Cytotoxic Potential of N-hexadecanoic Acid Extracted from Kigelia pinnata Leaves

Ravi, Lokesh; Каннабиран, Кришнан

doi:10.3923/ajcb.2017.20.27

Cited by 97 publications

(51 citation statements)

References 10 publications

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“…The ethyl cyclodocosane has been reported to possess antitumor and antiproliferative activity against HeLa cell line (Alkhatib et al, 2019). n-hexadecanoic acid that we found in the GC-MS analysis has also been earlier proved to show anticancer activity in HCT-116 cells (Ravi and Krishnan, 2017). 2,6,10,15-tetramethyl heptadecane was found to be involved in the metabolism of ovarian cancer stem cells (Vermeersch et al, 2014).…”

Section: Discussionsupporting

confidence: 59%

Crude Cell-Free Extract From Deinococcus radiodurans Exhibit Anticancer Activity by Inducing Apoptosis in Triple-Negative Breast Cancer Cells

Maqbool

Sudharsan

Kanimozhi³

et al. 2020

Front. Cell Dev. Biol.

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Extremophilic organisms have the potential to tolerate extremely challenging environments of nature. This property can be accredited to its production of novel secondary metabolites that possess anticancer and other pharmaceutical values. The present study was aimed to investigate the anticancer activity of crude secondary metabolite extract (CSME) obtained from the radiation-tolerant bacterium Deinococcus radiodurans in triple-negative human breast carcinoma (MDA-MB-231) cells. The 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay showed the antiproliferative potential of CSME in MDA-MB-231 cells (IC 50 = 25 μg/ml) and MCF-7 cells (IC 50 = 10 μg/ml). Further, the CSME treatment led to the production of intracellular reactive oxygen species (ROS) and nuclear membrane alterations with the formation of apoptotic bodies in MDA-MB-231 cells. Considerable DNA damage and low antioxidant status were observed in CSME-treated MDA-MB-231 cells. The results also showed that the CSME treatment induced apoptotic markers expression in MDA-MB-231 cells. Western blot results illustrated significant upregulation of p53, caspase-3, and caspase-9 proteins expression. Then, we analyzed the presence of secondary metabolites which may be linked with antiproliferative potential of CSME by gas chromatography-mass spectrometry (GC-MS). The results illustrated the presence of 23 bioactive compounds some of which are already reported to possess anticancer properties. The study indicates that the CSME of D. radiodurans possess anticancer properties and exhibit the potential to be used as an anticancer agent.

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Section: Discussionsupporting

confidence: 59%

Crude Cell-Free Extract From Deinococcus radiodurans Exhibit Anticancer Activity by Inducing Apoptosis in Triple-Negative Breast Cancer Cells

Maqbool

Sudharsan

Kanimozhi³

et al. 2020

Front. Cell Dev. Biol.

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“…A critical observation was the presence of a major peak of an unknown compound. Octadecanoid acid and hexadecenoic acid exhibit antiproliferative activity, antioxidant activity, and anti-microbial activities (Habib et al, 1987;Ravi and Krishnan, 2017;Ashraf et al, 2018). In our study, the presence of above-mentioned fatty acids in A. unguis mycelium could be greatly contributing to its antioxidant activity.…”

Section: Discussionmentioning

confidence: 55%

Antiproliferative Role of Secondary Metabolites From Aspergillus unguis AG 1.1 (G) Isolated From Marine Macroalgae Enteromorpha sp. by Inducing Intracellular ROS Production and Mitochondrial Membrane Potential Loss Leading to Apoptosis

