Cytotoxic Terpene Quinones from Marine Sponges

Abstract

The 1,4-benzoquinone moiety is a common structural feature in a large number of compounds that have received considerable attention owing to their broad spectrum of biological activities. The cytotoxic and antiproliferative properties of many natural sesquiterpene quinones and hydroquinones from sponges of the order Dictyoceratida, such as avarol, avarone, illimaquinone, nakijiquinone and bolinaquinone, offer promising opportunities for the development of new antitumor agents. The present review summarizes the structure and cytotoxicity of natural terpenequinones/hydroquinones and their bioactive analogues and derivatives.

Antibacterial Meroterpenoids from the South China Sea Sponge <i>Dysidea</i> sp.

“…3) These compounds have attracted much interest due to their structural diversity and varied biological activities, including anti-human immunodeficiency virus (HIV), 4) antibacterial, 5) antifungal, 6) antioxidative, 7) antitumor, 8) anti-inflammatory, 9) inhibition against protein tyrosine kinase (PTK) and protein tyrosine phosphatase 1B (PTP1B), 10,11) and activation of hypoxia-inducible factor-1 (HIF-1) activities. 12) During our search for bioactive metabolites from tropical sponges, we encountered a purple-colored encrusting Dysidea sp.…”

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Key words meroterpenoid; marine sponge; antibacterial activity; DysideaMarine organisms such as sponges represent a largely unexploited source of a wide variety of natural meroterpenoids.1) Sponges of the genus Dysidea are a rich source of bioactive meroterpenoids, the majority of which are sesquiterpene quinones/quinols.2) This class of compounds frequently consist of sesquiterpene moieties linked to quinones, quinols, or structural analogues.3) The sesquiterpene unit is of biosynthetic interest, as it usually features a drimane-or a 4,9-friedodrimane-type skeleton comprising a trans-or a less common cis-fused ring junction.3) These compounds have attracted much interest due to their structural diversity and varied biological activities, including anti-human immunodeficiency virus (HIV), 4) antibacterial, 5) antifungal, 6) antioxidative, 7) antitumor, 8) anti-inflammatory, 9) inhibition against protein tyrosine kinase (PTK) and protein tyrosine phosphatase 1B (PTP1B), 10,11) and activation of hypoxia-inducible factor-1 (HIF-1) activities.

12)During our search for bioactive metabolites from tropical sponges, we encountered a purple-colored encrusting Dysidea sp. off the south China sea.

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Maristem—Stem Cells of Marine/Aquatic Invertebrates: From Basic Research to Innovative Applications

“…However, industries traditionally lack familiarity with the marine environment. The latter, with its vast genetic richness, is a potential source of new products of socio-economic value, as marine organisms produce molecules (enzymes, biopolymers, bioactive compounds, and secondary metabolites) with applications in various fields, such as nutraceutics, cosmetics, antibiotics, disease-fighting drugs, antifouling products, biomaterials, and more [21][22][23][24][25]. In addition, marine invertebrates exhibit a kaleidoscope of MISC types that participate in the production of this plethora of novel bioactive molecules (antitumor, antimicrobial, and anti-inflammatory), with significant potential interest for human health and wellbeing.…”

Cultivation of Marine Sponges with Pharmaceutical Value: Status and Future Prospects in India

“…They are anti-tumour (Tasdemir et al, 2002;Gordaliza, 2010) have potent antileukemic activity (Muller et al, 1985), inhibitory activity against hepatocellular carcinoma, colorectal carcinoma and breast adenocarcinoma cells (Elhady et al, 2016). They are used for the treatment of psoriasis (Pietschmann et al, 2004), as anti foulant (Pereira et al, 2002;Riberio et al, 2012), in cosmetics (Swatschek et al, 2002), for marine environmental bioremediation in integrated aquaculture practices (Milanese et al, 2003), bioremediation in polluted sea water (Stabili et al, 2006), to clear large volume of water of organic and bacterial loads in polluted sites (Ledda et al, 2014) as their pumping activity might play an important role in water purification.…”