Cytotoxic properties of rhenium(i) tricarbonyl complexes of N-heterocyclic carbene ligands

Abstract

A family of eight rhenium(I) tricarbonyl complexes bearing pyridyl-imidazolylidene or bis-imidazolylidene ligand in combination with a series of N-acetyl amino acids ligands (glycine, isoleucine, proline) and acetate have been synthesised...

A S=3/2 Cr(III) Complex In A Square‐Capping NHC Framework

“…This ligand is most closely related to the dianionic NN 4 topology of the B 2 Pz 4 Py ligand, [1,2] as well as to charge neutral frameworks consisting of five nitrogenous donors like N4Py, [3] ImPy 3 N, [4] PY5Me 2 and their derivatives; [5,6] or the charge neutral P 2 Ph PP 2 Ph and P 2 Me PP 2 Ph frameworks consisting of five phosphine donors [7] . While the coordination chemistries of monodentate, [8–10] bidentate, [11–16] tripodal [17–20] and macrocyclic [21–25] NHC ligands are well developed, study of the coordination chemistry of square‐capping NHC frameworks are in their infancy. NHC ligands are an attractive alternative to widely used phosphine ligands as they share strong σ‐donor and moderate π‐accepting ability, are insensitive to oxidizing conditions, [26] and can support a wide variety of oxidation states best exemplified by isolable complexes of iron ranging from +6 to 0 [13,19,27] …”

“…Ph and P 2 Me PP 2 Ph frameworks consisting of five phosphine donors. [7] While the coordination chemistries of monodentate, [8][9][10] bidentate, [11][12][13][14][15][16] tripodal [17][18][19][20] and macrocyclic [21][22][23][24][25] NHC ligands are well developed, study of the coordination chemistry of square-capping NHC frameworks are in their infancy. NHC ligands are an attractive alternative to widely used phosphine ligands as they share strong σ-donor and moderate π-accepting ability, are insensitive to oxidizing conditions, [26] and can support a wide variety of oxidation states best exemplified by isolable complexes of iron ranging from + 6 to 0.…”

Anticancer Activities of Re(I) Tricarbonyl and Its Imidazole-Based Ligands: Insight from a Theoretical Approach

“… 16 , 17 Upon investigations on vast numbers of rhenium compounds with higher oxidation states, alongside hetero-metallic complexes, researchers have given little attention to Re(I) tricarbonyl complexes. 18 These compounds were observed to possess anticancer characteristics of a chemotherapeutic drug and phytophysical properties. 14 Research has proven that rhenium complexes possess cytotoxic and phototoxic properties against malevolent/malignant cells.…”

“…The potential of rhenium complexes was first identified in tricarbonyl bismine complexes in the HeLa cells . Rhenium is more economically feasible; hence, all center of attention has been conveyed to these significant Re­(I) tricarbonyl complexes applied as a cancer drug in therapeutics. , Upon investigations on vast numbers of rhenium compounds with higher oxidation states, alongside hetero-metallic complexes, researchers have given little attention to Re­(I) tricarbonyl complexes . These compounds were observed to possess anticancer characteristics of a chemotherapeutic drug and phytophysical properties .…”

A Tetrapodal Penta‐Carbene Ligand and Iron(III) Complex

“…Coordination compounds of the B 2 Pz 4 Py ligand have provided complexes of Fe and Co relevant to nitrogen fixation, [25][26][27] vitamin B12, [28] and dioxygen reduction. [29] Considering the rich chemistry of coordination complexes supported by monodentate, [30][31][32] bidentate, [33][34][35][36][37][38] tripodal [39][40][41][42] and macrocyclic [43][44][45][46][47] ligands consisting of N-heterocyclic carbene (NHC) donors a particularly striking absence in the tetrapodal pentadentate family of ligands are those composed of equatorial and axial NHC donor groups. Intrigued by the impact a pentadentate framework composed entirely of NHC donors would have on the chemistry of first-row transition metals we undertook the preparation of the tricationic protoligand [CC 4H5 Me ](OTf) 3 (3).…”