscopic analyses.

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confidence: 59%

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confidence: 99%

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confidence: 99%

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Phytochemical Constituents from the Root of Luvunga Scandens and Biological Activity Evaluation

Sirinut

Petchkongkeaw

Romsaiyud

et al. 2017

Natural Product Communications

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“…The compound was identified as 3α-hydroxy-tirucall-7,24-dien-21-oic acid (as shown in Figure 1A). The chemical structure was identified on the basis of a reference (HidayahAl-Zikri et al, 2014).…”

Section: Resultsmentioning

confidence: 99%

Integrating Strategies of Herbal Metabolomics, Network Pharmacology, and Experiment Validation to Investigate Frankincense Processing Effects

et al. 2018

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In-depth research on processing can promote the globalization of processed herbs. The purpose of this study is to propose an improved strategy for processing effect investigation. Frankincense and processed frankincense were used as research subjects. First, high-speed countercurrent chromatography (HSCCC) and preparation high-performance liquid chromatography (PHPLC) techniques were used for major compounds isolation and minor compounds concentration. Processed frankincense was subjected to two stepwise solvent systems, namely, n-hexane:ethanol:water (6:5:1) and n-hexane:methyl-acetate:acetonitrile:water (4:4:3:4), to yield 12 fractions, and 18 compounds were further separated. Second, a comprehensive metabolomic analysis conducted by ultrahigh-performance liquid-chromatography/electrospray-ionization mass spectrometry (UHPLC-Qtof-MS) coupled with multivariate statistics was performed to fully characterize the chemical components and discover the potential biomarkers between frankincense and processed frankincense. In total, 81 metabolites, including the 18 separated compounds, were selected as potential biomarkers between frankincense and processed frankincense among 153 detected compounds for their VIP values of greater than one. The tirucallane-type compounds and components with 9,11-dehydro structures clearly occurred at high levels in the processed frankincense, while lupine-type compounds and those with 11-keto structures were significantly higher in frankincense. Then, a network pharmacology model was constructed to decipher the potential mechanisms of processing. Intestinal absorption properties prediction indicated the possibility of processing-related absorption enhancement. A systematic analysis of the constructed networks showed that the C-T network was constructed with 18 potential biomarkers and 69 targets. TNF and IL-1β were among the top-ranked and were linked by 8 and 7 pathways, which were mainly involved in inflammation. The arachidonic acid metabolism pathway exhibited the highest number of target connections. Finally, the prediction was validated experimentally by an intestinal permeability and efficacy assay. The experiments provided convincing evidence that processed frankincense harbored stronger inhibition effects toward TNF-α-, IL-1β- and arachidonic acid-induced platelet aggregation. The processing procedure leads to changes of the chemical metabolites, which triggers the enhancement of absorption and cure efficiency. The global change of the metabolites, absorption and pharmacological effects of processing were depicted in a systematic manner.

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“…The AuNPs indicated the highest antitumor activity with the IC50 value of 65.47±3.09 µM against MCF-7, moderate activity with NCI H460, and Hep G2 at different concentrations. The antitumor activity of the AuNPs was also compared with it of the extracted constituents from the Root of Luvunga Scandens in a previous article [23]. The AuNPs were exposed to higher activity than compounds, which extracted from Root of Luvunga Scandens against MCF-7 and Hep G2.…”

Section: Energy Dispersive X-ray (Edx) Spectrummentioning

confidence: 99%

Gold Nanoparticles from Ostruthin: Green Synthesis, a Stable Mechanism, Antitumor, and Antibacterial Activity

Minh¹,

Van²,

Minh³

et al. 2020

Rev. Chim.

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The Ostruthin was extracted and identified its structure from rhizomes of Luvunga scandens located at Ta Cu Mountain, Binh Thuan province, Vietnam for the first time. Gold nanoparticles (AuNPs) were synthesized by the green method. The AuNPs acted as antitumor against breast cancer cell line (MCF-7), human liver cancer cell line (HepG2), and Non-Small Cell Lung (NCI-H460). They showed the potential antitumor activity against MCF-7 with the IC50 value of 65.47�3.09 �M. The antitumor activity of the AuNPs was also compared with the extracted constituents from the root of Luvunga Scandens in a previous article. The AuNPs were exposed to high antitumor activity against MCF-7 and Hep G2, human cancer cell lines. The AuNPs have also been tested the antibacterial activity and shown the moderate antibacterial activity on both Salmonella enterica and Bacillus subtilis at a concentration of 0.25 mM.

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Cytotoxic tirucallane triterpenes from the stem of Luvunga scandens

Cited by 14 publications

References 18 publications

Phytochemical Constituents from the Root of Luvunga Scandens and Biological Activity Evaluation

Phytochemical Constituents from the Root of Luvunga Scandens and Biological Activity Evaluation

Integrating Strategies of Herbal Metabolomics, Network Pharmacology, and Experiment Validation to Investigate Frankincense Processing Effects

Gold Nanoparticles from Ostruthin: Green Synthesis, a Stable Mechanism, Antitumor, and Antibacterial Activity

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