Cytotoxic Sesquiterpenoids from Atractylodes chinensis (DC.) Koidz.

Abstract

Four new sesquiterpenoids named atrchiterpenes A–D (1–4), a new natural product (5), and twelve known compounds (6–17) were isolated from Atractylodes chinensis (DC.) Koidz. Compound 1 was a rare N‐containing eudesmane‐type sesquiterpenoid. Structure elucidation was performed by spectroscopic techniques, including 1D, 2D NMR spectra, and HR‐ESI‐MS. Compounds 6–11, 14, and 17 were reported from Atractylodes for the first time. All the isolated compounds were evaluated for cytotoxicity activity. Compound 16 showed moderate cytotoxicity against HepG2 cells with an IC50 value of 5.81±0.47.

Efficacy and Potential Mechanism of Essential Oils of Three Labiatae Plants against the Pathogenic Fungi of Root Rot Disease in Atractylodes chinensis

“…Atractylodes chinensis is a perennial plant of the genus Atractylodes of the family Asteraceae [42]. In recent years, spurred by the increasing demand for A. chinensis, its artificial cultivation has expanded across many areas.…”

Phytochemistry and Pharmacology of Sesquiterpenoids from Atractylodes DC. Genus Rhizomes

“…Subsequently, twenty undescribed eudesmane-type sesquiterpenes named atramacronoids D-W (21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40) were identified in the rhizomes of A. macrocephala using extensive spectroscopic data analysis, Snatzke's rule, ECD calculations, and X-ray crystallographic analysis [45,46]. A chemical investigation of the ethanol extract of A. lancea resulted in the isolation of nine eudesmanetype sesquiterpenoids (41)(42)(43)(44)(45)(46)(47)(48)(49), and their structures were elucidated using spectroscopic techniques and HRESIMS [47]. Kamauchi et al [48] gained two new eudesmane-type sesquiterpenoids, namely 3α-hydroxy pterocarpol (50) and (11R)-2,11,12-trihydroxy-bselinene (51), along with three known sesquiterpenoids (52)(53)(54) in the fermented rhizomes of A. lancea using column chromatography.…”

“…Liu et al [65] elucidated a secoguaiane lactone glycoside featuring 6/7 cores, named secoatractylohexone A (114), and a 9,10-unsaturated guaiene-type glycoside, named dihydroxy-9-guaine-3-one-11-O-β-D-glucopyranoside (115), along with three known guaiane-type sesquiterpenes (116)(117)(118), from the rhizomes of A. lancea on the basis of extensive spectroscopic data and the application of the CD technique. 4,10,11-trihydroxyguaiane (119), atrchiterpene D (120), and macrochaetoside B (121) were elucidated from A. lancea using NMR spectra and HRESIMS [47]. The EtOAc fraction of the A. macrocephala rhizomes was subjected to silica gel, Sephadex LH-20 column chromatography, and semi-preparative HPLC to obtain atractylmacrol A (122) [54].…”