Cytotoxic T cells and mycobacteria

Silva, C

doi:10.1016/s0378-1097(01)00099-4

Cited by 4 publications

(4 citation statements)

References 43 publications

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“…These effects could be due to cytokines present in the pulmonary parenchyma, as high levels of IFN-γ were detected in mice immunized with both naked hsp65 and COMP-hsp65 (Figure 7 ). This finding suggests that COMP-hsp65 is a promising vaccine, since a Th1 immune response could be important for the development of protective immunity against M. tuberculosis infection [ 29 , 40 - 42 ]. On the other hand, production of the regulatory cytokine IL-10 was reduced in vaccines that conferred effective protection against M. tuberculosis infection (naked hsp65 and COMP-hsp65), when compared to non-immunized mice.…”

Section: Discussionmentioning

confidence: 99%

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

et al. 2008

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Background: The greatest challenges in vaccine development include optimization of DNA vaccines for use in humans, creation of effective single-dose vaccines, development of delivery systems that do not involve live viruses, and the identification of effective new adjuvants. Herein, we describe a novel, simple technique for efficiently vaccinating mice against tuberculosis (TB). Our technique consists of a single-dose, genetic vaccine formulation of DNA-hsp65 complexed with cationic liposomes and administered intranasally.

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Section: Discussionmentioning

confidence: 99%

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

et al. 2008

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“…The importance of NO 2 − , IL-12, and IFN-␥ has been well documented in murine tuberculosis. [32][33][34] IFN-␥ is a central factor in the activation of antimycobacterial activities of macrophages and is considered crucial for protection against tuberculosis. 35 Nitric oxide is an effective hostdefense mechanism against many microbial pathogens and plays an essential role in the killing of M. tuberculosis by mononuclear phagocytes.…”

Section: Discussionmentioning

confidence: 99%

The Immune Response to Toxocariasis Does Not Modify Susceptibility to Mycobacterium tuberculosis Infection in BALB/c Mice

et al. 2007

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Mycobacterium tuberculosis and helminth infections coincide geographically and are classically described as TH1 and TH2 pathologies. There is much interest in exploring how concurrent worm infections might alter immune responses to mycobacterial infection. To explore this issue, mice were infected with Toxocara canis and co-infected with M. tuberculosis. Mice infected with M. tuberculosis had high numbers of neutrophils and mononuclear cells within the alveolar spaces, with increased parenchymal interferon (IFN)-gamma levels. However, in Toxocara-infected mice we detected increased eosinophil numbers in bronchoalveolar lavage fluid (BALF) and increased parenchymal levels of interleukin (IL)-5. In co-infected mice the BALF demonstrated enhanced eosinophil influx with decreased neutrophil and mononuclear cell accumulation. However, co-infected mice had similar mycobacterial proliferation in their lungs accompanied by similar histopathological changes and similar cytokine/nitric oxide production compared with Mycobacterium-only-infected mice. Our results suggest that T. canis infection does not necessarily lead to increased susceptibility to pulmonary tuberculosis.

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“…These cytokines have multiple important effects including the activation of macrophages to produce nitric oxide and the stimulation of phagosome–lysosome fusion (10). In addition, CD4 + T cells activate macrophages and dendritic cells through surface‐bound molecules such as CD40 ligand and also mediate cytotoxicity against infected cells through expression of Fas ligand (FasL) and potentially other cytolytic effector molecules (11–13). Major histocompatibility complex (MHC) class I‐restricted CD8 + T cells also carry out many of these functions including the production of IFN‐γ and are believed to make unique contributions to immunity against intracellular bacteria such as M. tuberculosis through their potent cytolytic activity against infected cells.…”

Section: T‐cell Immunity To M Tuberculosismentioning

confidence: 99%

Evasion and subversion of antigen presentation by Mycobacterium tuberculosis

2009

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Mycobacterium tuberculosis is one of the most successful of human pathogens and has acquired the ability to establish latent or progressive infection and persist even in the presence of a fully functioning immune system. The ability of M. tuberculosis to avoid immune-mediated clearance is likely to reflect a highly evolved and coordinated program of immune evasion strategies, including some that interfere with antigen presentation to prevent or alter the quality of T-cell responses. Here, we review an extensive array of published studies supporting the view that antigen presentation pathways are targeted at many points by pathogenic mycobacteria. These studies show the multiple potential mechanisms by which M. tuberculosis may actively inhibit, subvert or otherwise modulate antigen presentation by major histocompatibility complex class I, class II and CD1 molecules. Unraveling the mechanisms by which M. tuberculosis evades or modulates antigen presentation is of critical importance for the development of more effective new vaccines based on live attenuated mycobacterial strains.

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Cytotoxic T cells and mycobacteria

Cited by 4 publications

References 43 publications

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

Protection against tuberculosis by a single intranasal administration of DNA-hsp65 vaccine complexed with cationic liposomes

The Immune Response to Toxocariasis Does Not Modify Susceptibility to Mycobacterium tuberculosis Infection in BALB/c Mice

Evasion and subversion of antigen presentation by Mycobacterium tuberculosis

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