Cytotoxic phenylpropanoid glycosides from <i>Cirsium japonicum</i>

Shang, Dong-Li; Ma, Qinge; Wei, Rongrui

doi:10.1080/10286020.2016.1194831

Cited by 10 publications

(2 citation statements)

References 18 publications

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“…In addition, the mechanism of the hepatoprotective effect was studied regarding their potential antioxidant and anti-inflammatory properties. Moreover, previous phytochemical studies have revealed that flavonoids, lignans, phenylpropanoids, triterpenes, volatile oils, and steroids exist in CH, especially flavonoids [ 11 , 12 , 22 , 23 , 24 , 25 ]. Therefore, we also compared the phytoconstituents of four Cirsium species by spectrophotometric assay and high-performance liquid chromatography–photodiode array detector (HPLC-DAD).…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

Zhao

Chang

Lin

et al. 2018

IJMS

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Species of Cirsium (Asteraceae family) have been used in folk hepatoprotective medicine in Taiwan. We collected four Cirsium species—including the aerial part of Cirsium arisanense (CAH), the aerial part of Cirsium kawakamii (CKH), the flower part of Cirsium japonicum DC. var. australe (CJF), and Cirsii Herba (CH)—and then made extractions from them with 70% methanol. We compared the antioxidant contents and activities of these four Cirsium species extracts by a spectrophotometric method and high-performance liquid chromatography–photodiode array detector (HPLC-DAD). We further evaluated the hepatoprotective effects of these extracts on CCl4-induced acute liver damage in C57BL/6 mice. The present study found CAH possesses the highest antioxidant activity among the four Cirsium species, and these antioxidant activities are closely related to phenylpropanoid glycoside (PPG) contents. The extracts decreased serum ALT and AST levels elevated by injection with 0.2% CCl4. However, only CJF and CH decreased hepatic necrosis. Silibinin decreased serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels and hepatic necrosis caused by CCl4. CJF and CH restored the activities of hepatic antioxidant enzymes and decreased hepatic malondialdehyde (MDA) levels. CJF further restored the expression of hepatic antioxidant enzymes including Cu/Zn-superoxide dismutase (Cu/Zn-SOD), Mn-superoxide dismutase (Mn-SOD), and glutathione S-transferase (GST) proteins. HPLC chromatogram indicated that CKH, CJF, and CH contained silibinin diastereomers (α and β). Only CJF contained diosmetin. Hence, the hepatoprotective mechanism of CJF against CCl4-induced acute liver damage might be involved in restoring the activities and protein expression of the hepatic antioxidant defense system and inhibiting hepatic inflammation, and these hepatoprotective effects are related to the contents of silibinin diastereomers and diosmetin.

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Section: Introductionmentioning

confidence: 99%

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

Zhao

Chang

Lin

et al. 2018

IJMS

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“…The filtrates were concentrated under reduced pressure until elimination of EtOH to obtain a black crude extract (0.95 kg), which was suspended in H 2 O and partitioned successively with Antiangiogenic chromanones from Cynanchum thesiodes Natural Product Communications Vol. 13 (12) 2018 1657 petroleum ether, EtOAc, and n-butanol, successively [14,15]. As a result, petroleum ether soluble fraction (88.6 g), EtOAc soluble fraction (217.3 g), and n-butanol soluble fraction (294.3 g) were obtained from the above extract, respectively.…”

Section: Extraction and Isolationmentioning

confidence: 95%

Antiangiogenic Chromanones from Cynanchum thesiodes

Wei

Zhong

et al. 2018

Natural Product Communications

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A total of 10 chromanone derivatives (1-10), including two new compounds (1 and 2), were isolated from the fruits of Cynanchum thesiodes, and their structures were identified based on UV, IR, MS and NMR spectroscopic data, and comparison with those of reference compounds. The isolated compounds (1-10) were evaluated for their antiangiogenic activity by MTT assay using axitinib as a positive control. As a result, 1, 2, 3 and 9 exhibited important antiangiogenic activity with IC 50 values of 13.

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Six Natural Phenylethanoid Glycosides: Total Synthesis, Antioxidant and Tyrosinase Inhibitory Activities

et al. 2020

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Total synthesis of six natural phenylethanoid glycosides (PhEGs) has been accomplished. Key steps in the divergent synthesis strategy involved glycosylation based on trichloroacetimidate donors, and one‐pot removal of benzyl and 4,6‐O‐benzylidene acetal groups by hydrogenation over Pd/C. Among them, four natural PhEGs, scroside D (2), rebouoside B (3), ginkgoside C (4), and ginkgoside D (5) were synthesized for the first time. In the subsequent antioxidant and tyrosinase inhibitory activities evaluation, all compounds showed strong DPPH radical scavenging activities, and compounds 1–2, 5–6 exhibited obvious inhibitory activities against mushroom tyrosinase.

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Cytotoxic phenylpropanoid glycosides from Cirsium japonicum

Cited by 10 publications

References 18 publications

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

Comparison of the Hepatoprotective Effects of Four Endemic Cirsium Species Extracts from Taiwan on CCl4-Induced Acute Liver Damage in C57BL/6 Mice

Antiangiogenic Chromanones from Cynanchum thesiodes

Six Natural Phenylethanoid Glycosides: Total Synthesis, Antioxidant and Tyrosinase Inhibitory Activities

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