Cytotoxic Quinones from the Roots of Aloe dawei

Abstract

Seven naphthoquinones and nine anthraquinones were isolated from the roots of Aloe dawei by chromatographic separation. The purified metabolites were identified by NMR and MS analyses. Out of the sixteen quinones, 6-hydroxy-3,5-dimethoxy-2-methyl-1,4-naphthoquinone is a new compound. Two of the isolates, 5,8-dihydroxy-3-methoxy-2-methylnaphthalene-1,4-dione and 1-hydroxy-8-methoxy-3-methylanthraquinone showed high cytotoxic activity (IC 50 1.15 and 4.85 µM) on MCF-7 breast cancer cells, whereas the others showed moderate to low cytotoxic activity against MDA-MB-231 (ER Negative) and MCF-7 (ER Positive) cancer cells.

Soluble epoxide hydrolase inhibitory activity of anthraquinone components from Aloe

“…The conformations of the inhibitors within their predicted binding sites were detected by simulating molecular docking to obtain insight into the interactions between the enzyme and its ligands (1)(2)(3)(4)(5)(6)(7)(8). All the inhibitors were confirmed to prefer allosteric sites over the active site.…”

“…The candidate inhibitory compounds (1)(2)(3)(4)(5)(6)(7)(8) were analyzed in an enzyme kinetic study to assess the binding mode between the receptor and ligands. The enzyme inhibition properties of these derivatives were modeled using double-reciprocal plots (LineweaverBurk and Dixon analyses).…”

“…3 The primary phytochemical constituents of Aloe are chromones, 4 anthraquinones, 5 and pyrones. 6 Some of these constituents have multiple biological properties, such as, anti-tumor, 7 antioxidant, 8 anti-inflammatory, 9 anti-aging, 10 and anti-diabetic properties. 11 The bioactive components of Aloe, called chromones from exhibit potent antioxidative, anti-inflammatory and mushroom tyrosinase inhibitory activities.…”

Cytotoxic Compounds from Aloe megalacantha

“…While the genus Aloe is the most extensively investigated species due to its rich medicinal value and chemotaxonomic aspect, no phytochemical analysis and biological activities of A. megalacantha have been reported. Thus, as part of our ongoing search for new bioactive natural products of plants from the Asphodelaceae family [ 11 , 12 , 13 ], we report the isolation of four new natural products 1 – 4 , along with ten known compounds (one coumarin and nine anthraquinones). The cytotoxicity of the compounds against the human cervix carcinoma cell line KB-3-1 is also reported.…”

In-Silico UHPLC Method Optimization for Aglycones in the Herbal Laxatives Aloe barbadensis Mill., Cassia angustifolia Vahl Pods, Rhamnus frangula L. Bark, Rhamnus purshianus DC. Bark, and Rheum palmatum L. Roots

“…Depending on the plant species, these anthraquinone aglycones are aloe-emodin, rhein, emodin, chrysophanol, and/or physcion ( Figure 1 ). On the one hand, these aglycones exert numerous biological effects and potentially other effects relevant to pharmacology, for example, anticancer, anti-inflammatory, and antifungal effects [ 2 , 3 , 4 , 5 ]. On the other hand, aloe-emodin and emodin show some genotoxic effects in vitro [ 6 , 7 , 8 , 9 ] which were not visible in vivo (aloe-emodin) [ 6 , 10 , 11 ] or herbal extracts [ 12 , 13 , 14 , 15 ].…”