Cytotoxic Phenylpropanoids and an Additional Thapsigargin Analogue Isolated from Thapsia garganica.

Abstract

Cytotoxic Phenylpropanoids and an Additional Thapsigargin Analogue Isolated from Thapsia garganica. -Four new phenylpropanoids (I) and a new thapsigargin analogue (II) are isolated from the fruits of the title plant. The former are found to be potent cytotoxins. -(LIU, H.; JENSEN, K. G.; TRAN, L. M.; CHEN, M.; ZHAI, L.; OLSEN, C. E.; SOEHOEL, H.; DENMEADE, S. R.; ISAACS, J. T.; CHRISTENSEN*, S. B.; Phytochemistry 67 (2006) 24, 2651-2658; Dep. Med. Chem., Dan. Univ. Pharm. Sci., DK-2100 Copenhagen, Den.; Eng.) -H. Haber 15-207