Cytotoxic pathways activated by multifunctional thiosemicarbazones targeting sigma-2 receptors in breast and lung carcinoma cells
Joanna Kopecka,
Alessandra Barbanente,
Daniele Vitone
et al.
Abstract:Background
Multifunctional thiosemicarbazones (TSCs) able to bind sigma receptors and chelate metals are considered as a promising avenue for the treatment of pancreatic cancer due to the encouraging results obtained on in vitro and in vivo models. Here, we assessed the biochemical mechanism of these TSCs also on lung (A549) and breast (MCF7) cancer cells.
Methods
The density of sigma-2 receptors in normal (BEAS-2B and MCF10A) and in lung and breast (A549 … Show more
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