Cytotoxic nor-dammarane triterpenes from Viburnum hainanense Merr. et Chun

Wang, Wei; Song, Juan; Shi, Guobing; Yu, Qinggong

doi:10.1016/j.fitote.2016.02.006

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…et Chun, and compounds 57 , 60 , 63 and 64 showed cytotoxic potential against seven human tumor cell lines (Hep‐2, SCL‐1, CAL‐27, UMSCC‐1, Detroit‐562, SCC‐PKU, and TCA‐83). Among them, the ones with an acetyl moiety at C‐12 exhibited more significant cytotoxic activity, including 60 , displaying the highest cytotoxic activities against all tested tumor cell lines (IC 50 values in the range of 5.2–7.4 μM) and 63 , showing stronger cytotoxicity than 64 [25] . From Viburnum mongolicum , six new nor‐dammarane triterpenoids ( 58 , 61 , 62 , 76 , 84 and 85 ) and one known compound 75 were identified.…”

Section: Chemical Constituents and Biological Activitiesmentioning

confidence: 99%

Recent Advance on Chemistry and Bioactivities of Secondary Metabolites from Viburnum Plants: An Update

Chen

Zhao

Zhang

et al. 2021

Chemistry & Biodiversity

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Viburnum species are a group of small trees or shrubs that are of great ornamental and medicinal values. Some of them have been used for a long time both as conventional and ethnic medicine. Viburnum fruits, eaten in fresh and processed forms, have been revealed to contain various health‐promoting nutrients. With the increasing research on Viburnum plants, they are considered to be an abundant resource of bioactive natural products possessing diverse pharmacological properties and unique chemical structures, that is powerfully proved by the existence of structurally novel vibsane‐type diterpenoids which only occur in Viburnum species, newly discovered lignan constituents with unusual side chains and other noteworthy natural components. This review describes 185 new and 228 known secondary metabolites from Viburnum genus between 2008 and 2020, including their chemical structures, sources and bioactivities, and highlights the corresponding structure‐activity relationships.

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Section: Chemical Constituents and Biological Activitiesmentioning

confidence: 99%