Cytotoxic Performance of Synthesized Mn‐Doped ZnO Nanorods in MCF‐7 Cells

Abstract

This report presents the outcomes of exerting extracted Salvadora persica for synthesizing ZnO nanoparticles (ZnO−NP) and Mn‐doped ZnO nanorods (Mn−ZnO−NRs) through a viable and economical “green” route. The products characteristics were configured by the means of X‐ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy‐dispersive X‐ray (EDX) spectroscopy, UV‐visible spectroscopy (UV‐Vis) and Raman assessing technics. As the constructional evaluations approved the progress of well crystalline nano, the EDX analyses approved the doping of Mn, which interestingly succeeded in significantly altering the spherical framework of ZnO into a rod‐looking structure. The following steps involved the employment of MTT trial to assay the cytotoxic impacts of our sample towards breast (MCF‐7: Michigan Cancer Foundation‐7) cancer cell line, resulting in confirming the superior outcomes of Mn−ZnO−NRs than the solitary case of ZnO. The boosted functionality of the doped product may be attributable to the appearance of Mn into the lattice of ZnO. In addition, the evolved morphology of ZnO, obtained through the doping process, could have caused substantial developments in the cytotoxic operation of doped sample as well.

Study of Cytotoxic and Antibacterial Activity of Ag‐ and Mg‐Dual‐Doped ZnO Nanoparticles

“…The perceived peaks for ZnO and AgÀ Mg/ZnO NP were indexed to (100), ( 002), ( 101), ( 102), ( 110), ( 103), ( 200), (112), and ( 201) and seemed to correspond to the hexagonal form of ZnO (JCPDS-36-1451). [37] Taking the data of Figure 1 in account, although the implication of silver in doped nanoparticles caused the appearance of Ag peaks at the PXRD pattern, yet the absence of detecting any other extra peaks signified the purity and supreme crystalline shape of synthesized product. We configured the crystalline size of our particles by the Debye-Scherer formula in equation (D = Kλ/β cosθ; where D refers to the crystallite size of nanoparticles, K would be the shape factor, λ represents the wavelength of exerted radiation, β stands for the full width at half maxima (FWHM) in radians, and θ is the angle of diffraction).…”

“…We configured the crystalline size of our particles by the Debye-Scherer formula in equation (D = Kλ/β cosθ; where D refers to the crystallite size of nanoparticles, K would be the shape factor, λ represents the wavelength of exerted radiation, β stands for the full width at half maxima (FWHM) in radians, and θ is the angle of diffraction). The full width at half maxima (FWHM) of XRD peak (101) was applied to Debye-Scherrer formula [37] for estimating the average crystallite size of 25.37 and 27.87 nm for ZnO and AgÀ Mg/ZnO NP, respectively. In according to Figure 1,…”

“…[35] Zinc oxide is one of the five known zinc compounds that have been widely used in medicine and nanotechnology. [36,37] Plant extracts as a plant reducer can be used to produce green, easy and nontoxic of nanoparticles. [38] Prosopis fracta belongs to the Leguminosea family, which is native to arid and semi-arid regions of Asia, Africa and America.…”