Cytotoxic T-lymphocyte antigen 4 gene polymorphism influences the incidence of symptomatic human cytomegalovirus infection after renal transplantation

Abstract

These results suggested that CTLA4 variants might be involved in the clinical manifestation of HCMV diseases.

Association of functional genetic variants of CTLA4 with reduced serum CTLA4 protein levels and increased risk of idiopathic recurrent miscarriages

“…The expression of alternatively spliced flCTLA4 and sCTLA4 isoforms are influenced by the CTLA4 5 0 -upstream regulatory region and 3 0 -untranslated region gene polymorphisms (37,40,41). We have reported four noncoding region SNPs in the 5 0 -upstream regulatory region at positions À318, À658, À1147, and À1661, one SNP þ49 A>G (rs231775) in exon 1, and in the 3 0 -untranslated region noncoding region consisting of one SNP þ6230 A>G (rs3087243) (21). The noncoding region variants of CTLA4 gene may result in abnormal alternative splicing.…”

“…The detection of genetic variants of the CTLA4 polymorphic markers rs231775, rs5742909, rs11571317, rs16840252, rs4553808, and rs3087243 were performed by polymerase chain reaction (PCR) followed by restriction fragment length polymorphism (RFLP) analysis using primer sequences and restriction enzymes as reported elsewhere (21). To validate the results from PCR-RFLP and for quality control, almost 15% of the samples were randomly selected for regenotyping along with DNA sequencing, and the results were checked for concordance.…”

“…The most often reported polymorphic markers of CTLA4 are present either in the upstream regions (rs5742909, rs11571317, rs16840252, and rs4553808 in the promoter region and rs231775 in exon 1) or in downstream regions (rs3087243) (19)(20)(21)(22). Few studies have evaluated rs231775 tag-SNP in IRM (23,24), and CTLA4 tag-SNPs other than rs231775 have not been fully explored in IRM.…”

LILRB1 polymorphisms influence posttransplant HCMV susceptibility and ligand interactions

“…The significance of the association of LILRB1 SNPs with HCMV disease is that it may be useful as part of a collection of biomarkers used to determine the relative risk for patients after receiving a transplant and to guide prophylactic use of antivirals in these patients. Many studies have investigated genetic influences on the immune response to HCMV; the genes implicated in modulating the control of HCMV after transplantation include IL-28B, CCL8, several microRNA, CLTA4, TLR9, DC-SIGN, and, most relevant to NK cells, NKG2C and KIRs (40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56). Further studies with additional cohorts could be useful to pinpoint the SNPs with the best correlation and to explore the relationship to the sequence of UL18 within each patient.…”

Genetic variation in Micro-RNA genes of host genome affects clinical manifestation of symptomatic Human Cytomegalovirus infection

“…Recently, It has been reported that the genetic variants of host genome may affect clinical manifestation of symptomatic HCMV infections after renal transplantation [11]. In the present study, we hypothesized that the variations in Host Micro-RNA genes may be associated with clinical manifestation of symptomatic HCMV infection by modulating miRNA expression, maturation or miRNA-mRNA interaction.…”