2020

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Drug resistance to the classically used chemotherapeutic drugs is the major challenge in their treatment of cancer needing the discovery of novel anticancer drugs. In terms of finding novel therapeutics, endophytes are quite promising as they are an excellent source of novel structures, which exhibit bioactivity. The present study demonstrated a dose-dependent antiproliferative activity of mycelial-derived secondary metabolites from a macroalgae associated endophyte Aspergillus unguis AG 1.1 (G). The antiproliferative activity of A. unguis mycelial extract (AUME) was observed on different human cancer cell lines. PI live/dead assay further confirmed the cytotoxic potential of the mycelial extract. Furthermore, AUME caused mitochondrial membrane aberration and generated ROS production as well indicating its potential to induce cell death by apoptosis. The metabolic profiling of the mycelial extract using GC-MS and LC-MS/MS revealed the presence of fatty acids, a benzoquinolinone derivative, imidazolidinedione derivative, diethyl phthalate and phthalate acid ester, a difuraxanthone, two prenylxanthone analogs and a phthalide derivative and some unknown metabolites. Presence of 4-(4-Hydroxy-3,5-dimethoxy-phenyl)-3,4-dihydro-1H-benzo[h]quinolin-2-one, 1-hydroxy-3,5-dimethoxy-2-prenylxanthone, 1,6-dihydroxy-3-methoxy-2-prenylxanthone and 3butylidene-7-hydroxyphthalide in AUME could be correlated to the notable cytotoxicity exhibited by the endophyte. The additional presence of many unidentified compounds heightened the prospects of finding some novel bioactive metabolites. Our results indicated that secondary metabolites produced by A. unguis AG 1.1 (G) have therapeutic potential as anticancer agents.

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“…For example, phytol contains antioxidant, anti-inflammatory, and antinociceptive activities [ 121 , 129 ]. Hexadecanoic acid is famous for its anti-inflammatory [ 130 ] and cytotoxicity potentials [ 131 ], whereas β-bisabolene possesses a strong cancer cytotoxicity effect [ 132 ] and has a balsamic odor that led to its approval as a food additive. Heptacosane has been used as a nutritional supplement and sweetener to mend aftertaste [ 133 ].…”

Section: Functional Ingredients In Food Applicationsmentioning

confidence: 99%

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

Chen

Razali

Saikim

et al. 2021

Foods

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Morus alba L. (M. alba) is a highly adaptable plant that is extensively incorporated in many traditional and Ayurveda medications. Various parts of the plant, such as leaves, fruits, and seeds, possess nutritional and medicinal value. M. alba has abundant phytochemicals, including phenolic acids, flavonoids, flavonols, anthocyanins, macronutrients, vitamins, minerals, and volatile aromatic compounds, indicating its excellent pharmacological abilities. M. alba also contains high nutraceutical values for protein, carbohydrates, fiber, organic acids, vitamins, and minerals, as well as a low lipid value. However, despite its excellent biological properties and nutritional value, M. alba has not been fully considered as a potential functional food ingredient. Therefore, this review reports on the nutrients and bioactive compounds available in M. alba leaves, fruit, and seeds; its nutraceutical properties, functional properties as an ingredient in foodstuffs, and a microencapsulation technique to enhance polyphenol stability. Finally, as scaling up to a bigger production plant is needed to accommodate industrial demand, the study and limitation on an M. alba upscaling process is reviewed.

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Cytotoxic Potential of N-hexadecanoic Acid Extracted from Kigelia pinnata Leaves

Cited by 97 publications

References 10 publications

Crude Cell-Free Extract From Deinococcus radiodurans Exhibit Anticancer Activity by Inducing Apoptosis in Triple-Negative Breast Cancer Cells

Crude Cell-Free Extract From Deinococcus radiodurans Exhibit Anticancer Activity by Inducing Apoptosis in Triple-Negative Breast Cancer Cells

Antiproliferative Role of Secondary Metabolites From Aspergillus unguis AG 1.1 (G) Isolated From Marine Macroalgae Enteromorpha sp. by Inducing Intracellular ROS Production and Mitochondrial Membrane Potential Loss Leading to Apoptosis

Morus alba L. Plant: Bioactive Compounds and Potential as a Functional Food Ingredient

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