Cytotoxic T cells and mycobacteria

Silva, Célio Lopes; Bonato, Vânia Luiza Deperon; Lima, Karla de Melo; Coelho-Castelo, Arlete Aparecida Martins; Faccioli, Lúcia Helena; Sartori, Alexandrina; Souza, Ana Olı́via de; Leão, Sylvia Cardoso

doi:10.1111/j.1574-6968.2001.tb10575.x

Cited by 25 publications

(9 citation statements)

References 56 publications

(64 reference statements)

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“…These pro-inflammatory cytokines increase the bactericidal activity of macrophages and activate CD8 T lymphocytes [7,8]. …”

Section: Introductionmentioning

confidence: 99%

“…The adaptive resistance to infection caused by facultative intracellular bacteria, such as C. pseudotuberculosis, is related to CD4 T cells and, more specifically, to clones that produce Th1-type cytokines, mainly IFN-γ and TNF-α. These pro-inflammatory cytokines increase the bactericidal activity of macrophages and activate CD8 T lymphocytes [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

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MAPK involvement in cytokine production in response to Corynebacterium pseudotuberculosis infection

et al. 2014

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BackgroundCaseous lymphadenitis (CL) is a contagious infectious disease of small ruminants caused by Corynebacterium pseudotuberculosis. Is characterized by the formation of abscesses in the lymph nodes and intestines of infected animals, induced by inflammatory cytokines. The production of cytokines, such as IL-10, TNF-α, IL-4 and IFN-γ, is regulated by mitogen-activated protein kinase (MAPK) pathway activation. The present study investigated the involvement of MAPK pathways (MAPK p38, ERK 1 and ERK 2) with respect to the production of cytokines induced by antigens secreted by C. pseudotuberculosis over a 60-day course of infection. CBA mice (n = 25) were divided into three groups and infected with 102 colony forming units (CFU) of attenuated strain T1, 102 CFU of virulent strain VD57 or sterile saline solution and euthanized after 30 or 60 days. Murine splenocytes were treated with specific inhibitors (MAPK p38 inhibitor, ERK 1/2 inhibitor or ERK 2 inhibitor) and cultured with secreted antigens obtained from pathogenic bacteria (SeT1 or SeVD57).ResultsThe MAPK pathways evaluated were observed to be involved in the production of IL-10, under stimulation by secreted antigens, while the MAPK p38 and ERK 1 pathways were shown to be primarily involved in TNF-α production. By contrast, no involvement of the MAPK p38 and ERK 1 and 2 pathways was observed in IFN-γ production, while the ERK 2 pathway demonstrated involvement in IL-4 production only in the mouse splenocytes infected with VD57 under stimulation by SeT1.ConclusionThe authors hypothesize that MAPK p38 and ERK 1 pathways with respect to TNF-α production, as well as the MAPK p38 and ERK 1 and 2 pathways in relation to IL-10 production under infection by C. pseudotuberculosis are important regulators of cellular response. Additionally, the lack of the MAPK p38 and ERK 1/2 pathways in IFN-γ production in infected CBA murine cells stimulated with the two secreted/excreted antigens, in IL-4 production showing involvement only via the ERK 2 pathway under stimulation by SeT1 antigen during 60-day infection period with the virulent strain, suggests that these pathways regulated the production of pro-inflammatory and regulatory cytokines in the splenic cells of CBA mice.

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“…These pro-inflammatory cytokines increase the bactericidal activity of macrophages and activate CD8 T lymphocytes [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

MAPK involvement in cytokine production in response to Corynebacterium pseudotuberculosis infection

et al. 2014

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“…T-cell cytokines including IFN-γ and other T helper 1 (Th1) cytokines can activate antimicrobial activities in macrophages. Then, T cells kill M. tuberculosis directly and Mycobacteria-reactive T cells can infect macrophages, which seems to be a prerequisite for killing by T cells of microbes residing inside macrophages [12,18,19].…”

Section: Immune Response To M Tuberculosis Infectionmentioning

confidence: 99%

“…LQVPSPSMGRDIKVQFQ (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) LQVPSPSMGRDIKVQFQSGG (11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30) GRDIKVQFQSGGNNSPA (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)...…”

Section: Sequence In Ag85b Of Mtb Mycobacterium Hostunclassified

Novel Vaccine Candidates against Tuberculosis

Zheng

Terreni

et al. 2020

CMC

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Ranking above AIDS, Tuberculosis (TB) is the ninth leading cause of death affecting and killing many individuals every year. Drugs’ efficacy is limited by a series of problems such as Multi- Drug Resistance (MDR) and Extensively-Drug Resistance (XDR). Meanwhile, the only licensed vaccine BCG (Bacillus Calmette-Guérin) existing for over 90 years is not effective enough. Consequently, it is essential to develop novel vaccines for TB prevention and immunotherapy. This paper provides an overall review of the TB prevalence, immune system response against TB and recent progress of TB vaccine research and development. Several vaccines in clinical trials are described as well as LAM-based candidates.

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“…M. tuberculosis stimulation leads to the macrophage activation and enhanced production of cytokines such as: IL-1, IL-6, IL-12 and TNF-a (Silva et al, 2001). While IL-12 induces type 1 helper T cell (T h 1) responses and IFN-g production by T cells and natural killer (NK) cells (De Jong et al, 1998), IFN-g stimulates human macrophages to produce TNF-a and activates uninfected macrophages to kill intracellular bacteria (Flynn and Ernst, 2000).…”

Section: Introductionmentioning

confidence: 99%

Proinflammatory Cytokine Profile in Active Kidney Tuberculosis Patients

Kozioł-Montewka

Kolodziejek

Oles

et al. 2004

Immunological Investigations

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Our study demonstrates the increase of TNF-alpha and IL-12 level in comparison to control group. TNF-alpha concentration was about 2-fold higher in the positive patients than it was in control group; IL-12 concentration was about 4-fold higher and the differences between IL-12 levels were statistically important (p < 0.05). However, no significant differences were found in IFN-gamma level among all groups. Using Spearman correlation rank test, a significant correlation was found between TNF-alpha and IL-12 in the positive patient group. The correlation factor was more significant for the group of patients with Mycobacterium tuberculosis present in blood and urine than it was in urine positive PCR group (r = -0.66 vs. r = -0.51).

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Cytotoxic T cells and mycobacteria

Cited by 25 publications

References 56 publications

MAPK involvement in cytokine production in response to Corynebacterium pseudotuberculosis infection

MAPK involvement in cytokine production in response to Corynebacterium pseudotuberculosis infection

Novel Vaccine Candidates against Tuberculosis

Proinflammatory Cytokine Profile in Active Kidney Tuberculosis Patients

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